Category: 54664-55-0

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54664-55-0, name is 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine, molecular formula is C8H8ClN, molecular weight is 153.61, as common compound, the synthetic route is as follows.Product Details of 54664-55-0

Example A8; Preparation of intermediate 21A mixture of 4-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine (0.0520 mol), Pd(OAc)2 (0.1 g), l,3-bis(diph-rhohosrhohino)rhororhoane (0.4 g) and KOAc (10 g) in TetaF (100 ml) and H2O (20 ml) was stirred under 50 atm. of CO for 16 hours at 150 0C. The mixture was evaporated and water was added. The precipitate was filtered off and dried, yielding 9.20 g (100%) of intermediate 21.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54664-55-0, 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/118903; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 54664-55-0, 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H8ClN, blongs to pyridine-derivatives compound. HPLC of Formula: C8H8ClN

Step 3 : 4-chloro-6,7-dihydro-5H-cvclopentarb1pyridine-l-oxide To a solution of 4-chloro-6,7- dihydro-5H-cyclopenta[b]pyridine (38 g, 247 mmol) and methyl trioxorhenium(VII) (400 mg, 1.61 mmol) in DCM (250 mL) was added hydrogen peroxide (76 mL, 742 mmol, 30%wt). After addition, the mixture was stirred at 20C for 48h. TLC showed SM was consumed. The mixture was diluted with DCM (300 mL) and water (150 mL), quenched with solid powder sodium sulfite portionwise until potassium iodide-starch test paper (the paper wetted by lmol/L aqueous HC1) did not turn blue. The organic phase was separated and the aqueous phase was extracted with CHCI3 (500 mL chi 3). The combined organic phases were dried over Na2S04, filtered and concentrated to give the title compound, which was used for the next step without further purification.

The synthetic route of 54664-55-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MERTZ, Eric; EDMONDSON, Scott, D.; SO, Sung-Sau; SUN, Wanying; LIU, Weiguo; NEELAMKAVIL, Santhosh, F.; GAO, Ying-Duo; HRUZA, Alan; ZANG, Yi; ALI, Amjad; MAL, Rudrajit; HE, Jiafang; KUANG, Rongze; WU, Heping; OGAWA, Anthony, K.; NOLTING, Andrew, F.; (152 pag.)WO2016/168098; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem