Category: 53939-30-3

In 2018,Zeng, Yu; Zheng, Hao-liang; Yang, Zhao; Liu, Cheng-Kou; Fang, Zheng; Guo, Kai published 《Copper(I) Iodide-Catalyzed (Het)arylation of Diethyl Malonate with (Het)aryl Bromides by Using 1,3-Benzoxazole as a Ligand》.Synlett published the findings.Computed Properties of C5H3BrClN The information in the text is summarized as follows:

An efficient Ullmann-type coupling of aryl bromides with di-Et malonate in the presence of copper(I) iodide and 1,3-benzoxazole is presented. This method has a broad substrate scope (heterocyclic and Ph bromides) and good functional-group tolerance (OMe, Me, Ac, CN, NO2, F, and Cl). Moreover, less time is needed to reach full conversion (3-9 h). In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Computed Properties of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 53939-30-3In 2019 ,《Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines》 appeared in ACS Omega. The author of the article were Sun, Chao; Yao, Wubing; Chen, Xu; Zhao, Yiwen; Wei, Qiqi; Chen, Zishuang; Wu, Jiashou; Hao, Feiyue; Xie, Huiping. The article conveys some information:

An environmental, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides, to 2- aminopyridine derivatives I (X = 5-Br, 3-Br, 4-Cl, etc.; R = H, Me; R1 = Me, n-Bu, n-hexyl, Bn, etc.) using water as solvent has been developed. Featuring the use of the new method, the reaction is extended to the transformation on a large scale. Mechanistic studies indicate that the pathway involving a base aidant dissociation of N,N-dimethylformamide to generate the dimethylamine is likely. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Application of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Hu, Ping; Wang, Xinghui; Zhang, Baiqun; Zhang, Shuai; Wang, Qiang; Wang, Zhiyong published 《Fluorescence Polarization for the Evaluation of Small-Molecule Inhibitors of PCAF BRD/Tat-AcK50 Association》.ChemMedChem published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A fluorescence polarization competitive assay was developed to efficiently screen and evaluate inhibitors of PCAF bromodomain/Tat-AcK50 protein-peptide interaction. A series of pyridine 1-oxide derivatives were synthesized and evaluated. Some of the novel compounds, 2-(3-aminopropylamino) pyridine 1-oxide derivatives, could be effective inhibitors of PCAF bromodomain/Tat-AcK50 association Specifically, 2-(3-aminopropylamino)-5-(hydroxymethyl)pyridine 1-oxide hydrochloride (15) and the 5-((3-aminopropylamino)methyl) derivative (20) were found to be effective ligands for the PCAF BRD pocket. First preliminary cellular studies indicate that these small-mol. inhibitors have lower cytotoxicities and are potential leads for the anti-HIV/AIDS therapeutic strategy by targeting host-cell protein PCAF BRD to block HIV replication. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Abel, Anton S.; Averin, Alexei D.; Buryak, Alexei K.; Savelyev, Evgenii N.; Orlinson, Boris S.; Novakov, Ivan A.; Beletskaya, Irina P. published 《The Palladium-Catalyzed Heteroarylation of Adamantylalkyl Amines with Dihalogenopyridines: Scope and Limitations》.Synthesis published the findings.SDS of cas: 53939-30-3 The information in the text is summarized as follows:

Palladium-catalyzed heteroarylation of adamantylalkyl amines characterized by different steric hindrances at the amino group was carried out using 2,3-, 2,5-, 2,6-, and 3,5-dihalogenopyridines. The dependence of the results of the coupling on the nature of the halogen atoms (bromine, chlorine), their position in the pyridine ring, and on the structure of adamantylalkyl amines was investigated. The application of dichloropyridines or bromochloropyridines was shown to be advantageous over the use of dibromopyridines in many cases. Selective substitution of bromine atom in positions 3 and 5 in the presence of chlorine atom in position 2 of the pyridine ring was observed The possibility of N,N-diheteroarylation of adamantane-containing amines with 2,5-dihalogenopyridines was shown, and diamination of 2,6- and 3,5-dihalogenopyridines was demonstrated.5-Bromo-2-chloropyridine(cas: 53939-30-3SDS of cas: 53939-30-3) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Science included an article by Jin, Bo; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H.. Safety of 5-Bromo-2-chloropyridine. The article was titled 《ppm Pd-catalyzed, Cu-free Sonogashira couplings in water using commercially available catalyst precursors》. The information in the text is summarized as follows:

A new catalyst was developed for copper-free, Pd-catalyzed Sonogashira reactions at the sustainable ppm level of precious metal palladium under mild aqueous micellar conditions. Both the palladium pre-catalyst and ligand are com. available, bench stable, and highly cost-effective. The catalyst is applicable to reactions of both aryl- and heteroaryl bromides. A wide range of functional groups are tolerated and the aqueous reaction medium can be recycled. An application of this procedure to the synthesis of a key intermediate to an active pharmaceutical ingredient (ponatinib) is discussed. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Carbazole-bridged NCN-pincer palladium complex catalyzed direct C-H arylation reaction of azoles》 was published in Youji Huaxue in 2020. These research results belong to Song, Wenyue; Rao, Xiaofeng; Bu, Qingqing; Liu, Ning. Electric Literature of C5H3BrClN The article mentions the following:

A new type of pincer palladium complexes C1∼C6 based on the strong donor strength of carbazoles skeleton were synthesized. The air- and moisture-stable complexes C1∼C6 act as efficient catalysts for the direct arylation of azoles with (hetero)aryl bromides in good to excellent yields with broad substrate scope used KOAc as sole base under aerobic conditions. It was demonstrated that this developed protocol was used as catalytic system for the direct C-H bond arylation of thiazoles under relatively mild reaction conditions at a low catalyst loading of 0.5 mol%. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Everson, Daniel A.; Buonomo, Joseph A.; Weix, Daniel J. published 《Nickel-catalyzed cross-electrophile coupling of 2-chloropyridines with alkyl bromides》.Synlett published the findings.Product Details of 53939-30-3 The information in the text is summarized as follows:

The synthesis of 2-alkylated pyridines by the nickel-catalyzed cross-coupling of two electrophiles, a 2-chloropyridine and an alkyl bromide, is described. Compared with previous published conditions for aryl halides, this method uses a different, more rigid, bathophenanthroline ligand and is conducted at high concentration in N,N-dimethylformamide as solvent. The method displays promising functional group compatibility and the conditions are orthogonal to those for the Stille coupling. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Hu, Li-Qun; Deng, Rong-Li; Li, Yan-Fen; Zeng, Cui-Jin; Shen, Dong-Sheng; Liu, Feng-Shou published 《Developing Bis(imino)acenaphthene-Supported N-Heterocyclic Carbene Palladium Precatalysts for Direct Arylation of Azoles》.Organometallics published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

From the strategy of developing highly efficient protocol for Pd-catalyzed cross-coupling reactions, bulky bis(imino)acenaphthene (BIAN)-supported Pd-PEPPSI complexes were synthesized, characterized and applied in direct arylation of azoles. The effect of backbone and N-moieties on NHCs was evaluated and the reaction conditions were optimized. The bulky Pd-PEPPSI complexes could be successfully employed in cross-coupling of (hetero)aryl bromides with azoles at a low Pd loading of 0.5-0.05 mol% under aerobic conditions, demonstrating the ease of manipulation without glovebox and handling of solvents. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Category: pyridine-derivatives)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 5-Bromo-2-chloropyridineIn 2022 ,《Tandem Synthesis of 1,2,3-Thiadiazoles with 3,4-Dichloroisothiazoles and Hydrazines under External Oxidant- and Sulfur-free Conditions》 was published in Organic Letters. The article was written by Zhang, Yue; Li, Kun; Gao, Wei; Liu, Xiaoyu; Yuan, Haolin; Tang, Liangfu; Fan, Zhijin. The article contains the following contents:

1,2,3-Thiadiazoles are among the most important heterocyclic motifs with wide applications in natural products and medicinal chem. Herein, authors disclosed a tandem reaction for the synthesis of structurally diverse 1,2,3-thiadiazoles from 3,4-dichloroisothiazol-5-ketones and hydrazines. This method is characterized by free of external oxidants or sulfur requirements, mild reaction conditions, broad substrate scope and easy purification5-Bromo-2-chloropyridine(cas: 53939-30-3Quality Control of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Quality Control of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 53939-30-3In 2015 ,《Modular, Concise, and Efficient Synthesis of Highly Functionalized 5-Fluoropyridazines by a [2 + 1]/[3 + 2]-Cycloaddition Sequence》 appeared in Organic Letters. The author of the article were Tran, Gael; Gomez Pardo, Domingo; Tsuchiya, Tomoki; Hillebrand, Stefan; Vors, Jean-Pierre; Cossy, Janine. The article conveys some information:

An easy access to 5-fluoropyridazines by a [2+1]/[3+2]-cycloaddition sequence between terminal alkynes, a difluorocarbene, and a diazo compound is reported. This approach does not necessitate the isolation of any intermediates, and a wide range of novel 5-fluoropyridazines, e.g., I (R1 = Ph, 2-MeOC6H4, cyclopropyl, etc., R2 = Et, PhCH2, Me3C), was synthesized from readily available starting materials. Addnl., these compounds were used as a platform to access novel and highly diversified pyridazines. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3Application of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem