Category: 5407-87-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5407-87-4, name is 2-Amino-4,6-dimethylpyridine. A new synthetic method of this compound is introduced below., name: 2-Amino-4,6-dimethylpyridine

to a 100 mL 3 -necked round-bottom flask was placed 4,6-dimethylpyridin-2-amine (1.0 equiv, 19.6 mmol, 2.4 g) and DCM (20 mL). The reaction system was cooled down to -50 C in a liquid nitrogen bath, and l,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (1.0 equiv, 19.6 mmol, 5.6 g) was added. The resulting solution was stirred at -50 C for 30 min and gradually warmed to 25 C in 30 min. The reaction mixture was quenched with saturated NaHCO, (20 mL) and extracted withdichloromethane (2 x 20 mL). The organic layers were combined and concentrated under vacuum to afford 3.2 g (81.0%) of 5-bromo-4,6-dimethylpyridin-2-amine as an off-white solid. (M+H)+= 200.8, 202.8

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Reference:
Patent; CRINETICS PHARMACEUTICALS, INC.; ZHAO, Jian; WANG, Shimiao; ZHU, Yunfei; (212 pag.)WO2019/157458; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5407-87-4, name is 2-Amino-4,6-dimethylpyridine, molecular formula is C7H10N2, molecular weight is 122.17, as common compound, the synthetic route is as follows.5407-87-4

The mixture of 4,6-dimethylpyridin-2-amine (1 g, 8.2 mmol, 1.0 eq) and NBS (1.46 g, 8.2 mmol, 1.0 eq) in CH3CN (30 mL) was stirred at rt overnight. Then the mixture was concentrated, and the residue was purified on silica gel column (PE/EtOAc = 5/1) to afford 5-bromo-4,6-dimethylpyridin-2-amine as a yellow solid (800 mg, 48%).

Statistics shows that 5407-87-4 is playing an increasingly important role. we look forward to future research findings about 2-Amino-4,6-dimethylpyridine.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5407-87-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5407-87-4, name is 2-Amino-4,6-dimethylpyridine, molecular formula is C7H10N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 22. To a mixture of 1,3,5-tris(bromomethyl)-2,4,6-trimethyl-benzene (1b) (3.00 g, 6.80 mmol) and K2CO3 (1.88 g, 13.60 mmol) in CH3CN/THF (1:1 v/v; 40 mL) was added dropwise a CH3CN (10 mL) solution of 2-amino-4,6-dimethyl-pyridine (1.66 g, 13.60 mmol).The mixture was stirred at room temperature for 72 h. After filtration and evaporation of solvents, the crude product was purified by column chromatography (ethyl acetate/toluene, 1:3 v/v). Yield 30 %. M.p. 77-78 C. 1H-NMR (400 MHz, CDCl3) delta = 1.22 (t, 3H, J = 7.5 Hz), 1.29 (t, 6H, J = 7.5 Hz), 2.24 (s, 6H), 2.36 (s, 6 H), 2.73 (q, 2H, J = 7.5 Hz), 2.85 (q, 4H, J = 7.5 Hz), 4.23 (t, 2H, J = 4.2 Hz), 4.37 (d, 4H, J = 4.2 Hz), 4.62 (s, 2 H), 6.10 (s, 2 H), 6.35 (s, 2 H). 13C-NMR (100 MHz, CDCl3) delta = 16.4, 16.7, 21.1, 22.8, 23.0, 24.1, 29.6, 40.5, 103.6, 113.9, 131.9, 133.4, 143.8, 144.9, 148.9, 156.5, 158.0. HR-MS calcd for C29H39BrN4 5232.2353; found: 522.2360. Rf= 0.31 (ethyl acetate/toluene, 1:3 v/v).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5407-87-4, 2-Amino-4,6-dimethylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Technische Universitaet Carolo-Wilhelmina zu Braunschweig; EP1972627; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5407-87-4, name is 2-Amino-4,6-dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows. 5407-87-4

Step 1 Preparation of 2-amino-4,6-dimethyl-5-bromopyridine 20 g(0.164 mole) of 2-amino-4, 6-dimethylpyridine was added into a mixture of 69 ml of water and 16.1 g(0.164 mole) of sulfuric acid and the resulting solution was cooled to 0 C., and thereto was added 8.45 ml(0.164 mole) of bromine gradually at 0 C. The resulting solution was stirred for 30 minutes, adjusted to pH 9 to 10 with aqueous sodium hydroxide solution and extracted with dichloromethane. The organic layer was washed with water, dried over anhydrous Na2 SO4 and concentrated under reduced pressure. The residue was purified with silica gel column chromatography to obtain 18.25 g of the title compound(yield 55%) and 5.4 g of dibromo compound(yield 11.8%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5407-87-4, 2-Amino-4,6-dimethylpyridine.

Reference:
Patent; Korea Research Institute of Chemical Technology; US5849753; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem