Category: 5349-17-7

Adding a certain compound to certain chemical reactions, such as: 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H7Br2NO, blongs to pyridine-derivatives compound. HPLC of Formula: C7H7Br2NO

EXAMPLE 13 [6-CHLORO-3-(1H-1,2,3,4-TETRAZOL-5-YLMETHYL)-1H-INDOL-2-YL](4-PYRIDINYL)METHANONE The title compound was prepared according to the procedure described in step 5 of Example 1 from N-(5-chloro-2-{(E)-2-[1-(2-cyanoethyl)-1H-1,2,3,4-tetrazol-5-yl]ethenyl}phenyl)benzenesulfonamide (Example 1, step 4) and 4-bromoacetylpyridine hydrobromide (L. W. Deady, M. S. Stanborough, Aust. J. Chem., 1981, 34 , 1295). MS (EI) m/z: 338 (M+). IR (KBr) nu: 3246, 2870, 1637, 1526, 1439, 1323, 1248, 943, 841. 1H-NMR (DMSO-d6) delta: 11.92 (1H, s), 8.80 (2H, d, J=4.5 Hz), 7.68 (1H, d, J=8.7 Hz), 7.63 (2H, d, J=4.5 Hz), 7.51 (1H, d, J=1.8 Hz), 7.15 (1H, dd, J=1.8, 8.7 Hz), 4.58 (2H, s).

The synthetic route of 5349-17-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; EP1065206; (2001); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, molecular formula is C7H7Br2NO, molecular weight is 280.9446, as common compound, the synthetic route is as follows.Application In Synthesis of 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide

[0342] l-(4-{[4-(4-Pyridinyl)-l,3-thiazol-2-yl]amino}phenyl)ethanone (131). A mixture of bromoketone hydrobromide 1 (0.60 g, 2.14 mmol) and 4- acetylphenylthiourea (130) (0.41 g, 2.14 mmol) in EtOH (20 mL) was stirred at reflux temperature for 3 h. The mixture was cooled to 20 0C, diluted with water (50 mL), the pH adjusted to ca. 8 with aqueous NH3 and the mixture stirred at 20 0C for 2 h. The precipitate was filtered, washed with water (5 mL) and dried. The crude solid was purified by column chromatography, eluting with 50% EtO Ac/pet, ether, to give amine 131 (0.40 g, 64%) as a cream powder: mp (EtO Ac/pet, ether) 229-231 0C; 1H NMR delta 10.80 (br s, 1 H, NH), 8.63 (dd, J= 4.5, 1.6 Hz, 2 H, H- 2″‘, H-6′”), 8.01 (br d, J= 8.8 Hz, 2 H, H-2′, H-6’), 7.89 (dd, J= 4.5, 1.6 Hz, 2 H, H-3″‘, H-5″‘), 7.85 (br d, J= 8.8 Hz, 2 H, H-3′, H-5’), 7.82 (s, 1 H, H-5″), 2.53 (s, 3 H, H-2); 13C NMR delta 195.9, 162.5, 150.1 (2), 147.7, 144.8, 140.7, 129.8 (2), 119.8 (2), 116.0 (2), 108.7, 26.1, one carbon not observed. Anal, calcd for Ci6Hi3N3OS: C, 65.06; H, 4.44; N, 14.23. Found: C, 65.11; H, 4.40; N, 14.13%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem