Category: 5349-17-7

Related Products of 5349-17-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, molecular formula is C7H7Br2NO, molecular weight is 280.9446, as common compound, the synthetic route is as follows.

[0234] 7V-(3-Methoxyphenyl)-4-(4-pyridinyl)-l,3-thiazol-2-amine (15). A mixture of bromoketone hydrobromide 1 (1.02 g, 3.62 mmol) and 3- methoxyphenylthiourea (14) (0.66 g, 3.62 mmol) in EtOH (20 mL) was stirred at reflux temperature for 3 h. The mixture was cooled to 20 0C, diluted with water (50 mL), the pH adjusted to ca. 8 with aqueous NH3 and the mixture stirred at 5 0C for 2 h. The precipitate was filtered, washed with water (5 mL) and dried. The crude solid was purified by column chromatography, eluting with a gradient (50-100%) of EtO Ac/pet, ether, to give amine 15 (0.69 g, 68%) as a cream powder: mp (EtOAc/pet. ether) 176-178 0C; 1H NMR delta 10.36 (br s, 1 H, NH), 8.62 (dd, J = 4.5, 1.6 Hz, 2 H, H-2′, H-6′), 7.84 (dd, J= 4.5, 1.6 Hz, 2 H, H-3′, H-5′), 7.71 (s, 1 H, H-5), 7.51 (t, J= 2.2 Hz, 1 H, H-2″), 7.25 (t, J= 8.1 Hz, 1 H, H-5″), 7.18 (br d, J= 8.0 Hz, 1 H, H-4″), 6.56 (br d, J= 8.0 Hz, 1 H, H-6″), 3.79 (s, 3 H, OCH3); 13C NMR delta 163.3, 159.8, 150.1 (2), 147.6, 142.0, 140.9, 129.7, 119.7 (2), 109.4, 107.5, 106.8, 102.7, 54.8; MS m/z 284.5 (MH+, 100%). Anal, calcd for Ci5Hi3N3OS: C, 63.58; H, 4.62; N, 14.83. Found: C, 63.79; H, 4.68; N, 14.87%.

Statistics shows that 5349-17-7 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7Br2NO

a) Preparation of Intermediate 24; A mixture of 2-bromo-1-(4-pyridinyl)-ethanone, hydrobromide (0.02 mol) and (5-chloro-2,4-dimethoxyphenyl)-thiourea (0.02 mol) in EtOH (200 ml) was stirred and refluxed for 4 hours, then cooled to room temperature. The resulting precipitate was filtered off, washed with EtOH and dried, yielding 6.0 g (60%) of intermediate 24 as a hydrobromide salt (.HBr).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; Thuring, Johannes Wilhelmus John F.; MacDonald, Gregor James; Grantham, Christopher James; Dinklo, Theodorus; Lesage, Anne Simone Josephine; US2011/269748; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7Br2NO

Preparation of 2-Methyl-5-nitro-phenyl)-(5-pyridin-4-yl-oxazol-2-yl)-amineTo a solution of 4-bromoacetylpyridine hydrobromide (5 g, 17.8 mmol) in 😯 mL of water was added sodium azide (1.16 g, 17.8 mmol) and the contents stirred at room temperature for 30 min. The reaction mixture was cooled to O0C, treated slowly with saturated aqueous NaHCO3 until pH=6-7, extracted with dichloromethane (3×3 OmL) and the combined organic phases were dried over MgSO4, concentrated at room temperature under reduced pressure to a final volume of 25 mL, and diluted with dioxane (30 mL). The resulting solution was concentrated to remove the remaining EPO (lower boiling) dichloromethane. To the final volume (25 mL) was added at O0C, 2- methyl-5-nitrophenyl isocyanate (1.58 g, 8.9 mmol) (commercially available) and portion wise triphenylphosphine (2.62 g, 8.9 mmol). The reaction mixture was then stirred for 1 h at room temperature and heated for an additional 2 h at 100C. After evaporation of the solvent under reduced pressure the residue was crystallized in dichloromethane/ethanol (10mL/5mL), to give the title compound as yellow crystals (0.9 g, 34%). m p > 220 C

With the rapid development of chemical substances, we look forward to future research findings about 5349-17-7.

Reference:
Patent; AB SCIENCE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); INSTITUT CURIE; WO2006/106437; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5349-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows.

Example 136: 4-(4-Pyridin-4-yl-thiazol-2-ylmethoxy)piperidine-1-carboxylic acid tert-butyl ester A solution of 2-bromo-1-pyridin-4-yl-ethanone hydrobromide (35mg, 124mol) and 4- thiocarbamoylmethoxypiperidine-1-carboxylic acid tert-butyl ester (Preparation 18,34mg, 124Rmol) in methanol (2ml) was heated at 60C for 1. 5h. The reaction mixture was diluted with EtOAc (60ml), washed with saturated aqueous NaHCO3 (15ml) and brine (15ml) then dried (MgSO4). The solvent was removed and the residue purified by flash chromatography (EtOAc) to afford the title compound: RT = 2.95min, mlz (ES+) = 376.1 [M+H] +.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; PROSIDION LIMITED; WO2005/61489; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5349-17-7, blongs to pyridine-derivatives compound. COA of Formula: C7H7Br2NO

(c) Preparation of [(2-chloro-6-nitrophenyl)methyl](4-(4-pyridyl)(1,3-thiazol-2-yl))amine.To a solution of N-({[(2-chloro-6-nitrophenyl)methyl]amino}thioxomethyl)benzamide (Step b) (1.22 g, 3.5 mmol) in 70% aqueous MeOH (50 ML) was added K2CO3 (567 mg, 4.1 mmol) and the reaction was heated to reflux.After 1.5 h, the reaction was cooled (40 C.) and 2-bromo-1-(4-pyridyl)ethan-1-one hydrobromide (992.4 mg, 3.5 mmol) was added.After 1.5 h, the reaction mixture was cooled to RT and purified by flash chromatography with hexanes:EtOAc:CH2Cl2:MeOH (9:1:0:0, 3:1:0:0, 1:1:0:0, 0:0:49:1) as eluant to afford an off-white amorphous solid. MS m/z: 347 (M+1); 345 (M-1). Calc’d for C15H11ClN4O2S-b 346.03.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5349-17-7, its application will become more common.

Reference:
Patent; Huang, Qi; Kaller, Matthew; Nguyen, Thomas; Norman, Mark H.; Rzasa, Robert; Wang, Hui-Ling; Zhong, Wenge; US2003/229068; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5349-17-7, blongs to pyridine-derivatives compound. Product Details of 5349-17-7

General procedure: Potassium carbonate (418 mg, 3 mmol, 1 eq.) was added to a solution of malonitrile (200 mg, 3 mmol, 1 eq.) in dry DMF (5 mL). The reaction was stirred at room temperature for 1 hour and isopropyl isothiocyanate (311 mL, 3 mmol, 1 eq.) was added. After 1 hour stirring at room temperature, 2-bromo-1-(4-methoxyphenyl)ethan-1-one was added (687 mg, 3 mmol, 1 eq.) followed by potassium carbonate (418 mg, 3 mmol, 1 eq.). The mixture was further stirred for 15 hours, and poured into stirring ice/water (50 mL). The resulting precipitate was filtered and washed with water. The title compound was purified by recristalization from hexane/EtOAc and dried under vaccum (823 mg, yield: 87%, purity: 95.7%, Rt = 1.65 min. by method C).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5349-17-7, its application will become more common.

Reference:
Article; Boutard, Nicolas; Sabiniarz, Aleksandra; Czerwi?ska, Klaudia; Jarosz, Ma?gorzata; Cierpich, Anna; Kolasi?ska, Ewa; Wiklik, Katarzyna; Gluza, Karolina; Commandeur, Claude; Buda, Anna; Stasiowska, Agata; Bobowska, Aneta; Galek, Mariusz; Fabritius, Charles-Henry; Bugaj, Marta; Palacz, Edyta; Mazan, Andrzej; Zar?bski, Adrian; Krawczy?ska, Karolina; ?urawska, Ma?gorzata; Zawadzki, Przemys?aw; Milik, Mariusz; W?grzyn, Paulina; Dobrza?ska, Monika; Brzozka, Krzysztof; Kowalczyk, Piotr; Bioorganic and Medicinal Chemistry Letters; vol. 29; 4; (2019); p. 607 – 613;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 5349-17-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, molecular formula is C7H7Br2NO, molecular weight is 280.9446, as common compound, the synthetic route is as follows.

To a solution of 2-Bromo-l-(4-pyridinyl)-l-ethanone hydrobromide (4.0 g, 14.4 mmol) in anhydrous ethanol (80 ml) is added NaBH4 (2.0 g, 52.8 mmol). The reaction mixture is stirred at RT for 2 h. The mixture is filtered and l-(2-Phenylethyl)piperazine (4.9 ml, 26.0 mmol) is added to the filtrate. The solution is heated to reflux and refiuxed for 5 h. Excessive ethanol is removed by distillation. The resulting pale yellow solid is dissolved in chloroform (80 ml), the insoluble parts are filtered off and the filtrate is concentrated by distillation under reduced pressure. The product is purified by chromatography on silica (MeOH/EtOAc, 5:1) to give a pale yellow solid; yield: 32 % ; chemical formula: Ci9H2SN3O; molecular weight: 311,42.1H NMR (300 MHz, CDCl3) delta 2.83 – 2.84 (m, 14H), 4.73 (dd, IH, J= 10.5 Hz, J = 3.8 Hz),7.20 – 7.30 (m, 5H), 7.31 (dd, 2H, J = 4.7 Hz, J = 1.5 Hz), 8.57 (dd, 2H, J = 4.4 Hz, J = 1.5Hz);FT-IR (KBr) 3420, 1639, 1458, 1409, 1128, 854, 696, 622 cm”1;EI MS mZz SlO [M-H+];HR MS m/z calcd for C19H24N3O [M-H+] C9H24N3O 310.191938, found 310.192050.

