Category: 53939-30-3

Sun, Deli; Ma, Guobin; Zhao, Xinluo; Lei, Chuanhu; Gong, Hegui published their research in Chemical Science in 2021. The article was titled 《Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides》.Formula: C5H3BrClN The article contains the following contents:

An asym. Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones I [R1 = Me, Ph, 2-thienyl, etc.; R2 = Me, n-Bu, Bn, etc.; Ar = 4-MeOOCC6H4, 2-methoxy-pyridin-5-yl, 2-naphthyl, etc.] was reported. The reaction tolerated a variety of functional groups under mild reaction conditions, which complements current methods. The utility of this work was demonstrated by facile late-stage functionalization of com. drugs.5-Bromo-2-chloropyridine(cas: 53939-30-3Formula: C5H3BrClN) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Nicolas, Lionel; Angibaud, Patrick; Stansfield, Ian; Meerpoel, Lieven; Reymond, Sebastien; Cossy, Janine published 《Copper-catalysed amidation of 2-chloro-pyridinesã€?RSC Advances published the findings.Recommanded Product: 53939-30-3 The information in the text is summarized as follows:

The simple and inexpensive N,N-dimethylcyclohexane-1,2-diamine/CuI catalytic system provides a versatile, easy and efficient access to an array of N-(2-pyridin-2-yl)-amides from 2-chloro-pyridine derivatives In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,ChemCatChem included an article by Chan, Vincent S.; Krabbe, Scott W.; Li, Changfeng; Sun, Lijie; Liu, Yue; Nett, Alex J.. Computed Properties of C5H3BrClN. The article was titled 《Identification of an Oxalamide Ligand for Copper-Catalyzed C-O Couplings from a Pharmaceutical Compound Libraryã€? The information in the text is summarized as follows:

The use of pharmaceutical compound library approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that was generally effective for copper-catalyzed C-O cross-couplings to prepare both biarylethers as well as phenols under mild conditions. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Computed Properties of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Lafaye, Kevin; Nicolas, Lionel; Guerinot, Amandine; Reymond, Sebastien; Cossy, Janine published 《Lewis Basicity Modulation of N-Heterocycles: A Key for Successful Cross-Metathesisã€?Organic Letters published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

Introducing a chloro or other substituent neighboring the nitrogen atom of azaheterocycle-containing alkenes decreased their Lewis basicity sufficiently that, in most cases, they underwent olefin cross-metathesis with alkenes such as Me acrylates and (Z)-2-butene-1,4-diol diacetate in the presence of the second-generation Hoveyda-Grubbs ruthenium metathesis catalyst to give azaheteroaryl-substituted alkenes diastereoselectively. A variety of electron-deficient and electron-rich olefins and styrenes underwent metathesis, while chloro-, bromo-, fluoro-, trifluoromethyl-, trifloxy-, methoxy-, and tert-butyl-substituted pyridinylalkenes and chloro-substituted pyrimidinyl, isoquinolinyl, imidazolyl, and pyrazolyl alkenes were effective metathesis substrates. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Hyde, Alan M.; Liu, Zhijian; Kosjek, Birgit; Tan, Lushi; Klapars, Artis; Ashley, Eric R.; Zhong, Yong-Li; Alvizo, Oscar; Agard, Nicholas J.; Liu, Guiquan; Gu, Xiuyan; Yasuda, Nobuyoshi; Limanto, John; Huffman, Mark A.; Tschaen, David M. published 《Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reductionã€?Organic Letters published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

A scalable and efficient synthesis of the GPR40 agonist MK-8666 was developed from a simple pyridine building block. The key step to set the stereochem. at two centers relied on an enzymic dynamic kinetic reduction of an unactivated ketone. Directed evolution was leveraged to generate an optimized ketoreductase that provided the desired trans alc. in >30:1 dr and >99% ee. Further, it was demonstrated that all four diastereomers of this hydroxy-ester could be prepared in high yield and selectivity. Subsequently, a challenging intramol. displacement was carried out to form the cyclopropane ring system with perfect control of endo/exo selectivity. The endgame coupling strategy relied on a Pd-catalyzed C-O coupling to join the headpiece chloropyridine with the benzylic alc. tailpiece. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 5-Bromo-2-chloropyridineIn 2017 ,《Sequential one pot double C-H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes》 was published in Tetrahedron. The article was written by Kieffer, Charline; Babin, Victor; Jouanne, Marie; Slimani, Ikram; Berhault, Yohann; Legay, Remi; Sopkova-de Oliveira Santos, Jana; Rault, Sylvain; Voisin-Chiret, Anne Sophie. The article contains the following contents:

We present C-H heteroarylation reactions between thiophene and variously substituted bromopyridines. The objective was to synthesize unsym. 2,5-bipyridylthiophenes. We studied the reaction conditions allowing to a sequential one-pot double C-H heteroarylation, in a view to introduce two different pyridyl moieties at positions 2 and 5 of the thiophene ring using bromopyridines. 11 original unsym. 2,5-bipyridylthiophenes were synthesized and characterized, including 2,5-di(pyridin-2-yl)thiophenes for which the preparation by classical cross-coupling reactions is challenging. Finally, with the addnl. synthesis of both an unsym. 2,5-biarylthiophene and an original pyrimidin-thiophene-furan scaffold, we shown that our methodol. was also an efficient tool to access to new heterocyclic sequences. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions》 was written by Song, A-Xiang; Zeng, Xiao-Xiao; Ma, Bei-Bei; Xu, Chang; Liu, Feng-Shou. Synthetic Route of C5H3BrClNThis research focused onunsym palladium heterocyclic carbene PEPPSI complex preparation arylation catalyst; crystal structure unsym palladium heterocyclic carbene PEPPSI type complex; mol structure unsym palladium heterocyclic carbene PEPPSI type complex; palladium carbene catalyzed heteroarylation heteroarene; muscle relaxant drug dantrolene conjugated mesopolymer preparation. The article conveys some information:

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsym. Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The use of this unsym. strategy led to much higher efficiency in comparison to the commonly used C2-sym. Pd-PEPPSI-type NHC complexes. Also, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at ≥0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with the authors’ study, also the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Synthetic Route of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Synthetic Route of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source》 was written by Xu, Yiwen; Shen, Bei; Liu, Lingfeng; Qiao, Chunhua. Name: 5-Bromo-2-chloropyridineThis research focused ontriazolopyridine preparation; hydrazinylpyridine amide annulation imidazolium chloride catalyst; triazine preparation; biguanide amide annulation imidazolium chloride catalyst. The article conveys some information:

A highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare 1,2,4-triazolo[3,4-a]pyridines, e.g., I and triazines II [R = H, Me, Ph, 2-MeC6H4, 3-ClC6H4; R1 = H, Me; RR1 = (CH2)2O(CH2)2; R2 = H, Ph] was reported. This metal free reaction took advantages of shelf stable DMF as solvent and carbon donor, imidazolium chloride as a catalyst, the mild reaction condition tolerated a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allowed further introduction of a variety of functional groups at 3-position.5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Ryan, Sarah J.; Schimler, Sydonie D.; Bland, Douglas C.; Sanford, Melanie S. published 《Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro- and Nitroarenes》.Organic Letters published the findings.COA of Formula: C5H3BrClN The information in the text is summarized as follows:

The reaction of acid fluorides with N-heterocyclic carbenes (NHCs) produces anhydrous acyl azolium fluorides. With appropriate selection of the acid fluoride and NHC, these salts can be used for the room temperature SNAr fluorination of a variety of aryl chlorides and nitroarenes. E.g., in presence of N-heterocyclic carbene (I) and 4-MeOC6H4COF, fluorination of aryl chloride (II) gave 99% aryl fluoride (III). In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Deutsch, Amrei; Jessen, Christoph; Deutsch, Carl; Karaghiosoff, Konstantin; Hoffmann-Roeder, Anja published 《One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles》.Organic Letters published the findings.Recommanded Product: 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

An operationally simple one-pot reaction for the preparation of a novel class of racemic trifluoromethylated 2,3-dihydro-1H-imidazoles derived from electron-poor N,O-acetals and aryl Grignard reagents is described. In addition, access to highly functionalized 2-trifluoromethyl-2,3-dihydro-1H-imidazoles was accomplished by reaction of N-aryl hemiaminal ethers and N-aryl trifluoroethylamines in the presence of an excess of n-butyllithium. In the part of experimental materials, we found many familiar compounds, such as 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem