Category: 54221-93-1

Application of 54221-93-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54221-93-1, name is 2,6-Dimethylisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

4-???2,6-????????????(3)2g?2,6-??????????(2)(??)?100ml?????????1ml?98%??24????????????????NaHCO3???????????60ml?CHCl3?5??????????????????????Na2SO4?????????????????????????50ml??????4????????????????????????????????????????????[?:???????/CH2Cl2(50/50)?CH2Cl2]????1g?4-???2,6-????????????(3)????

According to the analysis of related databases, 54221-93-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CIS BIO INTERNATIONAL, CIS; JP2004/509075; (2004); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 54221-93-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54221-93-1, name is 2,6-Dimethylisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

4-???2,6-????????????(3)2g?2,6-??????????(2)(??)?100ml?????????1ml?98%??24????????????????NaHCO3???????????60ml?CHCl3?5??????????????????????Na2SO4?????????????????????????50ml??????4????????????????????????????????????????????[?:???????/CH2Cl2(50/50)?CH2Cl2]????1g?4-???2,6-????????????(3)????

According to the analysis of related databases, 54221-93-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CIS BIO INTERNATIONAL, CIS; JP2004/509075; (2004); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 54221-93-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54221-93-1, name is 2,6-Dimethylisonicotinic acid. A new synthetic method of this compound is introduced below.

A mixture of 2 g of 2,6-dimethylisonicotinic acid (2) (unpurified), 100 ml of methanol and 1 ml of 98% sulfuric acid is refluxed for 24 hours. After cooling, the reaction medium is neutralized with saturated NaHCO3 solution and then extracted five times with 60 ml of CHCl3. The combined chloroform phases are then dried over Na2SO4 and then concentrated. The resulting solid is then extracted four times with 50 ml of ether, after which the ether phase is concentrated. Chromatography on alumina [gradient: cyclohexane/CH2Cl2 (50/50) to pure CH2Cl2] of the white residue obtained gives 1 g of 4-methyl-2,6-dimethyl isonicotinate (3). [0141] m.p.: 45-47 C. [0142] TLC: Rf: 0.3 [SiO2/CH2Cl2-MeOH (97/3)][0143] HPLC: Tr: 2.4 [0144] UV: CHCl3: 290.6 nm (3650) [0145] NMR: 1H CDCl3; internal reference TMS [0146] 2.59 (s, 6H, CH3); 3.93 (s, 3H, CO2CH3); 7.51 (s, 2H, Py) [0147] 13C CDCl3; internal reference 77.0 ppm [0148] 24.5 (CH3); 52.5 (OCH3); 119.5 (Ct); 137.9, 158.9 (Cq); [0149] 166.1 (CO). [0150] MS (EI): 165 (M+, 24); 134 (M+-OCH3, 13); 106 (M+-CO2Me)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,54221-93-1, its application will become more common.

Reference:
Patent; Autiero, Herve; Bazin, Herve; Mathis, Gerard; US2004/92726; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem