Category: 5337-79-1

Electric Literature of 5337-79-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5337-79-1, name is 3-(Pyridin-4-yl)acrylic acid, molecular formula is C8H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 33; (alphaR,gammaS,2S)-N-((3S,4S)-3,4-dihydro-3-hydroxy-2H-1-benzopyran-4-yl)-gamma-hydroxy4-[(5-phenyl-2-furanyl)methyl]-alpha-(4-pyridinylmethyl)-2-[[(2,2,2-trifluoroethyl)amino]carbonyl]-1-piperazinepentanamide; To a solution of 3-(4-pyridyl)-acrylic acid (25.0 g, 168 mmol) in 1:1 ethanol:THF (250 mL) was added 10% Pd(0)/C (2.50 g). The reaction vessel was placed under 110 psi of H2 until 1.0 equivalent of H2 had been consumed as indicated by a pressure drop in the reaction vessel. The mixture was then diluted with 1 L of hot methanol and filtered through celite, rinsing with hot methanol. The liquid obtained was concentrated in vacuo, affording 11.0 g (43% of 3-(4-pyridyl)-propionic acid. This material was dissolved in DMF (300 mL), and to this solution was added the aminochromanol intermediate from Example 1, Step L (12.0 g, 72.5 mmol), HOBT (11.7 g, 87.0 mmol), di-iso-propylethylamine (27.8 mL, 159 mmol) and HBTU (27.5 g, 72.5 mmol). After 2 hours at ambient temperature, the reaction was quenched with 0.5 N aqueous NaHCO3 (500 mL) and diluted with ethyl acetate (1 L). The organic layer was washed with 0.5 N NaHCO3 (300 mL×3), brine (300 mL), dried (MgSO4), and concentrated in vacuo, affording 13.2 g (61%) of the amide as a white solid. A portion of this material (2.27 g, 7.61 mmol) was dissolved in dichloromethane (100 mL), and 2-methoxypropene (3.64 mL, 38 mmol) was added, followed by camphorsulfonic acid (1.20 g, 5.17 mmol). After 3 hours at ambient temperature the reaction was quenched by the addition of 1.4 mL of triethylamine, and concentrated in vacuo. Purification by flash chromatography (3% methanol in ethyl acetate) afforded the title compound as a clear oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5337-79-1, 3-(Pyridin-4-yl)acrylic acid.

Reference:
Patent; Merck & Co., Inc.; US6642237; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 5337-79-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5337-79-1, name is 3-(Pyridin-4-yl)acrylic acid. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Compound III-1 (1.5 mmol, 1 eq) and the corresponding compound IV (1.65 mmol, 1.1 eq) were dissolved in DMF (10 mL) and stirred, and then HBTU (1.8 mmol, 1.2 eq) and triethylamine (2.25 mmol, 1.5eq) and reacted at room temperature until compound III-1 was completely reacted. The reaction system was poured into ice water and extracted with DCM to obtain an organic phase. The DCM phase was washed with saturated brine, dried over anhydrous sodium sulfate, and passed through a column with silica gel (200-300 mesh) to obtain the corresponding compound. The specific data are shown in Table 2 below.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5337-79-1, 3-(Pyridin-4-yl)acrylic acid.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Tan Cun; Zhang Xiaofei; Yang Chunhao; Miao Zehong; Song Shanshan; Huan Xiajuan; Chen Yi; Ding Jian; (30 pag.)CN110194762; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem