Category: 5350-93-6

5350-93-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5350-93-6, name is 6-Chloropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: Preparation of ( 6-chloro-pyridin-3-yl) -carbamic acid tert-butyl ester; 6-Chloro-pyridin-3-ylamine (10.0 g) were dissolved in tert- butanol (140 mL) , di-tert-butyl dicarbonate (18.7 g) were added and the solution was stirred at 500C for 4 h. Di- tert-butyl dicarbonate (3.40 g) was added and the reaction mixture was stirred for another 8 h at 5O0C. Most of the solvent was removed in vacuum and the residue was dissolved in ethyl acetate and washed 3x with water, washed with brine, dried over magnesium sulfate and concentrated in vacuum. The residue was purified by column chromatography (silica 60, chloroform/ethyl acetate 10:1, Rf = 0.30) to afford 16.5 g of the title compound of the formulaas a white solid .1H-NMR (CDCl3, TMS) delta (ppm) : 1.52 (9H, s), 6.54 (IH, br s), 7.27 (IH, d, J = 3 Hz), 7.96 (IH, s), 8.23 (IH, d, J = 3 Hz) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5350-93-6, 6-Chloropyridin-3-amine.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2008/130021; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5350-93-6 , The common heterocyclic compound, 5350-93-6, name is 6-Chloropyridin-3-amine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

b) Preparation of 5 -bromo-2-chloro-pyridine. 6-Chloro-pyridin-3-ylamine (15 g, 117 mmol) was dissolved slowly with constant stirring in 48percent HBr solution (50 mL) at r.t. and then the solution was chilled to -10 ¡ãC. A solution of sodium nitrite (8.9 g, 129 mmol) in cold water (25 mL) was added dropwise at -10 ¡ãC with constant stirring over 2 h, followed by a solution of copper (I) bromide (25 g, 176 mmol) in 48percent HBr (40 mL) dropwise. The mixture was- then stirred at r.t. until complete. The mixture was neutralised with sodium carbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over soldium sulfate and concentrated. The residue was purified by column chromatography on silica gel (60-120 mesh) eluting with 1percent ethyl acetate/petroleum ether to afford 5- bromo-2-chloro-pyridine (ll.l g, 49percent).

According to the analysis of related databases, 5350-93-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F2G LTD; WO2008/62182; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5350-93-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5350-93-6, name is 6-Chloropyridin-3-amine, the common compound, a new synthetic route is introduced below.

Sodium nitrite (3.45g, 0.05mol) was added portion wise to a stirred solution of 6- chloro-pyridin-3-ylamine (6.4g, 0.05mol) in acetic acid (56ml) and HCl (cone)(9.92ml) while maintaining the temperature below 15¡ãC. This solution was then added drop wise to a stirred solution of sulfur dioxide (17.2g, 0.27mol), copper (II) chloride (1.85g, 0.01 lmol) and water (2.2ml) in acetic acid (37ml) at 5¡ãC. The reaction mixture was allowed to warm to room temperature and poured over ice water and stirred for a further 15min. The resultant precipitate was collected by filtration, washed with water and dried overnight in a vacuum oven to give 6- chloro-pyridine-3-sulfonyl chloride (6.41g, 60.5percent yield); (400 MHz; d6-DMSO) 8.54 (IH, d), 7.96 (IH, dd), 7.50 (IH, d).

Statistics shows that 5350-93-6 is playing an increasingly important role. we look forward to future research findings about 6-Chloropyridin-3-amine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/49605; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5350-93-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5350-93-6, name is 6-Chloropyridin-3-amine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Bromine (24.86 g, 155.57 mmol) was added to a solution of 6-chloropyridin-3-amine (20.00 g, 155.57 mmol) and sodium acetate (25.52 g, 311.14 mmol) in acetic acid (383 ml). The reaction mixture was stirred at room temperature for 1 hour. Acetic acid was then evaporated. The residue was dissolved in EtOAc, washed with saturated aqueous Na2CO3, water and brine. The organic layer was dried over MgSO4, filtered and evaporated, yielding 32.20 g of the desired product 49-a (99.8%). m/z=206.96 (M+1)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5350-93-6, 6-Chloropyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jansen R&D Ireland; Tahri, Abdellah; Jonckers, Tim Hugo Maria; Raboisson, Pierre Jean-Marie Bernard; Vendeville, Sandrine Marie Helene; Hu, Lili; Demin, Samuel Dominique; Cooymans, Ludwig Paul; US2015/111868; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5350-93-6, Adding a certain compound to certain chemical reactions, such as: 5350-93-6, 6-Chloropyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5350-93-6, blongs to pyridine-derivatives compound.

Step a: (6-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester To a mixture of 6-chloropyridin-3-amine (30.0 g, 0.23 mol), DMAP (1 g) and Et3N (41.7 g, 0.47 mol) in CH2Cl2 (200 mL) was added Boc2O (54.5 g, 0.25 mol) at 0 C. The mixture was allowed to warm to room temperature and stirred overnight. The mixture was washed with saturated NaHCO3 solution. The aqueous solution was extracted with dichloromethane. The combined organics were washed with brine (100 mL), dried over Na2SO4 and evaporated under vacuum to give tert-butyl 6-chloropyridin-3-ylcarbamate (50.0 g, 94%), which was used directly in the next reaction. 1H NMR (300 MHz, CDCl3) delta 8.23 (d, J=2.7 Hz, 1H), 7.97 (d, J=6.9 Hz, 1H), 7.27-7.24 (m, 1H), 6.58 (s, 1H), 1.52 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5350-93-6, its application will become more common.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; US2009/253736; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5350-93-6, 6-Chloropyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5350-93-6, blongs to pyridine-derivatives compound. 5350-93-6

6-Chloro-pyridine-3-sulfonyl chloride; Sodium nitrite (3.45g, 0.05mol) was added portion wise to a stirred solution of 6- chloro-pyridin-3-ylamine (6.4g, 0.05mol) in acetic acid (56ml) and HCl (cone) (9.92ml) while maintaining the temperature below 15¡ãC. This solution was then added drop wise to a stirred solution of sulfur dioxide (17.2g, 0.27mol), copper (II) chloride (1.85g, 0.01 lmol) and water (2.2ml) in acetic acid (37ml) at 5¡ãC. The reaction mixture was allowed to warm to room temperature and poured over ice water and stirred for a further 15min. The resultant precipitate was collected by filtration, washed with water and dried overnight in a vacuum oven to give 6- chloro-pyridine-3-sulfonyl chloride (6.41g, 60.5percent yield); (400 MHz; d6-DMSO) 8.54 (IH, d), 7.96 (IH, dd), 7.50 (IH, d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5350-93-6, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/138594; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5350-93-6, name is 6-Chloropyridin-3-amine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.5350-93-6

A mixture of pyridine 20 (5.37 g, 41.9 mmol) and Boc2O (8.56 g, 46.1 mmol) in DMF (25 mL) and DIEA (5 mL) was stirred at RT for 4 hr, then at 60C for 16 hr. The solution was diluted with AcOEt (300 mL) and was washed with 10% aqueous K2CO3 (2x, each 100 mL). The organic layer was dried [(MGS04)] and evaporated to give compound 21 (8.27 g, [87%, 1H-NMR).]

Statistics shows that 5350-93-6 is playing an increasingly important role. we look forward to future research findings about 6-Chloropyridin-3-amine.

Reference:
Patent; GENESOFT PHARMACEUTICALS, INC.; WO2004/12736; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem