Category: 5315-25-3

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Electric Literature of 5315-25-3.

Fujiwara, Yusuke;Takayama, Tomoaki;Nakazawa, Jun;Okamura, Masaya;Hikichi, Shiro research published 《 Development of a novel scorpionate ligand with 6-methylpyridine and comparison of the structural and electronic properties of nickel(II) complexes with related tris(azolyl)borates》, the research content is summarized as follows. A novel anionic tridentate borate ligand with a 6-methylpyridyl donor, Tpy^Me, has been synthesized. Comparison of the mol. structures and reactivities of nickel(II)-bromido complexes with tris(azolyl)borate ligands composed of pyridyl, pyrazolyl, or oxazolinyl donors indicates the characteristic sterically demanding nature and strong electron donating ability of Tpy^Me.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Electric Literature of 5315-25-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Computed Properties of 5315-25-3.

Giordano, Marco;Volpi, Giorgio;Bonomo, Matteo;Mariani, Paolo;Garino, Claudio;Viscardi, Guido research published 《 Methoxy-substituted copper complexes as possible redox mediators in dye-sensitized solar cells》, the research content is summarized as follows. Three aromatic diimine ligands and the corresponding homoleptic copper(I) and copper(II) complexes have been synthesized and characterized. The copper(II) derivatives are stabilized by an ancillary chlorido ligand. The nature of the chelating ligand seriously impacts the photophys. and electrochem. properties of the complexes. The substitution of the pendant Me groups with methoxy influences the coordination geometry of the complexes, resulting in an intramol. dynamic equilibrium between different coordination modes (i.e. nitrogen and oxygen binding), proved by variable-temperature ¹H-NMR measurements. As a proof of concept, the most promising complexes were employed as redox mediators in semi-transparent dye-sensitized solar cells. Once implemented in devices, the nature of the ligand plays a crucial role: the methoxy-substituted derivatives appear upon severe ligand exchange with tert-butylpyridine, resulting in an unexpectedly high open circuit voltage.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Computed Properties of 5315-25-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Computed Properties of 5315-25-3.

Dash, Dibyajit;Baral, Minati;Kanungo, B. K. research published 《 Synthesis of a new tetradentate chelator with 1-Hydoroxy-2(1H)-pyridinone (HOPO) as chelating unit: Interaction with Fe(III), solution thermodynamics and DFT studies》, the research content is summarized as follows. 1,2-Hydroxypyridinone (1,2-HOPO) forms very stable transition metal complexes that may be useful in various ways, among these the iron complexes have been long used for the treatment of iron overload diseases like β-Thalassemia. A new tetradentate chelator, 1-hydroxy-N-[3-[2-[2-[3-[(1-hydroxy-6-oxo-pyridine-2-carbonyl)amino]propoxy]ethoxy]ethoxy]propyl]-6-oxo-pyridine-2-carboxamide (L) having two 1,2-HOPO units with long chain amine backbone has been synthesized and characterized through various techniques like TLC, solubility, m.p., FT-IR, ¹H NMR, ¹³C NMR, ESI-MS, UV-Vis and emission spectroscopy. The protonation constants of the ligand were determined by both potentiometrically as well as spectrophotometrically in aqueous medium at 25° ±1°C. The solution thermodn. of the ligand its Fe(III) complexes in aqueous solution were also studied. The pK_a values for ligand are found to be 7.34 and 6.06 and the formation constant of metal complex (M₂L₃) is found to be logβ₂₃₀ = 42.45. To support the exptl. data, theor. calculation at DFT level of theory was done using GGA (Gradient Generalized Approximation) with BLYP functional and DZP basis set. The results of calculated thermodn. properties suggest that, ΔG follows the same trend of protonation as determined by potentiometry and spectrophotometry. Studies of the DFT optimized structures of LH₂, LH^– shows that, there is π stacking interaction between the hydroxypyridinone rings in the species and the intramol. π-stacking interaction decreases as the distance between two pyridine ring increases upon deprotonation and was found to be 2.7, 3.2 and 14.6 Å for LH₂, LH^– and L^-2 resp.

Computed Properties of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Category: pyridine-derivatives.

Dong, Jie;Yuan, Xiang-Ai;Yan, Zhongfei;Mu, Liying;Ma, Junyang;Zhu, Chengjian;Xie, Jin research published 《 Manganese-catalysed divergent silylation of alkenes》, the research content is summarized as follows. Transition-metal-catalyzed, redox-neutral dehydrosilylation of alkenes is a long-standing challenge in organic synthesis, with current methods suffering from low selectivity and narrow scope. The authors report a general and simple method for the Mn-catalyzed dehydrosilylation and hydrosilylation of alkenes, with Mn₂(CO)₁₀ as a catalyst precursor, by using a ligand-tuned metalloradical reactivity strategy. This enables versatility and controllable selectivity with a 1:1 ratio of alkenes and silanes, and the synthetic robustness and practicality of this method are demonstrated using complex alkenes and light olefins. The selectivity of the reaction was studied using d. functional theory calculations, showing the use of an ⁱPrPNP ligand to favor dehydrosilylation, while a JackiePhos ligand favors hydrosilylation. The reaction is redox-neutral and atom-economical, exhibits a broad substrate scope and excellent functional group tolerance, and is suitable for various synthetic applications on a gram scale. [graphic not available: see fulltext].

Category: pyridine-derivatives, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. SDS of cas: 5315-25-3.

Duan, Jindian;Choy, Pui Ying;Gan, Kin Boon;Kwong, Fuk Yee research published 《 N-Difluoromethylation of N-pyridyl-substituted anilines with ethyl bromodifluoroacetate》, the research content is summarized as follows. A general protocol for N-difluoromethylation of aniline derivatives was developed. Com. available Et bromodifluoroacetate served as a difluorocarbene source in the presence of a base. This carbene surrogate was attractive owing to its favorable stability, environmental friendliness and inexpensiveness. This reaction system featured notable operational simplicity (bench top-grade solvents can be used without any pre-drying and do not require inert atm. protection). A wide range of functional groups in aniline derivatives were well-tolerated and good-to-excellent product yields were generally obtained.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., SDS of cas: 5315-25-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Application In Synthesis of 5315-25-3.

Duan, Zhe;Liu, Jingqiu;Niu, Liping;Wang, Jun;Feng, Mingqian;Chen, Hua;Luo, Cheng research published 《 Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening》, the research content is summarized as follows. IDH1 mutations are early events in the development of IDH-mutant gliomas and leukemias and are associated with various regulation of mol. process. Mutations of active site in IDH1 could lead to high levels of 2-HG and the suppression of cellular differentiation, while these changes can be reversed by mol. inhibitors target mutant IDH1. Here, through inhouse developed enzymic assay-based high throughput screening platform, we discovered DC_H31 as a novel IDH1-R132H/C inhibitor, with the IC₅₀ value of 0.41 μmol/L and 2.7 μmol/L resp. In addition, saturable SPR binding assay indicated that DC_H31 bound to IDH1-R132H/C due to specific interaction. Further computational docking studies and structure-activity relationship (SAR) suggest that DC_H31 could occupy the allosteric pocket between the two monomers of IDH1-R132H homodimer, which accounts for its inhibitory ability. And it is possible to conclude that DC_H31 acts via an allosteric mechanism of inhibition. At the cellular level, DC_H31 could inhibit cell proliferation, promote cell differentiation and reduce the production of 2-HG with a dose-dependent manner in HT1080 cells. Taken together, DC_H31 is a potent selective inhibitor of IDH1-R132H/C both in vitro and in vivo, which can promote the development of more potent pan-inhibitors against IDH1-R132H/C through further structural decoration and provide a new insight for the pharmacol. treatment of gliomas.

Application In Synthesis of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Quality Control of 5315-25-3.

Chen, Mingwei;Hu, Jinyu;Tang, Xiaoli;Zhu, Qiming research published 《 Piperazine as an Inexpensive and Efficient Ligand for Pd-Catalyzed Homocoupling Reactions to Synthesize Bipyridines and Their Analogues》, the research content is summarized as follows. In the present work, a promising approach for preparation of bipyridines and their (hetero) aromatic analogs I (Ar = 2-pyridyl, 4-O₂NC₆H₄, quinolin-2-yl, etc.) via a Pd-catalyzed reductive homocoupling reaction with simple piperazine as a ligand is discussed . The combination of Pd(OAc)₂ and piperazine in DMF was observed to form an excellent catalyst system and efficiently catalyzed the homocoupling of azaarenyl halides, in which DMF was used as the solvent without excess reductants although stoichiometric reductant was generally required to generate the low-oxidation-state active metal species in the catalytic cycles. In this case, good to excellent yields of bipyridines were obtained in the presence of 2.5 mol% of Pd(OAc)2 and 5 mol% of piperazine, using K₃PO₄ as a base in DMF at 140°C. The coupling reaction was operationally simple and displayed good substrate compatibility.

Quality Control of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Formula: C6H6BrN.

Chen, Ying;Xu, Lanting;Jiang, Yongwen;Ma, Dawei research published 《 Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides》, the research content is summarized as follows. α-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and Et cyanoacetate under mild conditions, affording α-(hetero)arylacetonitriles via one-pot decarboxylation. Addnl., the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with α-alkyl-substituted Et cyanoacetates proceeds smoothly at 60°C, leading to the formation of α-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls. Thus, e.g., 4-chloroanisole + Et cyanoacetate → 2-(4-methoxyphenyl)acetonitrile (up to 80%).

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Application of C6H6BrN.

Chen, Yuegang;Wang, Xin;He, Xu;An, Qing;Zuo, Zhiwei research published 《 Photocatalytic Dehydroxymethylative Arylation by Synergistic Cerium and Nickel Catalysis》, the research content is summarized as follows. Under mild reaction conditions with inexpensive cerium and nickel catalysts, easily accessible free alcs. can now be utilized as operationally simple and robust carbon pronucleophiles in selective C(sp³)-C(sp²) cross-couplings. Facilitated by automated high-throughput experimentation, sterically encumbered benzoate ligands have been identified for robust cerium complexes, enabling the synergistic cooperation of cerium catalysis in the emerging metallaphotoredox catalysis. A broad range of free alcs. and aromatic halides can be facilely employed in this transformation, representing a new paradigm for the C(sp³)-C(sp²) bond construction between free alcs. and aryl halides with the extrusion of formaldehyde. Moreover, mechanistic investigations have been conducted, leading to the identification of a tribenzoate cerium(III) complex as a viable intermediate.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Application of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Category: pyridine-derivatives.

Chen, Zhixiang;Jiang, Yongwen;Zhang, Li;Guo, Yinlong;Ma, Dawei research published 《 Oxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction》, the research content is summarized as follows. A robust and practical protocol for preparing alkyl aryl ethers has been developed, which relies on using two types of ligands to promote Cu-catalyzed alkoxylation of (hetero)aryl halides. The reaction scope is very general for a variety of coupling partners, particularly for challenging secondary alcs. and (hetero)aryl chlorides. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to alkoxylation of aryl iodides complete at room temperature Addnl., a number of carbohydrate derivatives are applicable for this coupling reaction, affording the corresponding carbohydrate-aryl ethers in 29-98% yields.

Category: pyridine-derivatives, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem