Category: 53052-06-5

Synthetic Route of 53052-06-5 ,Some common heterocyclic compound, 53052-06-5, molecular formula is C6H4N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-(Mbetathv)thio)ri,31oxazolor4,5-biPyridine; A 250 mL RB flask, equipped with a magnetic stirring bar and nitrogen gas inlet, was charged with [1,3]oxazolo[4,5-b]pyridine-2(3H)-thione (5.00 g, 32.9 mmol), potassium carbonate (4.54 g, 32.8 mmol), and 80 mL of anhydrous DMF. Then iodomethane (2.45 mL, 5.57 g, 39.3 mmol) was added dropwise to the stirring reaction mixture under nitrogen. The mixture was stirring for 2 h, then diluted with 300 mL of water, and extracted with EtOAc (4×150 mL). The combined organic extract was washed with water (3×100 mL), then with brine (100 mL), dried over Na2SO4 and evaporated to give 4.53 g (83 %) of 2- (methylthio)[1,3]oxazolo[4,5-b]pyridine as a tan solid. LCMS m/z (M+H): 167.1. 1H NMR (300 MHz, DMSO-d6): delta 8.44 (1H), 8.08 (1H), 7.35 (1H), 2.81 (3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 53052-06-5, Oxazolo[4,5-b]pyridine-2(3H)-thione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER INC.; WO2006/51410; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 53052-06-5, name is Oxazolo[4,5-b]pyridine-2(3H)-thione. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H4N2OS

Example 1 Production of 6-(oxazolo[4,5-b]pyridin-2-ylthio)-N-(2,6-diisopropylphenyl)hexanamide Potassium carbonate (64 mg, 0.47 mmol) and 18-crown-6 (11 mg, 0.04 mmol) were added to a solution of 2-mercaptooxazolo[4,5-b]pyridine (64 mg, 0.42 mmol) and 6-bromo-N-(2,6-diisopropylphenyl)hexanamide (150 mg, 0.42 mmol) in DMF (3 ml), and the resulting mixture was stirred at 80 C. for4 hours. After there action solution was diluted with water, the organic layer was extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate, from which the solvents were distilled off. The residue was purified by silica gel column chromatography (elution solvents: hexane:ethyl acetate=2:1); the resulting crystal was recrystallized from ethyl acetate-hexane, to recover the objective compound of 49 mg (at a yield of 27%) as a colorless needle-like crystal. Melting Point: 94-95 C. IR (KBr) cm-1: 3230, 2965, 1646, 1497, 1403. 1H-NMR (d6-DMSO) delta: 1.14 (12H, d, J=6.8 Hz), 1.52-1.68 (2H, m), 1.68-1.82 (2H, m), 1.82-1.97 (2H, m), 2.33-2.45 (2H, m), 3.11 (2H, sept, J=6.8 Hz), 3.43 (2H, t, J=7.0 Hz), 7.12 (1H, d, J=8.1 Hz), 7.12 (1H, d, J=6.6 Hz), 7.22 (1H, dd, J=8.1, 6.6 Hz), 7.31 (1H, dd, J=8.1, 4.8 Hz), 7.98 (1H, dd, J=8.1, 1.5 Hz), 8.42 (1H, d, J=4.8 Hz), 8.72 (1H, br s). EIMS m/z (relative intensity): 425 (M+), 407 (100). Elementary Analysis: C24H31N3O2S Required: C, 67.73; H, 7.34; N, 9.87; S, 7.53. Found: C, 67.68; H, 7.33; N, 9.86; S, 7.57.

With the rapid development of chemical substances, we look forward to future research findings about 53052-06-5.

Reference:
Patent; Kowa Company, Ltd.; US6362208; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem