Category: 5470-22-4

Adding a certain compound to certain chemical reactions, such as: 5470-22-4, 4-Chloropicolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4-Chloropicolinic acid, blongs to pyridine-derivatives compound. Quality Control of 4-Chloropicolinic acid

General procedure: To a solution of the picolinic acid S7 (25.0 mmol) in DCM (100 mL) at room temperature was added SOCl2 (20 mL) and some drops of dry DMF. The reaction was allowed to stir at 50 C for 3 hours. The solvent was then removed under reduced pressure to afford the corresponding crude acid chloride (S8). Then DCM (40 mL) was added and the solution was cooled to 0C followed by dropwise addition of NEt3 (75.0 mmol, 3.0 eq) and N,O-dimethylhydroxylamine (50.0mmol, 2.0 eq). The reaction mixture was stirred at rt overnight, extracted by DCM, the organic layerwas dried over Na2SO4 and the solvent was evaporated, then purified by flash chromatography to gain the corresponding amides (S9).

The synthetic route of 5470-22-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jin, Liang; Yao, Qi-Jun; Xie, Pei-Pei; Li, Ya; Zhan, Bei-Bei; Han, Ye-Qiang; Hong, Xin; Shi, Bing-Feng; Chem; vol. 6; 2; (2020); p. 497 – 511;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 5470-22-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5470-22-4, name is 4-Chloropicolinic acid, molecular formula is C6H4ClNO2, molecular weight is 157.55, as common compound, the synthetic route is as follows.

A solution of 4-chloropicolinic acid (0.78 g, 5 mmol) in aqueous dimethylamine (40%, 10 ml) was stirred at 100 C for 5 h in a sealed tube. The resulting solution was concentrated in vacuo, then dissolved in EtOAc (50 ml) and washed with saturated aqueous NaHCO3 (50 ml) twice. The organic phase was dried over MgSO4 and evaporated in vacuo to afford compound 16 (0.79 g, 95%). 1H NMR (DMSO-d6, 400 MHz): delta 8.20 (d, J=7.48 Hz, 1H), 7.43 (d, J=2.98 Hz, 1H), 7.10 (dd, J1=3.01 Hz, J2=7.53 Hz, 1H), 3.27 (s, 6H). ESI-HRMS: m/z calcd for C8H10N2O2 [M+H]+ 189.0634 found 189.0638.

The chemical industry reduces the impact on the environment during synthesis 5470-22-4, I believe this compound will play a more active role in future production and life.

Reference:
Article; Lu, Chaocao; Htan, Bu; Fu, Shitao; Ma, Chunmiao; Gan, Quan; Tetrahedron; vol. 75; 30; (2019); p. 4010 – 4016;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5470-22-4, name is 4-Chloropicolinic acid, molecular formula is C6H4ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 4-Chloropicolinic acid

A mixture of 4-chloropicolinic acid (10.0 g, 63.4 mmol), thionyl chloride (40 ml) and a catalytic amount of DMF were heated at 80 C for 3 h. Then the reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was dissolved in 30 ml of CH2Cl2 in an ice-bath, then added to a 25% aqueous solution of ammonia (60 ml) at a rate which kept the internal temperature below 7 C with constant stirring. After 1 h, the precipitate was filtrated, washed with water (3 × 50 ml) and dried in vacuo to afford compound 2 (9.2 g, 93% yield) as a yellow solid, mp 161-162 C; 1H NMR (DMSO-d6, 400 MHz): delta 7.74-7.76 (dd, J = 1.8 and 5.3 Hz, 1H), 7.80 (br s, 1H), 8.03 (d, J = 1.8 Hz, 1H), 8.20 (br s, 1H), 8.62 (d, J = 5.3 Hz, 1H); ESI-MS m/z: 157[M+H]+; Anal. Calcd for C6H5ClN2O (%): C 46.03, H 3.22, N 17.89; Found: C 45.98, H 3.27, N 17.94.

With the rapid development of chemical substances, we look forward to future research findings about 5470-22-4.

Reference:
Article; Zhan, Wenhu; Li, Yanyang; Huang, Weiping; Zhao, Yanjin; Yao, Zhenglin; Yu, Shanyou; Yuan, Shoujun; Jiang, Falong; Yao, Shan; Li, Shuxin; Bioorganic and Medicinal Chemistry; vol. 20; 14; (2012); p. 4323 – 4329;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 5470-22-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5470-22-4 as follows.

Compound 5 was prepared according to a modified procedure (WO2013/057253). To a suspension of the commercially available 4-chloro-pyridine-2-carboxylic acid 4 (5.0 g, 31.84 mmol) in dichloromethane (135 ml) at 0 C was added oxalyl chloride (4.8 g, 38.21 mmol), followed by a slow addition of catalytic amount of dimethylformamide (0.55 ml). The resulting mixture was stirred at room temperature for 2 h. After this time, the mixture was concentrated to dryness under reduced pressure. The solid residue was solubilized in methanol (55 ml) and was stirred at room temperature for another 16 h. The mixture was concentrated to dryness under reduced pressure, and the residue re-suspended with 5% aq. NaHCC>3. The product was extracted with EtOAc (2 x 20 ml). The combined organic layer was washed with brine (2 chi 10 ml), dried over anhydrous MgS04, filtered and concentrated to dryness under reduced pressure to afford 5 (4.0 g, 74%) as a beige solid. XH N MR (300 M Hz, CDCI3): delta 8.63 (d, J = 5.0 Hz, 1H), 8.12 (dd, J = 2.0, 0.5 Hz, 1H), 7.48 (dd, J = 5.0, 2.0 Hz, 1H), 4.00 (s, 3H). 13C N MR (75 MHz, CDCI3): delta 164.7, 150.7, 149.3, 145.5, 127.2, 125.7, 53.3. HRMS (APPI) calcd. for C7H7CI N02+ [M+H]+ 172.0160, found: 172.0156.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5470-22-4, its application will become more common.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT CURIE; UNIVERSITY OF TEXAS AT AUSTIN; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE; RODRIGUEZ, Raphael; ZACHARIOUDAKIS, Emmanouil; KUNALINGAM, Lavaniya; BARTOLI, Alexandra; MILLER, Kyle; AGARWAL, Poonam; (41 pag.)WO2017/102934; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 5470-22-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-22-4, name is 4-Chloropicolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of (56) 4-(4-benzothiazol-2-yl-phenylamino)-pyridine-2-carbogylic acid methylamide: [Show Image] Step 1: A mixture of methylamine hydrochloride (544 mg, 8.05 mmol) and 4-chloropicolinic acid (296 mg, 2.30 mmol) in DMF (5 mL) was treated with EDC*HCl (661 mg, 3.45 mmol) and DIEA (2.0 mL, 11.5 mmol) at r.t. for 40 h. was continued over night (LCMS: ST179_21h). Reaction mixture was partitioned between aq. satd NaHCO3 (50 mL) and CHCl3 (3 x 35 mL). Combined org. phases were washed with aq. satd NH4Cl (2 x 50 mL) and dried over MgSO4. The organic phase was purified by chromatography on silica gel using petroleum ether/ethyl acetate 2:1 1 to pure ethyl acetate. Product was finally purified by prep. HPLC. Product fraction was again partitioned between satd aq. NaHCO3 (20 mL) and CHCl3 (3 x 30 mL) to remove any formic acid still present from HPLC, and dried over MgSO4. Resulting oil was dried only under reduced pressure, 25 mbar, as product is volatile at high vacuum.

According to the analysis of related databases, 5470-22-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; 4SC AG; EP1746096; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 5470-22-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5470-22-4, name is 4-Chloropicolinic acid, molecular formula is C6H4ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0216] To a suspension of 4-chloropyridine-2-carboxylic acid (4.5 g, 29.0 mmol) in methylene chloride (120 mL) was added oxalyl chloride (3.0 mL, 1.2 eq) under Ar2. The reaction was cooled to 0 C., added 500 uL of DMF. A large amount of gas was generated in situ. The reaction was stirred at room temperature for 1.5 h then concentrated. Dry MeOH (50 mL) was added to the crude acyl chloride residue. The reaction was stirred at room temperature for 0.5 h then quenched with NaHCO3 (5%) to neutral, extracted with EtOAc, and washed with brine. The combined organics were dried over MgSO4, filtered and concentrated in vacuo to give 5.0 g of crude solid which was triturated with 5% EtOAc/hexane to give the desired intermediate methyl ester as a light yellow solid (4.5 g, 90%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-22-4, 4-Chloropicolinic acid.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US2004/186114; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem