Category: 53939-30-3

In 2013,Zhang, Xiaoyan; Zhang, Nanjing; Chen, Guangming; Turpoff, Anthony; Ren, Hongyu; Takasugi, James; Morrill, Christie; Zhu, Jin; Li, Chunshi; Lennox, William; Paget, Steven; Liu, Yalei; Almstead, Neil; George Njoroge, F.; Gu, Zhengxian; Komatsu, Takashi; Clausen, Valerie; Espiritu, Christine; Graci, Jason; Colacino, Joseph; Lahser, Fred; Risher, Nicole; Weetall, Marla; Nomeir, Amin; Karp, Gary M. published 《Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A novel series of 6-(indol-2-yl)pyridine-3-sulfonamides I [R1 = CHF2O, c-Pr; R2 = i-Pr, H, CH(CH2F)2, etc.] was prepared and evaluated for their ability to inhibit HCV RNA replication in the HCV replicon cell culture assay. Preliminary optimization of this series furnished compounds with low nanomolar potency against the HCV genotype 1b replicon. Among these, compound I [R1 = CHF2O; R2 = CH(CH2F)2] was identified as a potent HCV replicon inhibitor (EC50 = 4 nM) with a selectivity index with respect to cellular GAPDH of more than 2500. Further, compound I [R1 = CHF2O; R2 = CH(CH2F)2] had a good pharmacokinetic profile in rats with an IV half-life of 6 h and oral bioavailability (F) of 62%. Selection of HCV replicon resistance identified an amino acid substitution in HCV NS4B that confers resistance to these compounds These compounds hold promise as a new chemotype with anti-HCV activity mediated through an underexploited viral target. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2015,Mane, Madhav S.; Gavade, Sandeep; Mane, Dhananjay V. published 《Designing and synthesis of N-(6-phenylpyridin-2-yl) pyridine-2-amine derivatives as a novel antimicrobial agent》.Journal of Environmental Nanotechnology published the findings.Recommanded Product: 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

A new series of N-(-6-phenylpyridin-2-yl) pyridine-2-amine derivatives were synthesized in satisfactory yield, through simple and greener methodol. using 2-Amino, 6-Chloro, Pyridines as a starting material. Some of the newly prepared compounds demonstrate potent inhibitory activity against Gram pos. bacteria, Gram neg. bacteria and fungai. The results are discussed in terms of structure-activity relationships and an attempt was made to define the structural features required for activity. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Kanishchev, Oleksandr S.; Dolbier, William R. Jr. published 《Ni/Ir-Catalyzed Photoredox Decarboxylative Coupling of S-Substituted Thiolactic Acids with Heteroaryl Bromides: Short Synthesis of Sulfoxaflor and Its SF5 Analog》.Chemistry – A European Journal published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

The Ni/Ir-catalyzed photoredox decarboxylative coupling of readily available S-substituted thiolactic acids such as S-Me thiolactic acid, S-Ph thiolactic acid, 2-(phenylsulfonyl)propanoic acid, etc. with electron-deficient heteroaryl bromides XBr (X = pyrimidin-2-yl, 5-cyanopyridin-2-yl, 4-F3CC6H4, etc.), resulted in the formation of simple but otherwise not easily accessible heteroarenes with alkylsulfide side chains XCH(CH3)SY (Y = Me, Ph). To demonstrate a practical use of this coupling reaction, its efficiency in the one-step synthesis of a key intermediate is shown in the synthesis of the recently marketed insecticide Sulfoxaflor, and for the short synthesis of SF5-Sulfoxaflor. The experimental process involved the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Smith, Kevin B.; Huang, Yuan; Brown, M. Kevin published 《Copper-Catalyzed Heteroarylboration of 1,3-Dienes with 3-Bromopyridines: A cine Substitution》.Angewandte Chemie, International Edition published the findings.Electric Literature of C5H3BrClN The information in the text is summarized as follows:

A method for the heteroarylboration of 1,3-dienes is presented. The process involves an unusual cine substitution of 3-bromopyridine derivatives to deliver highly functionalized heterocyclic products. Mechanistic studies are included that clarify the details of this unusual process. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-2-chloropyridine(cas: 53939-30-3Electric Literature of C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Electric Literature of C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5-Bromo-2-chloropyridineIn 2013 ,《Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Venier, Olivier; Pascal, Cecile; Braun, Alain; Namane, Claudie; Mougenot, Patrick; Crespin, Olivier; Pacquet, Francois; Mougenot, Cecile; Monseau, Catherine; Onofri, Benedicte; Dadji-Faihun, Rommel; Leger, Celine; Ben-Hassine, Majdi; Van-Pham, Thao; Ragot, Jean-Luc; Philippo, Christophe; Farjot, Geraldine; Noah, Lionel; Maniani, Karima; Boutarfa, Asma; Nicolai, Eric; Guillot, Etienne; Pruniaux, Marie-Pierre; Gussregen, Stefan; Engel, Christian; Coutant, Anne-Laure; de Miguel, Beatriz; Castro, Antonio. The article contains the following contents:

Starting from 11β-HSD1 inhibitors that were active ex vivo but with Cyp 3A4 liability, we obtained a new series of adamantane ureas displaying potent inhibition of both human and rodent 11β-HSD1 enzymes, devoid of Cyp 3A4 interactions, and rationally designed to provide long-lasting inhibition in target tissues. Final optimizations lead to SAR184841 with good oral pharmacokinetic properties showing in vivo activity and improvement of metabolic parameters in a physiopathol. model of type 2 diabetes. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Puttreddy, Rakesh; von Essen, Carolina; Rissanen, Kari published 《Halogen Bonds in Square Planar 2,5-Dihalopyridine-Copper(II) Bromide Complexes》.European Journal of Inorganic Chemistry published the findings.Recommanded Product: 53939-30-3 The information in the text is summarized as follows:

Halogen bonding in self-complementary 1:2 metal-ligand complexes obtained from copper(II) bromide (CuBr2) and seven 2,5-dihalopyridines were analyzed using single-crystal x-ray diffraction. All presented discrete complexes form 1D polymeric chains connected with C-X···Br-Cu halogen bonds (XB). In (2-chloro-5-X-pyridine)2·CuBr2 (X = Cl, Br, and I) only the C5-halogen and in (2-bromo-5-X-pyridine)2·CuBr2 (X = Cl, Br, and I) both C2- and C5-halogens form C-X···Br-Cu halogen bonds with the X acting as the XB donor and copper-coordinated bromide as the XB acceptor. The electron-withdrawing C2-chloride in (2-chloro-5-X-pyridine)2·CuBr2 complexes has only a minor effect on the C5-X5···Br-Cu XBs, and the X5···Br distances follow the expected order I5 < Br5 < Cl5 with RXB values of 0.91, 0.94, and 0.99, resp. In (2-bromo-5-X-pyridine)2·CuBr2 complexes, due to the polarization of both halogens, the C2-X2···Br-Cu and C5-X5···Br-Cu RXB values are very similar [0.92-0.99] as a result of the competition between C2- and C5-halogens for XB formation. In addition to the classical halogen bonds, the square-planar CuII complexes exhibit C2-X2···Cu(X = Cl and Br) contacts perpendicular to the Br-Cu-Br plane with shorter C2-Br2···Cu than C2-Cl2···Cu contacts. These interactions induce a pseudo-octahedral geometry for CuII ions. Notably, C2-X2···Br-Cu halogen bonds and the addnl. C2-X2···Cu contacts are slightly enhanced by the C5-halogen electronegativity. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of the American Chemical Society included an article by Lundrigan, Travis; Welsh, Erin N.; Hynes, Toren; Tien, Chieh-Hung; Adams, Matt R.; Roy, Kayelani R.; Robertson, Katherine N.; Speed, Alexander W. H.. SDS of cas: 53939-30-3. The article was titled 《Enantioselective Imine Reduction Catalyzed by Phosphenium Ions》. The information in the text is summarized as follows:

The first use of phosphenium cations in asym. catalysis is reported. A diazaphosphenium triflate, prepared in two or three steps on a multigram scale from com. available materials, catalyzes the hydroboration or hydrosilylation of cyclic imines with enantiomeric ratios of up to 97:3. Catalyst loadings are as low as 0.2 mol %. Twenty-two aryl/heteroaryl pyrrolidines and piperidines were prepared using this method. Imines containing functional groups such as thiophenes or pyridyl rings that can challenge transition-metal catalysts were reduced employing these systems. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3SDS of cas: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Catalytic enantioselective pyridine N-oxidation》 were Hsieh, Sheng-Ying; Tang, Yu; Crotti, Simone; Stone, Elizabeth A.; Miller, Scott J.. And the article was published in Journal of the American Chemical Society in 2019. COA of Formula: C5H3BrClN The author mentioned the following in the article:

The catalytic, enantioselective N-oxidation of substituted pyridines is described. The approach is predicated on a biomol.-inspired catalytic cycle wherein high levels of asym. induction are provided by aspartic-acid-containing peptides as the aspartyl side chain shuttles between free acid and peracid forms. Desymmetrizations of bis(pyridine) substrates bearing a remote pro-stereogenic center substituted with a group capable of hydrogen bonding to the catalyst are demonstrated. Our approach presents a new entry into chiral pyridine frameworks in a heterocycle-rich mol. environment. Representative functionalizations of the enantioenriched pyridine N-oxides further document the utility of this approach. Demonstration of the asym. N-oxidation in two venerable drug-like scaffolds, Loratadine and Varenicline, show the likely generality of the method for highly variable and distinct chiral environments, while also revealing that the approach is applicable to both pyridines and 1,4-pyrazines. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Van Raden, Jeff M.; Louie, Shayan; Zakharov, Lev N.; Jasti, Ramesh published 《2,2′-Bipyridyl-Embedded Cycloparaphenylenes as a General Strategy To Investigate Nanohoop-Based Coordination Complexes》.Journal of the American Chemical Society published the findings.SDS of cas: 53939-30-3 The information in the text is summarized as follows:

Because of their unique cyclic architectures, tunable electronic properties, and supramol. chemistries, cycloparaphenylenes (CPPs) have the potential to act as a new class of ligands for coordination cages, metal-organic frameworks, and small-mol. transition-metal complexes. However, currently there is no general strategy to coordinate the cyclic framework to a variety of metal centers. The authors report here a general and scalable synthetic strategy to embed 2,2′-bipyridine units into the backbone of CPPs. The authors use this approach to synthesize a 2,2′-bipyridine-embedded [8]CPP (L), which the authors show can successfully coordinate to both Pd(II) and Ru(II) forming [PdLCl2], [PdL2](BF4)2 and [Ru(L)(bipy)2](PF6)2. The resulting coordination complexes, a Pd(II) nanohoop dimer and a bis(bipyridyl)ruthenium(II) functionalized nanohoop, show unique solid-state and photophys. properties. This work provides a proof of concept for a general strategy to use nanohoops and their derivatives as a new class of ligands. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-2-chloropyridine(cas: 53939-30-3SDS of cas: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. SDS of cas: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 53939-30-3In 2014 ,《Continuous flow magnesiation of functionalized heterocycles and acrylates with TMPMgCl.LiCl》 appeared in Angewandte Chemie, International Edition. The author of the article were Petersen, Trine P.; Becker, Matthias R.; Knochel, Paul. The article conveys some information:

The metalation of functionalized heterocycles (pyridines, pyrimidines, thiophenes, and thiazoles) and various acrylates using the strong, non-nucleophilic base TMPMgCl.LiCl was carried out. The flow conditions allow the magnesiations to be performed under more convenient conditions than the comparable batch reactions, which often require cryogenic temperatures and long reaction times. Moreover, the flow reactions are directly scalable without further optimization. Metalation under flow conditions also allows magnesiations that did not produce the desired products under batch conditions, such as the magnesiation of sensitive acrylic derivatives The magnesiated species are subsequently quenched with various electrophiles, thereby introducing a broad range of functionalities. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem