Category: 54189-82-1

Application of 54189-82-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54189-82-1, name is 6-Chloro-N-methylnicotinamide, molecular formula is C7H7ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 101 Preparation of N-Methyl-6-(1-oxo-2-(2-(pyrrolidin-1-yl)ethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yloxy)nicotinamide hydrochloride A suspension of NaH (60% dispersion in mineral oil, 0.06 g, 5.4 mmol) in DMF at room temperature was treated dropwise over a 15 min period with a solution of 6-hydroxy-2-(2-(pyrrolidin-1-yl)ethyl)-3,4-dihydroisoquinolin-1(2H)-one (0.2 g, 2.7 mmol) in DMF, stirred at room temperature for 30 min, treated with a solution of 6-chloro-n-methylnicotinamide in DMF, heated at 100 C. overnight, cooled to room temperature, diluted with water and extracted with CH2Cl2. The combined extracts were washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by ISCO CombiFlash chromatography (silica, 0-15% methanol in methylene plus 0.5% ammonium hydroxide) to afford the free amine of the title product as a colorless oil. The oil was dissolved in ethanol, treated with ethereal HCl, stirred and filtered. The filtercake was washed with ether and dried to provide the title compound as a white solid, 30 mg (10%), mp 228-230 C.; identified by NMR and mass spectral analyses. MS (ES) m/z 395.2 [M+H]+.

According to the analysis of related databases, 54189-82-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wyeth; US2009/69300; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 54189-82-1, 6-Chloro-N-methylnicotinamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H7ClN2O, blongs to pyridine-derivatives compound. COA of Formula: C7H7ClN2O

To a solution of 3-cyclobutyl-3-azaspiro[5.5]undecan-9-ol (0.44 mmol) in DMSO (4 ml), sodium hydride (65% disp. in mineral oil, 0.8 mmol) is added. After 30 min, 6-chloro-N-methyl-nicotinamide (0.26 mmol) is added and the reaction mixture is heated to 120 C. overnight. The reaction is allowed to cool to rt and then partitioned between EA and water. The EA layer is separated and the water layer is extracted with EA. The combined organic layer is washed with water, and then with brine, dried (Na2SO4) and filtered. The mixture is concentrated in vacuo and the residue is purified with PTLC to afford the title compound. MS (Method 1): 358.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54189-82-1, 6-Chloro-N-methylnicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; Xu, Yuelian; Caldwell, Timothy M.; Xie, Linghong; Chenard, Bertrand L.; US2008/247964; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54189-82-1, name is 6-Chloro-N-methylnicotinamide. A new synthetic method of this compound is introduced below., SDS of cas: 54189-82-1

A mixture of 5-[(l-cyclobutylpiperidin-4-yl)oxy]-l,3-dihydrospiro[indene-2,4′- piperidine] (50 mg), 6-chloro-N-methylnicotmamide (37 mg) and K2CO3 (30 mg) in DMSO (5 mL) is heated at 12O0C overnight. The mixture is cooled to rt and water (20 mL) is added. The resulting mixture is extracted with DCM (20 mL x 2). The combined organic phase is washed with water, dried over Na2SO4, and the solvent is removed to give a residue which is purified through PTLC (5% TEA in EtOAc) to give the title compound. MS (M+ 1) 475.6.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 54189-82-1, 6-Chloro-N-methylnicotinamide.

Reference:
Patent; NEUROGEN CORPORATION; WO2009/39431; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 54189-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54189-82-1, name is 6-Chloro-N-methylnicotinamide. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of (R)-2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-ol (Example 47) in N,N-dimethylformamide (0.06 M) under a dry nitrogen atmosphere is placed in a microwave vial and stirred. Sodium hydride or a 1 M solution of sodium bis(trimethylsilyl)amide in tetrahydrofuran (1.2 equivalents) is added to the reaction mixture and stirring is continued for 45 minutes. 6-Chloro-N-methyl-3-pyridinecarboxamide (CAS No.54189-82-1, 1.2 equivalents) is added to the reaction mixture and stirring is continued for 2-3 hours at 100 C. under microwave irradiation with the cooling air remaining on for the duration of the heating cycle. The reaction mixture is cooled to ambient temperature, dried (MgSO4), and filtered. The filtrate is concentrated under reduced pressure and the residue is purified by column chromatography on silica gel, eluting with 98:2 dichloromethane/2 M NH3 in methanol. Fractions containing product are combined and concentrated under reduced pressure to give (R)-N-methyl-6-(2-(3-(piperidin-1-yl)pyrrolidin-1-yl)benzo[d]thiazol-6-yloxy)nicotinamide.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54189-82-1, 6-Chloro-N-methylnicotinamide.

Reference:
Patent; Abbott Laboratories; US2009/163464; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54189-82-1, name is 6-Chloro-N-methylnicotinamide, molecular formula is C7H7ClN2O, molecular weight is 170.6, as common compound, the synthetic route is as follows.category: pyridine-derivatives

6-({2-[(2/?,5/?)-2>5-dimethyl-1-pyrrolidinyl]-2,3-dihydro-1H-inden-5-yl}oxy)-yV-methyl- 3-pyridinecarboxamide (E9) Sodium hydride (22mg, 0.55mmol, 60% in mineral oil) was added to a solution of 2-[(2f?,5R)-2,5-dimethyl-1-pyrrolidinyl]-2,3-dihydro-1H-inden-5-ol (may be prepared as described in Description 8) (105mg, 0.45mmol) in dimethylformamide (4ml) and the resulting mixture was stirred at room temperature for 20 minutes. 6-Chloro-Lambda/-methyl-3- pyridinecarboxamide (93mg, 0.55mmol; may be prepared as described in Description 10 of WO2004056369) was added and the mixture heated at 9O0C under argon for 21 hours. The mixture was then cooled to room temperature, applied to an sex ion exchange column and eluted with methanol and then a solution of ammonia in methanol (2M). The basic fractions were evaporated under reduced pressure and the residue purified on the mass directed autoprep to afford the title compound (E9); MS (ES+) m/e 366 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54189-82-1, 6-Chloro-N-methylnicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/61193; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem