Category: 5345-47-1

Application of 5345-47-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5345-47-1, name is 2-Aminonicotinic acid, molecular formula is C6H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-aminonicotinic acid (10.0 g, 72 mmol) was dissolved in acetic acid (40 ml),Slowly add bromine (9.64 mL,388 mmol) in acetic acid (20 mL),Stir at room temperature for 2 hours, filter by suction, and wash the filter cake with acetic acid.The cake was recrystallized from methanol,After suction filtration and drying, 14.1 g of a white solid is obtained.The yield is 90%.

According to the analysis of related databases, 5345-47-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shenyang Pharmaceutical University; Ding Huaiwei; Yuan Yue; Huang Qi; Song Hongrui; Zhang Lijuan; (12 pag.)CN104592217; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 5345-47-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5345-47-1, name is 2-Aminonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Containing 13.8 g of 2-amino acid (0.1 mmol) of potassium carbonate and 27.6 g (0.2 mole, 2.0 eq.) Of dimethyl sulfoxide was heated to reflux, then the solution was cooled to ambient temperature, was added 14.2 g of iodine methane (0.1 mole, 1.0 eq) to the mixture, and the solution was stirred for 18 hours, the mixture was filtered and concentrated to give a residual material containing 0.1% aqueous ammonia (5/95 ethanol / dichloromethane) was eluted as after filtration of the liquid silicone pad and the resulting solution was concentrated, the residue was suspended in ether, filtered and dried to give 2-amino-nicotinic acid methyl ester (10.8 g, 71% yield). Analysis of results:

According to the analysis of related databases, 5345-47-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOGEN MA INC.; SUNESIS PHARMACEUTICALS, INC.; ARNDT, JOSEPH; CHAN, TIMOTHY; GUCKIAN, KEVIN; KUMARAVEL, GNANASAMBANDAM; LEE, WEN-CHERNG; LIN, EDWARD YIN-SHIANG; SCOTT, DANIEL; SUN, LIHONG; THOMAS, JERMAINE; VAN VLOTEN, KURT; WANG, DEPING; ZHANG, LEI; ERLANSON, DANIEL; (469 pag.)TWI525093; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5345-47-1, name is 2-Aminonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H6N2O2

Equipped with a blender,Reflux condenser 500mL three-necked flask,20.7 g (0.15 mol) of 2-aminonicotinic acid,80 mL acetic acid,Stirred at room temperature,A constant pressure dropping funnel was added dropwise with a mixed solution of 40 mL of acetic acid and 4.1 mL of bromine (0.08 mol)Drop end to continue mixing 4-5h.filter,Washed with acetic acid,dry,The solid was refluxed with methanol 100mL 10min 10min at room temperature,Filter and dry.31.2g of white solid was obtained,Yield 96%.

With the rapid development of chemical substances, we look forward to future research findings about 5345-47-1.

Reference:
Patent; Southern Medical University; Wan Shanhe; Wang Guangfa; Wu Xiaoyun; Tian Yuanxin; Ye Ling; Li Zhonghuang; Zhang Tingting; Zhu Zhengguang; Jin Hong; Zhang Jiajie; (27 pag.)CN106565684; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 5345-47-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5345-47-1, name is 2-Aminonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

(A) EtOH (500 mL) was added to 2-amino-nicotinic acid (25 g), followed by H2SO4 (25 mL, cone), and the mixture stirred at 75C overnight. The reaction mixture was then redissolved in H2O, neutralized with Na2CO3 (aq), and the resulting precipitate filtered and dried to provide 2-amino-nicotinic acid ethyl ester, which was used without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5345-47-1, 2-Aminonicotinic acid.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BUETTELMANN, Bernd; GOYAL, Bindu; PALMER, Wylie Solang; WO2010/97335; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem