Category: 54151-74-5

Cobalt(III)-Catalyzed Directed C-H Coupling with Diazo Compounds: Straightforward Access towards Extended 锜?Systems was written by Zhao, Dongbing;Kim, Ju Hyun;Stegemann, Linda;Strassert, Cristian A.;Glorius, Frank. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 54151-74-5 This article mentions the following:

The first highly efficient and scalable cobalt-catalyzed directed C-H functionalization with carbene precursors is presented. This methodol. provides a modular route towards a new class of conjugated polycyclic hydrocarbons with tunable emission wavelengths both in solution and in the solid state. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Recommanded Product: 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel diversely substituted 1-heteroaryl-2-imidazolines for fragment-based drug discovery was written by Krasavin, Mikhail. And the article was included in Tetrahedron Letters in 2012.Related Products of 54151-74-5 This article mentions the following:

A palladium-catalyzed Buchwald-Hartwig arylation protocol has been applied to achieve high-yielding N-heteroarylation of a diverse set of privileged 2-imidazolines, e.g. I. The resulting compounds are of interest as a novel type of mol. tool for fragment-based drug discovery. The potential for combining two 2-imidazoline moieties in a heteroarene-linked dimer via sequential Pd-catalyzed arylation has been demonstrated. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Related Products of 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Triarylbismuthanes as Threefold Aryl-Transfer Reagents in Regioselective Cross-Coupling Reactions with Bromopyridines and Quinolines was written by Rao, Maddali L. N.;Dhanorkar, Ritesh J.. And the article was included in European Journal of Organic Chemistry in 2014.COA of Formula: C11H8BrN This article mentions the following:

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalyzed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both sym. and unsym. diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalyzed conditions. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5COA of Formula: C11H8BrN).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C11H8BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation of some substituted 2,6-bis(2-pyridyl)pyridines was written by Case, Francis H.;Kasper, Thomas J.. And the article was included in Journal of the American Chemical Society in 1956.Recommanded Product: 2-Bromo-4-phenylpyridine This article mentions the following:

The appropriate 2- or 4-substituted pyridine (1 mole), 1.18 moles NaNH₂, and 2.2 moles PhNMe₂ heated 6 hrs. at 150-60° (130-40° with 4-ethylpyridine), cooled, and poured into H₂O, the organic layer dried, the PhNMe₂ distilled, and the residue distilled or recrystallized gave the corresponding substituted-2-aminopyridine (I) (substituent, % yield, and m.p. given): 4-Et, 53, 70-1° (from pert. ether); 4-Ph, 53, 164-5° (from C₆H₆); 6-Ph, 70, 71-2° (from petr. ether). The appropriate I (0.3 mole) in 175 cc. 48% HBr treated with 42 cc. Br, the mixture treated gradually with 52 g. NaNO₂ in 74 cc. H₂O below 5° and then with 112 g. NaOH in 285 cc. H₂O below 20°, and extracted with Et₂O, the extract evaporated, and the residue distilled in vacuo or recrystd, gave the corresponding substituted-2-bromopyridines (II) (substituent, % yield, and b.p./mm. or m.p. given): 4-Et, 88, 103-5°/11; 4-Ph, 63, 65-6° (from petr. ether); 6-Ph, 62, 51-2° (from petr. ether). The appropriate II (1 mole) and 1.1 moles CuCN heated gently with a smoky flame to beginning reaction, the mixture evacuated as quickly as possible to 5 mm. (40 mm. with the Me derivative), and the reaction product distilled rapidly gave the corresponding substituted-2-cyanopyridine (substituent, % yield, and m.p. given): 4-Me (III), 28, 88-9°; 4-Ph (IV), 60, 99-100°; 6-Ph (IVa), 67, 64-6°; 4-Et (V), 61, -(b₁₁ 123-4°). III (11.8 g.) in 125 cc. dry C₆H₆ and 100 cc. Et₂O treated with MeMgI from 35.5 g. MeI and 6 g. Mg in Et₂O, the mixture warmed to room temperature, stirred 1 hr., and decomposed with cold aqueous NH₄Cl, and the Et₂O layer worked up yielded 8.0 g. 2-acetyI-4-methylpyridine (VI), b₁₅ 95-7°, m. 33-4° (from petr. ether). V (13.2 g.) gave similarly 7.0 g. 4-Et homolog of VI. IVa (20 g.) refluxed 5 hrs. with 220 cc. saturated alc. HCl, cooled, filtered, concentrated in vacuo on the steam bath, cooled, poured into H₂O, and neutralized with NH₄OH precipitated 79% 2-carbethoxy-6-phenylpyridine (VII), colorless solid, m. 50-7°. IV (17.3 g.) yielded similarly 15.8 g. 4-Ph isomer (VIII) of VII, m. 60-1° (from petr. ether). VII (20 g.) and 14 g. dry EtOAc added with stirring to 9.2 g. NaOEt in 125 cc. dry C₆H₆, the mixture refluxed 21 hrs. with stirring, cooled, poured into 4.4 g. NaOH in 90 cc. H₂O, and the Et₂O layer worked up gave 9.3 g. 2-acetyl-6-phenylpyridine (IX), m. 75-6° (from petr. ether). VIII (14.5 g.) gave similarly 7.5 g. 4-Ph isomer of IX, m. 75-6°. 2-Bromo-4-phenylpyridine (6 g.) and 6 g. Cu powder in 12 g. Ph₂ heated 3 hrs. with stirring at 250° the mixture finely powdered and extracted with concentrated HCl, the acid solution basified with aqueous NaOH-NH₄OH and extracted with Et₂O, and the extract worked up gave 0.7 g. 4,4′-diphenyl-2,2′-bipyridine (X), m. 187-8°. 2-Bromo-4-ethylpyridine (28 g.) and 43.5 g. Cu powder heated 1 hr. at 200-20° and worked up in the usual manner gave 4.0 g. di-Et analog (XI) of X, colorless liquid, b_0.3 147-50°. XI in Et₂O treated with dry HCl gave XI.2HCl, m. 193-5° (from EtOH-Me₂CO). The appropriate 2-acetylpyridine or -quinoline (not over 5 g., 2.2 molar proportions), 1 mole BzH, 0.3 mole NH₄OAc, and 9 moles 28% NH₄OH heated 5 hrs. in a sealed tube at 250°, and the product isolated with hot C₆H₆ gave the following 2,6-bis-substituted-2-pyridyl)-4-phenylpyridines (substituent, % yield, and m.p. given): 4-Me, 18, 328-9° (from C₆H₆); 4-Et, 16, 114-15° (from petr. ether); 6-Ph, 17, 190-1° (from petr. ether); 4-Ph, 21, 257-8° (from EtNO₂). 2,6Bis(2-quinolyl)-4-phenylpyridine, 18, 295-6° (from C₆H₆). In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Recommanded Product: 2-Bromo-4-phenylpyridine).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 2-Bromo-4-phenylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel diversely substituted 1-heteroaryl-2-imidazolines for fragment-based drug discovery was written by Krasavin, Mikhail. And the article was included in Tetrahedron Letters in 2012.Related Products of 54151-74-5 This article mentions the following:

A palladium-catalyzed Buchwald-Hartwig arylation protocol has been applied to achieve high-yielding N-heteroarylation of a diverse set of privileged 2-imidazolines, e.g. I. The resulting compounds are of interest as a novel type of mol. tool for fragment-based drug discovery. The potential for combining two 2-imidazoline moieties in a heteroarene-linked dimer via sequential Pd-catalyzed arylation has been demonstrated. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Related Products of 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oxygen-Bridged Triphenylamine Units Tuning the Photophysical Properties of Classical Phosphorescent Iridium(III) Complex was written by Cao, Yibo;Song, Jialiang;Li, Gang;Zheng, Ying;Shi, Chao;Li, Qiuxia;Yuan, Aihua. And the article was included in ChemistrySelect in 2021.Application of 54151-74-5 This article mentions the following:

A new yellow phosphorescent iridium(III) complex Ir(ppybop)₂acac with two oxygen-bridged triphenylamine units were prepared and investigated. The cyclometalating ligand ppybop was synthesized by the efficient Suzuki-Miyaura cross-coupling reaction of oxygen-bridged triarylamine unit based boron reagent 1-a and 2-(4-Bromophenyl)pyridine, and the acetylacetone (acac) was used as an auxiliary ligand. Notably, the complex Ir(ppybop)₂acac measured with a fluorescence spectrophotometer can show a larger red shift emission (λ_em = 568 nm), a narrower full width at half maximum (FWHM = 59 nm), a longer emission lifetime (τ[b] = 3127 ns) and a better solubility in comparison with the classical green complex Ir(ppy)2acac (λ_em = 520 nm, FWHM = 70 nm, τ[b] = 1206 ns). In addition, the DFT calculation results indicate that the strong electron-donating ability of the unit can lead to the unusual ligand-to-metal charge transfer (3LMCT) excited state characteristics of Ir(ppybop)2acac, which is completely different from the metal-to-ligand charge transfer (3MLCT) in Ir(ppy)₂acac. This result can provide a new strategy for the design of new phosphorescent iridium(III) complexes. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Application of 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oxygen-Bridged Triphenylamine Units Tuning the Photophysical Properties of Classical Phosphorescent Iridium(III) Complex was written by Cao, Yibo;Song, Jialiang;Li, Gang;Zheng, Ying;Shi, Chao;Li, Qiuxia;Yuan, Aihua. And the article was included in ChemistrySelect in 2021.Application of 54151-74-5 This article mentions the following:

A new yellow phosphorescent iridium(III) complex Ir(ppybop)₂acac with two oxygen-bridged triphenylamine units were prepared and investigated. The cyclometalating ligand ppybop was synthesized by the efficient Suzuki-Miyaura cross-coupling reaction of oxygen-bridged triarylamine unit based boron reagent 1-a and 2-(4-Bromophenyl)pyridine, and the acetylacetone (acac) was used as an auxiliary ligand. Notably, the complex Ir(ppybop)₂acac measured with a fluorescence spectrophotometer can show a larger red shift emission (λ_em = 568 nm), a narrower full width at half maximum (FWHM = 59 nm), a longer emission lifetime (τ[b] = 3127 ns) and a better solubility in comparison with the classical green complex Ir(ppy)2acac (λ_em = 520 nm, FWHM = 70 nm, τ[b] = 1206 ns). In addition, the DFT calculation results indicate that the strong electron-donating ability of the unit can lead to the unusual ligand-to-metal charge transfer (3LMCT) excited state characteristics of Ir(ppybop)2acac, which is completely different from the metal-to-ligand charge transfer (3MLCT) in Ir(ppy)₂acac. This result can provide a new strategy for the design of new phosphorescent iridium(III) complexes. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Application of 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem