Category: 5467-69-6

Reference of 5467-69-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5467-69-6, name is 6-Methoxy-2-methyl-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of intermediate 74 (2 g, 0.012 mol) in H20/MEOH 1: 1 (40 mL), were added NH4CI (2.2 g, 3.5 eq. ) and Fe powder (2.3 g, 3.5 eq. ). The reaction mixture was stirred at 80C for 16 hr. Fe was then filtered and washed with MeOH. The MeOH was evaporated, H20 was added and the aqueous solution was extracted with EtOAc (3X50 mL). The combined organic extracts were dried over anh. NA2SO4, the solids were filtered and the solvent evaporated to dryness to give the title compound (1.35 g, 81 %) as a brown oil. NMR (‘H, CDCI3) : 8 6.9 (d, 1 H), 6.4 (d, 1 H), 3.8 (s, 3H), 2.33 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine.

Reference:
Patent; SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC; GLAXO GROUP LIMITED; WO2004/62665; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H8N2O3, blongs to pyridine-derivatives compound. Computed Properties of C7H8N2O3

Step 1: A solution of commercially available 6-methoxy-2-methyl-3-nitropyridine (183 mg, 1.19 mmol), [5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methanol (see preparation 1, 320 mg,1.13 mmol) and PPh3 (563 mg, 2.15 mmol) in toluene (30 ml) was cooled to 0C, DIAD (434 mg, 2.15 mmol) was added and the mixture was stirred at room temperature for 12 h. The solution was concentrated under reduced pressure to give a crude residue which was purified by flash chromagraphy to give 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((6-methyl-5-nitropyridin-2-yloxy)methyl) isoxazole (340 mg, 0.810 mmol; 68% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Phenex Pharmaceuticals AG; EP2128158; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5467-69-6, Adding some certain compound to certain chemical reactions, such as: 5467-69-6, name is 6-Methoxy-2-methyl-3-nitropyridine,molecular formula is C7H8N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5467-69-6.

Preparation 7 2-Methoxy-5-Nitro-6-(2-Dimethylaminoethen-1-yl)pyridine To 2-methoxy-5-nitro-6-methylpyridine (29.39 g, 175 mmol) dissolved in 300 mL of N,N-dimethylformamide was added dimethylformamide dimethylacetal (120 mL, 896 mmol) and triethylamine (1 mL). The bright red reaction mixture was heated at 120 C. for 2 hours, then concentrated in vacuo to provide 38.90 g of the title compound as a red solid, which was used in Preparation 13 without further purification.

According to the analysis of related databases, 5467-69-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eli Lilly and Company; US6358972; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem