Category: 5344-27-4

Synthetic Route of 5344-27-4 ,Some common heterocyclic compound, 5344-27-4, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of 2-(pyridin-4-yl)ethan-1-ol (1 g, 8.13 mmol) in THF (30 mL) was added Et3N (1.7 mL, 12.1 mmol) and mesyl chloride (1.1 g, 9.75 mmol) at 0 C and stirred at same temperature for 3 h. The mixture was diluted with cold water (20 mL), adjusted pH to ?7 with saturated aqueous sodium bicarbonate solution and extracted the product with EtOAc (30 mL). The combined organic layer was dried, filtered and evaporated affording a yellow solid (1.1 g, crude). M/z 202.1 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5344-27-4, 4-(2-Hydroxyethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Antabio SAS; The designation of the inventor has not yet been filed; (149 pag.)EP3628672; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5344-27-4 , The common heterocyclic compound, 5344-27-4, name is 4-(2-Hydroxyethyl)pyridine, molecular formula is C7H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 76; N-{5-amino-3-cyano-1-[2, 6-dichloro-4-pentafluorothiophenyl]-1 H-pyrazol-4-yl}-N-(2- pyridin-4-ylethyl) methanesulfonamide; A mixture of Example 38 (200 mg, 0.42 mmol), 4- (2-hydroxyethyl) pyridine (52 mg, 0.42 mmol) and triphenylphosphine (167 mg, 0.64 mmol) in anhydrous tetrahydrofuran (5 ml) was cooled to 0C and diethyl azodicaboxylate (0.1 ml, 0.64 mmol) was added. The reaction mixture was warmed to room temperature and stirred under nitrogen overnight. The reaction mixture was concentrated in vacuo and the residue was partitioned between dichloromethane and water. The organic phase was then separated, dried and concentrated in vacuo. The residue was dissolved in acetonitrile/water (4 ml) and the solution was purified by automated preparative liquid chromatography (Gilson system, 150 x 30 mm, LUNA II C18 10 lim column) using an acetonitrile : 0. 1% trifluoroacetic acid gradient [35: 65 to 95: 5]. The appropriate fractions were concentrated to give the titled compound (55 mg). Experimental MH+ 577.0 ; expected 577.0 ‘H-NMR (CD03) : 2.99-3. 04 (3H), 3.11-3. 18 (2H), 4.12-4. 17 (2H), 4.19-4. 41 (2H), 7.62-7. 69 (2H), 7.86-7. 89 (2H), 8.59-8. 67 (2H)

The synthetic route of 5344-27-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/90313; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem