Category: 52718-95-3

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52718-95-3, name is Methyl 2-bromonicotinate, molecular formula is C7H6BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Methyl 2-bromonicotinate

1,3-Benzene-diboronic acid (0.66 g, 3.99 mmol), compound 6 (1.80 g, 8.37 mmol), K2CO3 (1.10 g, 7.97 mmol) and Pd(dppf)Cl2 (0.146 g, 0.2 mmol) were dissolved in a degassed mixture of THF/water (20 mL/4 mL). The mixture was heated to 70C and stirred overnight under N2. After cooling to room temperature, saturated solution of chloride ammonium (100 mL) was added, and aqueous layer was extracted with dichloromethane (3×50 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether:ethyl acetate=5:1; V/V) to give the compound 7 as a colorless oil (1.03 g, 74%).

With the rapid development of chemical substances, we look forward to future research findings about 52718-95-3.

Reference:
Article; Tan, Shuai; Wu, Xiugang; Zheng, Yanqiong; Wang, Yafei; Chinese Chemical Letters; vol. 30; 11; (2019); p. 1951 – 1954;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 52718-95-3, Adding some certain compound to certain chemical reactions, such as: 52718-95-3, name is Methyl 2-bromonicotinate,molecular formula is C7H6BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52718-95-3.

Intermediate [1-B] (1.5 eq), methyl-2-bromoicotinate (1.1 eq), CuI (0.03 g), K2CO3 (2.0 eq), and L-Proline (0.04 eq) were dissolved in toluene (0.1 M) and stirred at a temperature of 130 i for 12 hours. After the reaction mixture was cooled to room temperature, and an organic layer was dried by using magnesium sulfate and concentrate, and column chromatography was used to obtain Intermediate [1-C] (yield: 59%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52718-95-3, Methyl 2-bromonicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Samsung Display Co., Ltd.; KANG, Sunwoo; JEON, Sangho; CHO, Youngmi; (80 pag.)US2020/168817; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52718-95-3, name is Methyl 2-bromonicotinate. A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 2-bromonicotinate

Step 1) Methyl 2-[(4-Hydroxymethyl)phenyl]-3-pyridinecarboxylate To a stirred solution of methyl 2-bromo-3-pyridinecarboxylate (3.45 g, 14.39 mmol) and 4-(trimethylstannyl)benzyl alcohol (3.90 g, 14.39 mmol), prepared as described in Step 1 of Example 3, in DMF (25 mL) was added bis(acetonitrile)palladium dichloride (0.19 g, 0.72 mmol) and CuI (0.27 g, 1.44 mmol). After 18 h, bis(triphenylphosphine)palladium dichloride (0.20 g, 0.28 mmol) and CuI (0.11 g, 0.57 mmol) were added and stirring was continued for 2 days at room temperature. The mixture was concentrated, taken up in water, and extracted with EtOAc. The combined extracts were washed with brine, dried, and concentrated. Purification by flash chromatography (50% EtOAc/hexane) gave 277 mg (8%) of product as a yellow oil. 1 H NMR (CDCl3) delta 3.69 (s, 3H), 4.69 (s, 2H), 7.35 (m, 1H), 7.38 (d, J=8.2 Hz, 2H), 7.49 (d, J=8.2 Hz, 2H), 8.08 (dd, J=7.9, 1.8 Hz, 1H), 8.75 (m, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52718-95-3, Methyl 2-bromonicotinate.

Reference:
Patent; American Home Products Corporation; US5283242; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 52718-95-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52718-95-3, name is Methyl 2-bromonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Part D. Preparation of methyl 2-(3′-cyanophenyl)nicotinate. Methyl 2-bromonicotinate (2.0 g, 9.3 mmol) and 3-cyanophenylboronic acid (2.7 g, 18.4 mmol) were combined in 190 mL benzene. Sodium carbonate (19 mL of a 2 M aqueous solution), tetrabutylammonium bromide (152 mg, 0.5 mmol), and bis(triphenylphosphine)palladium(II) chloride (325 mg, 0.5 mmol) were added. The entire mixture was evacuated to remove dissolved gasses, then placed under argon. The reaction was refluxed for 14 hours, diluted with water and EtOAc, separated, dried over Na2 SO4, filtered, and evaporated. The resulting yellow solid was chromatographed on silica gel (30% EtOAc/hexanes) to yield a light yellow solid (1.70 g, 77%). 1 H NMR (CDCl3): delta 8.81 (dd, 1H, J=4.8, J’=1.8), 8.23 (dd, 1H, J=8.0, J’=1.9), 7.85 (s, 1H), 7.73 (m, 2H), 7.55 (t, 1H, J=7.7), 7.43 (m, 1H), 3.76 (s, 3H).

According to the analysis of related databases, 52718-95-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dupont Pharmaceuticals; US6060491; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem