Category: 54127-30-9

Electric Literature of 54127-30-9, Adding some certain compound to certain chemical reactions, such as: 54127-30-9, name is (5,6-Dichloropyridin-3-yl)methanol,molecular formula is C6H5Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 54127-30-9.

2,3-Dichloro-5-formylpyridine. To a 500 mL round-bottom flask, manganese oxide (43.5 g, 0.50 mol) was added to a solution of 2,3-dichloro-5-hydroxylmethylpyridine (64, 8.10 g, 50.0 mmol) in anhydrous CH2CIo ( 150 mL). The reaction mixture was stirred at a temperature of about 250C for 48 h, filtered through CELITE, and concentrated under reduced pressure. The mixture was chromatographed by a silica gel chromatography column eluting with a gradient of ethyl acetate (0%-40%)/hexanes to provide 7.2 g of 65 (90% yield). 1H NMR (400 MHz, CDCl3) delta 10.08 (IH, s), 8.77 (I H, d, J=1.97 Hz), 8.25 (IH, d, J=1.97 Hz). LC/MS (M+1 ): 176.

According to the analysis of related databases, 54127-30-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PURDUE PHARMA L.P.; SHIONOGI & CO., LTD.; WO2008/132600; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54127-30-9, name is (5,6-Dichloropyridin-3-yl)methanol. A new synthetic method of this compound is introduced below., Safety of (5,6-Dichloropyridin-3-yl)methanol

The intermediate, ethyl (E)-3-{2-[3′-(l-adamantyl)-4′-hydroxyphenyl]-3-chloro-5- pyridinyl}-2-propenoate was prepared as follows.; a) Ethyl (?)-3-(5,6-Dichloro-2-pyridinyl)-2-propenoate.; A reported method(Ognyanov, V. I. et al., J. Med. Chem., 2006, 49, 3719-3742) was used to synthesize 2,3- dichloro-5-formylpyridine. A mixture of 5,6-dichloro-3-pyridinemethanol (1.42 g, 8.00 mmol) and Mn02 (13.9 g, 160 mmol) in 1 : 1 CH2Cl2/hexane (8 mL) was stirred for 1 h, then diluted with 50% EtOAc/hexane (20 mL), and filtered (50% EtOAc/hexane wash). The filtrate was evaporated, and the residue was dried in vacuo for use in the next step.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 54127-30-9, (5,6-Dichloropyridin-3-yl)methanol.

Reference:
Patent; WAYNE STATE UNIVERSITY; SANDFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; FONTANA, Joseph, A.; DAWSON, Marcia; XIA, Zebin; WO2011/79305; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 54127-30-9 ,Some common heterocyclic compound, 54127-30-9, molecular formula is C6H5Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 500 mL round-bottom flask, manganese oxide (43.5 g, 0.50 mol) was added to a solution of 2,3-dichloro-5-hydroxymethylpyridine (3, 8.10 g, 50.0 mmol, Sigma-Aldrich, St. Louis, Mo.) in anhydrous CH2Cl2 (150 mL). The reaction mixture was stirred at a temperature of about 25 C. for 48 h, filtered through CELITE, and concentrated under reduced pressure. The mixture was chromatographed by a silica gel chromatography column eluting with a gradient of ethyl acetate (0%-40%)/hexanes to provide 7.2 g of 4 (90% yield). 1H NMR (400 MHz, CDCl3) delta 10.08 (1H, s), 8.77 (1H, d, J=1.97 Hz), 8.25 (1H, d, J=1.97 Hz). LC/MS (M+1): 176.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 54127-30-9, (5,6-Dichloropyridin-3-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tafesse, Laykea; US2010/120862; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem