Electric Literature of 5371-70-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5371-70-0, name is Dimethyl 4-chloropyridine-2,6-dicarboxylate. A new synthetic method of this compound is introduced below.
Sodium iodide (39 g, 262 mmol) was added to a solution of compound 10 (6.0 g, 26.2 mmol) in anhydrous acetonitrile (140 mL) and the mixture was ultrasonicated for 20 minutes. Acetyl chloride (5.55 mL, 78.6 mmol) was added to this mixture, and the mixture was ultrasonicated for 5 hours. Saturated sodium bicarbonate solution (75 mL) was added to this solution, cooled to 0 C., followed by addition of water (100 mL). The mixture was extracted with ethyl acetate (2¡Á50 mL) and the organic phases were combined, washed with 0.2 M thiosulfate solution and finally dried over sodium sulfate, filtered and then concentrated under reduced pressure. Methanol (40 mL) was added to this residue, and the mixture was stirred for 20 minutes and then filtered to give a white solid identified as compound 11. The product was sufficiently pure to be used in the rest of the synthesis without further purification (6.9 g, 82%). 1H NMR (300 MHz, CDCl3) delta: 8.68 (s, 2H), 4.05 (s, 6H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5371-70-0, its application will become more common.
Reference:
Patent; CISBIO BIOASSAYS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; ECOLE NORMALE SUPERIEURE DE LYON; Lamarque, Laurent; Maury, Olivier; Parker, David; Zwier, Jurriaan; Walton, James W.; Bourdolle, Adrien; US2014/336373; (2014); A1;,
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