Statistics shows that 5349-17-7 is playing an increasingly important role. we look forward to future research findings about 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; LEK PHARMACEUTICALS D.D.; WO2007/73935; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide

A solution of 4-(bromoacetyl)pyridine hydrobrornide (2 g, 7. 12 mmol) andthiobenzamide (976 mg, 7.12 rnmol) in absolute EtOH (20 mL) was stirred at 80 C)C for l.Sh,cooled to room temperature, and concentrated in vacuo. The resulting solid was trinLrated withsaturated aqueous potassium carbonate, filtered, washed with water, and dried in vacuo to give1.57 g of the title product as a light pink solid (92% yield): 1 H Ntv1R (DMSO-d6. ppm) o 7.58(m, 3H), 8.03 (d, 2H), 8.08 (dd, 2H), 8.56 (s, l H), 8.70 (d, 2H); [M+H ‘J rn/z 239.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; RUGA CORPORATION; VERNIER, Jean-Michel; O’CONNOR, Patrick; BOUNAUD, Pierre-Yves; HOPKINS, Stephanie; MATTHEWS, David; WO2014/172639; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide

[0332] 7V-(3-Fluorophenyl)-4-(4-pyridinyl)-l,3-thiazol-2-amine (121). Reaction of bromoketone hydrobromide 1 (0.65 g, 2.3 mmol) and 3-fluorophenylthiourea (120) (0.39 g, 2.3 mmol) gave amine 121 (0.45 g, 71%) as a white powder: mp (EtOAc/pet. ether) 229-230 0C; 1H NMR delta 10.59 (br s, 1 H, NH), 8.63 (dd, J = 4.5, 1.6 Hz, 2 H, H-2′, H-6′), 7.35 (dd, J= 4.5, 1.6 Hz, 2 H, H-3′, H-5′), 7.28-7.31 (m, 1 H, H-2″), 7.76 (s, 1 H, H-5), 7.34-7.41 (m, 2 H, H-5″, H-6″), 6.77-6.84 (m, 1 H, H-4″); 13C NMR delta 163.0, 162.4 (d, J= 240 Hz), 150.1 (2), 147.6, 142.4 (d, J = 11 Hz), 140.8, 130.5 (d, J= 10 Hz), 119.8 (2), 112.7 (d, J= 2 Hz), 108.0, 107.5 (d, J= 21 Hz), 103.5 (d, J= 26 Hz). Anal, calcd for Ci4Hi0FN3S: C, 61.98; H, 3.72; N, 15.49. Found: C, 61.91; H, 3.79; N, 15.20%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 5349-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows.

[0246] 7V-{4-[2-(Dimethylamino)ethoxy]phenyl}-4-(4-pyridinyl)-l,3-thiazol- 2-amine (29). A mixture of bromoketone hydrobromide 1 (0.63 g, 2.25 mmol) and l-(4-(2-(dimethylamino)ethoxy)phenyl)thiourea (28) (0.54 g, 2.25 mmol) in EtOH (20 mL) was stirred at reflux temperature for 2 h. The mixture was cooled to 20 0C, diluted with water (50 mL), the pH adjusted to ca. 8 with aqueous NH3 and the mixture stirred at 0 0C for 1 h. The precipitate was filtered, washed with water (5 mL), and dried. The crude solid was purified by column chromatography, eluting with a gradient (0-20%) of MeOH/EtOAc, followed by 1% aqueous NH3/MeOH/EtOAc, to give amine 29 (447 mg, 58%) as a an oil: 1H NMR delta 10.13 (s, 1 H, NH), 8.60 (dd, J= 4.5, 1.6 Hz, 2 H, H-2′, H-6′), 7.83 (dd, J= 4.5, 1.6 Hz, 2 H, H-3′, H-5′), 7.59-7.64 (m, 3 H, H-5, H-2″, H-6″), 6.95 (ddd, J= 9.0, 3.5, 2.2 Hz, 2 H, H-3″, H-5″), 4.02 (br t, J= 5.9 Hz, 2 H, CH2O), 2.61 (br t, J= 5.9 Hz, 2 H, CH2N), 2.22 [s, 6 H, N(CH3)3]; 13C NMR delta 164.0, 153.4, 150.0 (2), 147.6, 141.0, 134.4, 119.8 (2), 118.7 (2), 114.8 (2), 106.6, 66.0, 57.6, 45.4 (2); MS m/z341.5 (MH+, 100%).

According to the analysis of related databases, 5349-17-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem