Category: 54-47-7

Quality determination of avocado fruit immersed in pyridoxal 5′-phosphate solution was written by Vincent, Celia;Munne-Bosch, Sergi. And the article was included in Journal of Food Composition and Analysis in 2022.Related Products of 54-47-7 The following contents are mentioned in the article:

Vitamin B6 plays a crucial role in plant metabolism It acts as a cofactor in over 140 reactions and has a potent antioxidant function, as described in plant growth and development related to root and leaf tissues, but not yet in fruit ripening. Here, we aimed to explore simple practices to improve endogenous content of vitamin B6 in avocados, measured by high-performance liquid chromatog. (HPLC), and to evaluate to what extent and through which mechanisms pyridoxal-5′-phosphate (PLP) treatment influences fruit quality during postharvest ripening and cold storage. Emphasis was put on evaluating a possible link between vitamin B6 and phytohormones by performing hormonal profiling analyses using ultra-high performance liquid chromatog. coupled to tandem mass spectrometry (UHPLC-MS/MS). We hypothesized that PLP could improve quality parameters and prolong the shelf life of fruit. Results showed that Bacon avocados had a low vitamin B6 content compared to Hass and other varieties. However, basic techniques like short-term cold storage increased the vitamin B6 content 2.5 fold. Exogenous application of vitamin B6 slightly delayed avocado ripening at room temperature and caused reduced softening in the mesocarp, which was related to a hormonal response that was most likely mediated by cytokinins. In long-term cold-stored avocados, PLP treatment triggered γ-tocotrienol and plastochromanol-8 accumulation, which improved the tocochromanol composition in the fruit. In conclusion, the vitamin B6 content of Bacon avocados can be improved through simple practices. Exogenous applications of PLP can be used either to delay ripening of avocados at room temperatures or to increase tocochromanol content in cold-stored fruit. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Related Products of 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality determination of avocado fruit immersed in pyridoxal 5′-phosphate solution was written by Vincent, Celia;Munne-Bosch, Sergi. And the article was included in Journal of Food Composition and Analysis in 2022.Reference of 54-47-7 The following contents are mentioned in the article:

Vitamin B6 plays a crucial role in plant metabolism It acts as a cofactor in over 140 reactions and has a potent antioxidant function, as described in plant growth and development related to root and leaf tissues, but not yet in fruit ripening. Here, we aimed to explore simple practices to improve endogenous content of vitamin B6 in avocados, measured by high-performance liquid chromatog. (HPLC), and to evaluate to what extent and through which mechanisms pyridoxal-5′-phosphate (PLP) treatment influences fruit quality during postharvest ripening and cold storage. Emphasis was put on evaluating a possible link between vitamin B6 and phytohormones by performing hormonal profiling analyses using ultra-high performance liquid chromatog. coupled to tandem mass spectrometry (UHPLC-MS/MS). We hypothesized that PLP could improve quality parameters and prolong the shelf life of fruit. Results showed that Bacon avocados had a low vitamin B6 content compared to Hass and other varieties. However, basic techniques like short-term cold storage increased the vitamin B6 content 2.5 fold. Exogenous application of vitamin B6 slightly delayed avocado ripening at room temperature and caused reduced softening in the mesocarp, which was related to a hormonal response that was most likely mediated by cytokinins. In long-term cold-stored avocados, PLP treatment triggered γ-tocotrienol and plastochromanol-8 accumulation, which improved the tocochromanol composition in the fruit. In conclusion, the vitamin B6 content of Bacon avocados can be improved through simple practices. Exogenous applications of PLP can be used either to delay ripening of avocados at room temperatures or to increase tocochromanol content in cold-stored fruit. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Reference of 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Reference of 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Plateau zokors (Eospalax baileyi) respond to secondary metabolites from the roots of Stellera chamaejasme by enhancing hepatic inflammatory factors and metabolic pathway genes was written by Tan, Yuchen;Liu, Qianqian;Wang, Zhicheng;Pu, Qiangsheng;Shi, Shangli;Su, Junhu. And the article was included in Comparative Biochemistry and Physiology in 2022.SDS of cas: 54-47-7 The following contents are mentioned in the article:

Herbivores rarely consume toxic plants. An increase in the proportion of toxic plant secondary metabolites (PSMs) in poisonous plants can promote detoxification and related metabolic capacity of animals. Poisonous plants with thick taproots like Stellera chamaejasme (SC) are important stored food for the plateau zokor (Eospalax baileyi) during the winter and promote the development of detoxification mechanisms in this animal. In this study, plateau zokors were administered gavages of 0.2, 1.05, and 2.10 mL/kg SC water extracts Serum samples were collected from plateau zokors to measure the levels of transaminases and oxidative stress. Transcriptome anal. was conducted to evaluate the differential genes of multiple metabolic pathways to investigate the relationship between the physiol. processes and metabolic adaptation capacity of these animals in response to SC. After SC administration, plateau zokors showed significant hepatic granular degeneration and inflammatory reactions in the liver and aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels increased in a dose-dependent manner. Further, differential expression was also found in the plateau zokor livers, with most enrichment in inflammation and detoxification metabolism pathways. The metabolic adaptation responses in P 450 xenobiotic clearance, bile secretion, and pancreatic secretion (Gusb, Hmgcr, Gstm1, Gstp1, and Eobag004630005095) were verified by mRNA network anal. as key factors related to the mechanism. Plateau zokors respond to SC PSMs through changes in liver physiol., biochem., and genes in multiple metabolic pathways, validating our hypothesis that plateau zokors can metabolize PSMs when they ingest toxic plants. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7SDS of cas: 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Plateau zokors (Eospalax baileyi) respond to secondary metabolites from the roots of Stellera chamaejasme by enhancing hepatic inflammatory factors and metabolic pathway genes was written by Tan, Yuchen;Liu, Qianqian;Wang, Zhicheng;Pu, Qiangsheng;Shi, Shangli;Su, Junhu. And the article was included in Comparative Biochemistry and Physiology in 2022.Product Details of 54-47-7 The following contents are mentioned in the article:

Herbivores rarely consume toxic plants. An increase in the proportion of toxic plant secondary metabolites (PSMs) in poisonous plants can promote detoxification and related metabolic capacity of animals. Poisonous plants with thick taproots like Stellera chamaejasme (SC) are important stored food for the plateau zokor (Eospalax baileyi) during the winter and promote the development of detoxification mechanisms in this animal. In this study, plateau zokors were administered gavages of 0.2, 1.05, and 2.10 mL/kg SC water extracts Serum samples were collected from plateau zokors to measure the levels of transaminases and oxidative stress. Transcriptome anal. was conducted to evaluate the differential genes of multiple metabolic pathways to investigate the relationship between the physiol. processes and metabolic adaptation capacity of these animals in response to SC. After SC administration, plateau zokors showed significant hepatic granular degeneration and inflammatory reactions in the liver and aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels increased in a dose-dependent manner. Further, differential expression was also found in the plateau zokor livers, with most enrichment in inflammation and detoxification metabolism pathways. The metabolic adaptation responses in P 450 xenobiotic clearance, bile secretion, and pancreatic secretion (Gusb, Hmgcr, Gstm1, Gstp1, and Eobag004630005095) were verified by mRNA network anal. as key factors related to the mechanism. Plateau zokors respond to SC PSMs through changes in liver physiol., biochem., and genes in multiple metabolic pathways, validating our hypothesis that plateau zokors can metabolize PSMs when they ingest toxic plants. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Product Details of 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Characterization and application of L-methionine γ-lyase Q349S mutant enzyme with an enhanced activity toward L-homocysteine was written by Okawa, Atsushi;Handa, Haruhisa;Yasuda, Eri;Murota, Masaki;Kudo, Daizo;Tamura, Takashi;Shiba, Tomoo;Inagaki, Kenji. And the article was included in Journal of Bioscience and Bioengineering in 2022.Quality Control of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate The following contents are mentioned in the article:

L-Methionine γ-lyse (MGL), a pyridoxal 5′-phosphate-dependent enzyme, catalyzes the α,γ-elimination of L-methionine (L-Met) and L-homocysteine (L-Hcy) to produce α-keto acids, thiols, and ammonia. Previously, various mutant enzymes of Pseudomonas putida MGL (PpMGL) were prepared to identify a homocysteine (Hcy)-specific enzyme that would assist the diagnosis of homocystinuria. Among the mutat enzymes the Q349S mutant exhibited high degradation activity toward L-Hcy. In the present study, PpMGL Q349S was characterized; the results suggested that it could be applied to determine the amount of L-Hcy. Compared to the wild-type PpMGL, specific activities of the Q349S mutant with L-Hcy and L-Met were 1.5 and 0.7 times, resp. Addnl., we confirmed that L-Hcy in plasma samples could be accurately detected using the Q349S mutant by preincubating it with cysteine desulfurase (CsdA). Furthermore, we determined the X-ray crystal structure of PpMGL Q349S L-Met or L-Hcy complexes Michaelis complex, germinal diamine, and external aldimine at 2.25-2.40 Å. These 3D structures showed that the interaction partner of the β-hydroxyl group of Thr355 in the wild-type PpMGL was changed to the carboxyl group of the Hcy-PLP external aldimine in the Q349S mutant. The interaction of Ser349 and Arg375 was different between L-Met and L-Hcy recognition, indicating that it was important for the recognition of the carboxyl group of the substrate. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Quality Control of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Characterization and application of L-methionine γ-lyase Q349S mutant enzyme with an enhanced activity toward L-homocysteine was written by Okawa, Atsushi;Handa, Haruhisa;Yasuda, Eri;Murota, Masaki;Kudo, Daizo;Tamura, Takashi;Shiba, Tomoo;Inagaki, Kenji. And the article was included in Journal of Bioscience and Bioengineering in 2022.Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate The following contents are mentioned in the article:

L-Methionine γ-lyse (MGL), a pyridoxal 5′-phosphate-dependent enzyme, catalyzes the α,γ-elimination of L-methionine (L-Met) and L-homocysteine (L-Hcy) to produce α-keto acids, thiols, and ammonia. Previously, various mutant enzymes of Pseudomonas putida MGL (PpMGL) were prepared to identify a homocysteine (Hcy)-specific enzyme that would assist the diagnosis of homocystinuria. Among the mutat enzymes the Q349S mutant exhibited high degradation activity toward L-Hcy. In the present study, PpMGL Q349S was characterized; the results suggested that it could be applied to determine the amount of L-Hcy. Compared to the wild-type PpMGL, specific activities of the Q349S mutant with L-Hcy and L-Met were 1.5 and 0.7 times, resp. Addnl., we confirmed that L-Hcy in plasma samples could be accurately detected using the Q349S mutant by preincubating it with cysteine desulfurase (CsdA). Furthermore, we determined the X-ray crystal structure of PpMGL Q349S L-Met or L-Hcy complexes Michaelis complex, germinal diamine, and external aldimine at 2.25-2.40 Å. These 3D structures showed that the interaction partner of the β-hydroxyl group of Thr355 in the wild-type PpMGL was changed to the carboxyl group of the Hcy-PLP external aldimine in the Q349S mutant. The interaction of Ser349 and Arg375 was different between L-Met and L-Hcy recognition, indicating that it was important for the recognition of the carboxyl group of the substrate. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition ( EPIC ) study was written by Clasen, Joanna L.;Heath, Alicia K.;Van Puyvelde, Heleen;Huybrechts, Inge;Park, Jin Young;Ferrari, Pietro;Scelo, Ghislaine;Ulvik, Arve;Midttun, oeivind;Ueland, Per Magne;Overvad, Kim;Eriksen, Anne Kirstine;Tjoenneland, Anne;Kaaks, Rudolf;Katzke, Verena;Schulze, Matthias B.;Palli, Domenico;Agnoli, Claudia;Chiodini, Paolo;Tumino, Rosario;Sacerdote, Carlotta;Zamora-Ros, Raul;Rodriguez-Barranco, Miguel;Santiuste, Carmen;Ardanaz, Eva;Amiano, Pilar;Schmidt, Julie A.;Weiderpass, Elisabete;Gunter, Marc;Riboli, Elio;Cross, Amanda J.;Johansson, Mattias;Muller, David C.. And the article was included in International Journal of Cancer in 2022.Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate The following contents are mentioned in the article:

Previous studies have suggested that components of one-carbon metabolism, particularly circulating vitamin B6, have an etiol. role in renal cell carcinoma (RCC). Vitamin B6 is a cofactor in the transsulfuration pathway. We sought to holistically investigate the role of the transsulfuration pathway in RCC risk. We conducted a nested case-control study (455 RCC cases and 455 matched controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Plasma samples from the baseline visit were analyzed for metabolites of the transsulfuration pathway, including pyridoxal 5′-phosphate (PLP, the biol. active form of vitamin B6), homocysteine, serine, cystathionine, and cysteine, in addition to folate. Bayesian conditional logistic regression was used to estimate associations of metabolites with RCC risk as well as interactions with established RCC risk factors. Circulating PLP and cysteine were inversely associated with RCC risk, and these associations were not attenuated after adjustment for other transsulfuration metabolites (odds ratio (OR) and 90% credible interval (CrI) per 1 SD increase in log concentration: 0.76 [0.66, 0.87]; 0.81 [0.66, 0.96], resp.). A comparison of joint metabolite profiles suggested substantially greater RCC risk for the profile representative of low overall transsulfuration function compared to high function (OR 2.70 [90% CrI 1.26, 5.70]). We found some statistical evidence of interactions of cysteine with body mass index, and PLP and homocysteine with smoking status, on their associations with RCC risk. In conclusion, we found evidence suggesting that the transsulfuration pathway may play a role in metabolic dysregulation leading to RCC development. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study was written by Clasen, Joanna L.;Heath, Alicia K.;Van Puyvelde, Heleen;Huybrechts, Inge;Park, Jin Young;Ferrari, Pietro;Scelo, Ghislaine;Ulvik, Arve;Midttun, oeivind;Ueland, Per Magne;Overvad, Kim;Eriksen, Anne Kirstine;Tjoenneland, Anne;Kaaks, Rudolf;Katzke, Verena;Schulze, Matthias B.;Palli, Domenico;Agnoli, Claudia;Chiodini, Paolo;Tumino, Rosario;Sacerdote, Carlotta;Zamora-Ros, Raul;Rodriguez-Barranco, Miguel;Santiuste, Carmen;Ardanaz, Eva;Amiano, Pilar;Schmidt, Julie A.;Weiderpass, Elisabete;Gunter, Marc;Riboli, Elio;Cross, Amanda J.;Johansson, Mattias;Muller, David C.. And the article was included in International Journal of Cancer in 2022.Related Products of 54-47-7 The following contents are mentioned in the article:

Previous studies have suggested that components of one-carbon metabolism, particularly circulating vitamin B6, have an etiol. role in renal cell carcinoma (RCC). Vitamin B6 is a cofactor in the transsulfuration pathway. We sought to holistically investigate the role of the transsulfuration pathway in RCC risk. We conducted a nested case-control study (455 RCC cases and 455 matched controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Plasma samples from the baseline visit were analyzed for metabolites of the transsulfuration pathway, including pyridoxal 5′-phosphate (PLP, the biol. active form of vitamin B6), homocysteine, serine, cystathionine, and cysteine, in addition to folate. Bayesian conditional logistic regression was used to estimate associations of metabolites with RCC risk as well as interactions with established RCC risk factors. Circulating PLP and cysteine were inversely associated with RCC risk, and these associations were not attenuated after adjustment for other transsulfuration metabolites (odds ratio (OR) and 90% credible interval (CrI) per 1 SD increase in log concentration: 0.76 [0.66, 0.87]; 0.81 [0.66, 0.96], resp.). A comparison of joint metabolite profiles suggested substantially greater RCC risk for the profile representative of low overall transsulfuration function compared to high function (OR 2.70 [90% CrI 1.26, 5.70]). We found some statistical evidence of interactions of cysteine with body mass index, and PLP and homocysteine with smoking status, on their associations with RCC risk. In conclusion, we found evidence suggesting that the transsulfuration pathway may play a role in metabolic dysregulation leading to RCC development. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Related Products of 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS-1211, a tissue-nonspecific alkaline phosphatase inhibitor was written by Maruyama, Sonomi;Visser, Hester;Ito, Takashi;Limsakun, Tharin;Zahir, Hamim;Ford, Daniel;Tao, Ben;Zamora, Cynthia A.;Stark, Jeffrey G.;Chou, Hubert S.. And the article was included in Clinical and Translational Science in 2022.Application of 54-47-7 The following contents are mentioned in the article:

Tissue-nonspecific alk. phosphatase (TNAP) hydrolyzes and inactivates inorganic pyrophosphate (PPi), a potent inhibitor of calcification; therefore, TNAP inhibition is a potential target to treat ectopic calcification. These two first-in-human studies evaluated safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of single (SAD) and multiple-ascending doses (MAD) of DS-1211, a TNAP inhibitor. Healthy adults were randomized 6:2 to DS-1211 or placebo, eight subjects per dose cohort. SAD study subjects received one dose of DS-1211 (range, 3-3000 mg) or placebo, whereas MAD study subjects received DS-1211 (range, 10-300 mg) once daily, 150 mg twice daily (b.i.d.), or placebo for 10 days. Primary end points were safety and tolerability. PK and PD assessments included plasma concentrations of DS-1211, alk. phosphatase (ALP) activity, and TNAP substrates (PPi, pyridoxal 5′-phosphate [PLP], and phosphoethanolamine [PEA]). A total of 56 (DS-1211: n = 42; placebo: n = 14) and 40 (DS-1211: n = 30; placebo: n = 10) subjects enrolled in the SAD and MAD studies, resp. In both studies, adverse events were mild or moderate and did not increase with dose. PKs of DS-1211 were linear up to 100 mg administered as a single dose and 150 mg b.i.d. administered as a multiple-dose regimen. In multiple dosing, there was minimal accumulation of DS-1211. Increased DS-1211 exposure correlated with dose-dependent ALP inhibition and concomitant increases in PPi, PLP, and PEA. In two phase I studies, DS-1211 appeared safe and well-tolerated. Post-treatment PD assessments were consistent with exposure-dependent TNAP inhibition. These data support further evaluation of DS-1211 for ectopic calcification diseases. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Application of 54-47-7).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 54-47-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS-1211, a tissue-nonspecific alkaline phosphatase inhibitor was written by Maruyama, Sonomi;Visser, Hester;Ito, Takashi;Limsakun, Tharin;Zahir, Hamim;Ford, Daniel;Tao, Ben;Zamora, Cynthia A.;Stark, Jeffrey G.;Chou, Hubert S.. And the article was included in Clinical and Translational Science in 2022.Electric Literature of C8H10NO6P The following contents are mentioned in the article:

Tissue-nonspecific alk. phosphatase (TNAP) hydrolyzes and inactivates inorganic pyrophosphate (PPi), a potent inhibitor of calcification; therefore, TNAP inhibition is a potential target to treat ectopic calcification. These two first-in-human studies evaluated safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of single (SAD) and multiple-ascending doses (MAD) of DS-1211, a TNAP inhibitor. Healthy adults were randomized 6:2 to DS-1211 or placebo, eight subjects per dose cohort. SAD study subjects received one dose of DS-1211 (range, 3-3000 mg) or placebo, whereas MAD study subjects received DS-1211 (range, 10-300 mg) once daily, 150 mg twice daily (b.i.d.), or placebo for 10 days. Primary end points were safety and tolerability. PK and PD assessments included plasma concentrations of DS-1211, alk. phosphatase (ALP) activity, and TNAP substrates (PPi, pyridoxal 5′-phosphate [PLP], and phosphoethanolamine [PEA]). A total of 56 (DS-1211: n = 42; placebo: n = 14) and 40 (DS-1211: n = 30; placebo: n = 10) subjects enrolled in the SAD and MAD studies, resp. In both studies, adverse events were mild or moderate and did not increase with dose. PKs of DS-1211 were linear up to 100 mg administered as a single dose and 150 mg b.i.d. administered as a multiple-dose regimen. In multiple dosing, there was minimal accumulation of DS-1211. Increased DS-1211 exposure correlated with dose-dependent ALP inhibition and concomitant increases in PPi, PLP, and PEA. In two phase I studies, DS-1211 appeared safe and well-tolerated. Post-treatment PD assessments were consistent with exposure-dependent TNAP inhibition. These data support further evaluation of DS-1211 for ectopic calcification diseases. This study involved multiple reactions and reactants, such as (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7Electric Literature of C8H10NO6P).

(4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate (cas: 54-47-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C8H10NO6P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem