Category: 53939-30-3

In 2017,Duong, Hung A.; Wu, Wenqin; Teo, Yu-Yuan published 《Cobalt-Catalyzed Cross-Coupling Reactions of Arylboronic Esters and Aryl Halides》.Organometallics published the findings.Computed Properties of C5H3BrClN The information in the text is summarized as follows:

An efficient cobalt catalyst system for the Suzuki-Miyaura cross-coupling reaction of arylboronic esters and aryl halides has been identified. In the presence of cobalt(II)/terpyridine catalyst and potassium methoxide, a diverse array of (hetero)biaryls have been prepared in moderate to excellent yields. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3Computed Properties of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Wagner, Patrick; Bollenbach, Maud; Doebelin, Christelle; Bihel, Frederic; Bourguignon, Jean-Jacques; Salome, Christophe; Schmitt, Martine published 《t-BuXPhos: a highly efficient ligand for Buchwald-Hartwig coupling in water》.Green Chemistry published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

An efficient and versatile ‘green’ catalytic system for the Buchwald-Hartwig cross-coupling reaction in water is reported. In an aqueous micellar medium, the combination of t-BuXPhos with [(cinnamyl)PdCl]2 showed excellent performance for coupling of aryl bromides or chlorides with a large set of amines, amides, ureas, and carbamates. The method is functional-group tolerant, proceeds smoothly (30 to 50 °C), and provides rapid access to the target compounds in good to excellent isolated yields. When applied to the synthesis of a known NaV1.8 modulator, this method led to a significant improvement of the E-factor in comparison with classical organic synthesis. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Huang, Liangbin; Weix, Daniel J. published 《Ruthenium-Catalyzed C-H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides》.Organic Letters published the findings.Safety of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was shown to be a stronger donor than an amide, and the arylation of a pyridine carboxylate was demonstrated. Stoichiometric studies demonstrated that the added ligand is required for reaction with the electrophile but not the C-H bond. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Isley, Nicholas A.; Wang, Ye; Gallou, Fabrice; Handa, Sachin; Aue, Donald H.; Lipshutz, Bruce H. published 《A Micellar Catalysis Strategy for Suzuki-Miyaura Cross-Couplings of 2-Pyridyl MIDA Boronates: No Copper, in Water, Very Mild Conditions》.ACS Catalysis published the findings.Recommanded Product: 53939-30-3 The information in the text is summarized as follows:

Suzuki-Miyaura cross-coupling of 2-pyridyl N-methyliminodiacetic acid (MIDA) boronates with aryl chlorides and bromides was carried out in the complete absence of copper by attenuation of the Lewis basicity associated with the pyridyl nitrogen using selected substituents (e.g., fluorine or chlorine) on the ring. Coupling of substituted 2-pyridinyl MIDA boronates was performed using Pd(dtbpf)Cl2 as catalyst and DIPEA in an aqueous micellar suspension of the surfactant TPGS-750-M. Dehalogenation of the halopyridines using Ni(OAc)2 and 1,10-phenanthroline as catalysts and pyridine and NaBH4, Suzuki-Miyaura coupling with aryl or heteroaryl bromides in the absence of addnl. palladium catalyst, or nucleophilic aromatic substitution of the halopyridines with dimethylamine or morpholine yielded substituted pyridines. Computational data suggest that the major role played by electron-withdrawing substituents in promoting Suzuki-Miyaura cross-couplings of 2-pyridinyl MIDA boronates in the absence of copper is to slow the rate of protodeboronation of the intermediate 2-pyridylboronic acids. 2-Pyridinylboronic acids were generated by controlled release of 2-pyridinyl MIDA boronates in D2O and underwent protodeboronation slowly under those conditions. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Diversity-Oriented Enzymatic Synthesis of Cyclopropane Building Blocks》 was published in ACS Catalysis in 2020. These research results belong to Wittmann, Bruce J.; Knight, Anders M.; Hofstra, Julie L.; Reisman, Sarah E.; Jennifer Kan, S. B.; Arnold, Frances H.. Electric Literature of C5H3BrClN The article mentions the following:

While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts can be used to help generate diverse building blocks for drug discovery. Here we show the engineering of two variants of Rhodothermus marinus nitric oxide dioxygenase (RmaNOD) to catalyze the formation of cis- and trans-diastereomers of a pinacolboronate-substituted cyclopropane which can be readily derivatized to generate diverse stereopure cyclopropane building blocks. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bag, Sukdev; Jana, Sadhan; Pradhan, Sukumar; Bhowmick, Suman; Goswami, Nupur; Sinha, Soumya Kumar; Maiti, Debabrata published their research in Nature Communications in 2021. The article was titled 《Imine as a linchpin approach for meta-C-H functionalization》.Reference of 5-Bromo-2-chloropyridine The article contains the following contents:

An temporary directing group (TDG) for meta-C-H functionalization via reversible imine formation were reported. By overruling facile ortho-C-H bond activation by imine-N atom, a suitably designed pyrimidine-based TDG successfully delivered selective meta-C-C bond formation. Application of this temporary directing group strategy for streamlining the synthesis of complex organic mols. without any necessary pre-functionalization at the meta position were explored.5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Konze, Kyle D.; Ma, Anqi; Li, Fengling; Barsyte-Lovejoy, Dalia; Parton, Trevor; MacNevin, Christopher J.; Liu, Feng; Gao, Cen; Huang, Xi-Ping; Kuznetsova, Ekaterina; Rougie, Marie; Jiang, Alice; Pattenden, Samantha G.; Norris, Jacqueline L.; James, Lindsey I.; Roth, Bryan L.; Brown, Peter J.; Frye, Stephen V.; Arrowsmith, Cheryl H.; Hahn, Klaus M.; Wang, Gang Greg; Vedadi, Masoud; Jin, Jian published 《An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1》.ACS Chemical Biology published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a transcriptionally repressive post-translational modification. Overexpression of EZH2 and hypertrimethylation of H3K27 have been implicated in a number of cancers. Several selective inhibitors of EZH2 have been reported recently. Herein we disclose UNC1999, the first orally bioavailable inhibitor that has high in vitro potency for wild-type and mutant EZH2 as well as EZH1, a closely related H3K27 methyltransferase that shares 96% sequence identity with EZH2 in their resp. catalytic domains. UNC1999 was highly selective for EZH2 and EZH1 over a broad range of epigenetic and non-epigenetic targets, competitive with the cofactor SAM and non-competitive with the peptide substrate. This inhibitor potently reduced H3K27me3 levels in cells and selectively killed diffused large B cell lymphoma cell lines harboring the EZH2Y641N mutant. Importantly, UNC1999 was orally bioavailable in mice, making this inhibitor a valuable tool for investigating the role of EZH2 and EZH1 in chronic animal studies. We also designed and synthesized UNC2400, a close analog of UNC1999 with potency >1,000-fold lower than that of UNC1999 as a neg. control for cell-based studies. Finally, we created a biotin-tagged UNC1999 (UNC2399), which enriched EZH2 in pull-down studies, and a UNC1999-dye conjugate (UNC2239) for co-localization studies with EZH2 in live cells. Taken together, these compounds represent a set of useful tools for the biomedical community to investigate the role of EZH2 and EZH1 in health and disease. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Category: pyridine-derivatives)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A visible-light-photocatalytic water-splitting strategy for sustainable hydrogenation/deuteration of aryl chlorides》 was published in Science China: Chemistry in 2020. These research results belong to Ling, Xiang; Xu, Yangsen; Wu, Shaoping; Liu, Mofan; Yang, Peng; Qiu, Chuntian; Zhang, Guoqiang; Zhou, Hongwei; Su, Chenliang. Application In Synthesis of 5-Bromo-2-chloropyridine The article mentions the following:

Abstract: Hydrogenation/deuteration of carbon chloride (C-Cl) bonds is of high significance but remains a remarkable challenge in synthetic chem., especially using safe and inexpensive hydrogen donors. In this article, a visible-light-photocatalytic water splitting hydrogenation technol. (WSHT) is proposed to in-situ generate active H-species (i.e., Had) for controllable hydrogenation of aryl chlorides instead of using flammable H2. When applying heavy water-splitting systems, we could selectively install deuterium at the C-Cl position of aryl chlorides under mild conditions for the sustainable synthesis of high-valued added deuterated chems. Sub-micrometer Pd nanosheets (Pd NSs) decorated crystallined polymeric carbon nitrides (CPCN) is developed as the bifunctional photocatalyst, whereas Pd NSs not only serve as a cocatalyst of CPCN to generate and stabilize H (D)-species but also play a significant role in the sequential activation and hydrogenation/deuteration of C-Cl bonds. This article highlights a photocatalytic-WSHT for controllable hydrogenation/deuteration of low-cost aryl chlorides, providing a promising way for the photosynthesis of high-valued added chems. instead of the hydrogen evolution. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Application In Synthesis of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application In Synthesis of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Devi, Namita; Hazarika, Sukanya; Gogoi, Prasanta; Barman, Pranjit published 《A novel dual-nano assisted synthesis of symmetrical disulfides from aryl/alkyl halides》.Synthetic Communications published the findings.Safety of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A novel approach towards dual-nano assisted synthesis of disulfides from coupling of alkyl/aryl halides and sulfur nanoparticles has been reported. The indium oxide nanoparticles as catalyst expedite the conversion and sulfur nanoparticles notably enhances the miscibility, providing a faster, high yielding and cost-effective process in an ethanol-water system. The method has synthetic advantages in terms of mild reaction framework, catalyst regeneration, and absence of any sulfide or polysulfide linkage as byproduct leading to a column free synthesis. A variety of alkyl, aryl and heteroaryl sym. disulfides are obtained in good to excellent yields up to 98%.5-Bromo-2-chloropyridine(cas: 53939-30-3Safety of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Buysse, Ann M.; Nugent, Benjamin M.; Wang, Nick X.; Benko, Zoltan; Breaux, Nneka; Rogers, Richard; Zhu, Yuanming published 《Studies toward understanding the SAR around the sulfoximine moiety of the sap-feeding insecticide sulfoxaflor》.Pest Management Science published the findings.Name: 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

BACKGROUND : The discovery of sulfoxaflor (IsoclastTM active) stemmed from a novel scaffold-based approach toward identifying bioactive mols. It exhibits broad-spectrum control of many sap-feeding insect pests, including aphids, whiteflies, hoppers and Lygus. Systematic modifications of the substituents flanking each side of the sulfoximine moiety were carried out to determine whether these changes would improve potency. Structure-activity relationship (SAR) studies showed that, with respect to the methylene linker, both mono- and disubstitution with alkyl groups of varying sizes as well as cyclic analogs exhibited excellent control of cotton aphids. However, against green peach aphids a decrease in activity was observed with substituents larger than Et as well as larger cycloalkyl groups. At the terminal tail there appeared to be a narrow steric tolerance as well, with linear groups or small rings more active against green peach aphids than bulkier groups. A novel series of compounds exploring the substituents flanking the sulfoximine moiety of sulfoxaflor were prepared and tested for bioactivity against cotton aphids and green peach aphids. SAR studies indicated that a decrease in green peach aphid potency was observed at the methylene linker as well as at the terminal tail with bulkier substituents. A quant.structure-activity relationship anal. of the compounds revealed significant correlation of activity with two mol. descriptors, vol (volumeof a mol.) and GCUT_SMR_3 (molar refractivity). This predictive model helps to explain the observed activity with the various substituents. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem