Category: 5470-70-2

5470-70-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-70-2, name is Methyl 6-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: PtO2 (3.00 g) was added to a methanol solution (200 mL) of methyl 6-methylpyridine-3-carboxylate(18.00g, 119.08 mmol), and then added with water (10mL) and hydrochloric acid (20mL); under H2 (50psi), the reaction solutionwas heated to 50C and stirred for 15 h. TLC showed that the reactants were completely consumed; then solid werefiltered, and the filtrate was concentrated under reduced pressure, residues were dissolved in toluol (100 mL), then thesolvent toluol was spin-dried to obtain methyl 6-methylpiperidyl-3-carboxylatewhich was yellow oily matter (18.00 g, yieldwas 96.15%). The value of C8H15NO2[M+H]+157 was calculated using MS ESI, was 157.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-70-2, Methyl 6-methylnicotinate.

Reference:
Patent; Wuxi Fortune Pharmaceutical Co., Ltd; WU, Hao; MAO, Weiwei; FAN, Lili; DING, Charles Z.; CHEN, Shuhui; WANG, Fei; HU, Guoping; LI, Jian; (85 pag.)EP3248980; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5470-70-2, name is Methyl 6-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of methyl 6-methylnicotinate (30 g, 197 mmol) and NBS (52.7 g, 296 mmol) in CC14 (300 mL) was added AIBN (3 g). Then the reaction mixture was heated to 80 C and stirred overnight. Then the reaction mixture was cooled and filtered, and the filtrate was concentrated under vacuum to give a crude residue. The crude residue was purified by silica gel column chromatography (PE/EA = 5/1) to give methyl 6-(bromomethyl)nicotinate (10 g, yield 22.2 %). 1H NMR (400MHz, CDC13) 5 = 9.17 (d, J=1.5 Hz, 1H), 8.30 (dd, J=2.0, 8.0 Hz, 1H), 7.54 (d, J=8.0 Hz, 1H), 4.58 (s, 2H), 3.96 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5470-70-2, Methyl 6-methylnicotinate.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Hao; KIM, Ronald M.; LIU, Jian; GAO, Xiaolei; BOGA, Sobhana Babu; GUIADEEN, Deodialsingh; KOZLOWSKI, Joseph; YU, Wensheng; ANAND, Rajan; YU, Younong; SELYUTIN, Oleg B.; GAO, Ying-Duo; LIU, Shilan; YANG, Chundao; WANG, Hongjian; WO2014/114185; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-70-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5470-70-2, name is Methyl 6-methylnicotinate, molecular formula is C8H9NO2, molecular weight is 151.16, as common compound, the synthetic route is as follows.

A mixture of methyl 6-methylnicotinate (5.0 g, 33.0 mmol), 12 (8.4 g, 33.2 mmol) andTFA (7.5 mL, 11.5 g, 0.1 mol) in DMSO (100 mL) was heated to 160¡ãC for 2 h. Themixture was allowed to cool to RT and poured into a 1 N solution ofNa2S2O3 (aq.) (0.5L) solution, made alkaline using NaOH (2 N) and extracted with EtOAc (3 x 0.2 L).The combined organic layers were dried (Na2SO4) and concentrated in vacuo. The residue was dissolved in DCM and applied on a short pad of silica. The product was eluted with EtOAc to afford the product as a yellowish solid (3.8 g, 23 mmol, 70percent).

Statistics shows that 5470-70-2 is playing an increasingly important role. we look forward to future research findings about Methyl 6-methylnicotinate.

Reference:
Patent; AAPA B.V.; HEERES, Andre; WILLIGERS – HOGG, Sandra; BORST, Marcus Leonardus Gerardus; DROeGE, Melloney Joyce; WO2015/69110; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5470-70-2, name is Methyl 6-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows. 5470-70-2

In a 500 ml round-bottomed flask at room temperature under nitrogen, methyl 6-methyl-3- pyridinecarboxylate (10 g, 66.2 mmol) was dissolved in dry tetrahydrofuran (100 ml) to give a orange solution. The mixture was then cooled down to 00C and lithium aluminum hydride (36.4 ml, 72.8 mmol) was added dropwise, keeping internal temperature below 00C. At the end of addition the ice-bath was removed and the resulting solution was stirred at room temperature for 3 hours. The mixture was slowly additioned with 2.73 ml of water, 2.73 ml of NaOH 1 M and 8.2 ml of water. The resulting yellow suspension was stirred at room temperature for -30 minutes and then filtered over a Gooch funnel. The solid was washed with Et2O (3 x 100 ml). The combined organics were dried over Na2SO4, filtered and concentrated to give the title product (7.48 g) as orange oil.

Statistics shows that 5470-70-2 is playing an increasingly important role. we look forward to future research findings about Methyl 6-methylnicotinate.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/80637; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A common compound: 5470-70-2, name is Methyl 6-methylnicotinate,molecular formula is C8H9NO2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 5470-70-2

[Step 1] Synthesis of methyl 6-bromomethylnicotinate methyl 6-methylnicotinate (1 g) was dissolved in carbon tetrachloride (100 ml), and N-bromosuccinimide (1.3 g) was added. The mixture was heated under reflux in an argon atmosphere for 8 hours, and allowed to cool. The precipitated crystals were removed by filtration, and the solvent was evaporated from the filtrate under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/methylene chloride=1:3) to obtain the title compound (540 mg, 35%). m.p.: 75.2-76.3 C. IR spectrum (KBr tab.) nucm-1: 1728, 1713, 1595, 1435, 1286, 1124, 1103. NMR spectrum (*DMSO-d6) delta ppm: 9.05 (1H, s), 8.34-8.30 (1H, m), 7.71 (1H, d, J=7.9 Hz), 4.77 (2H, s), 3.89 (3H, s).

With the rapid development of chemical substances, we look forward to future research findings about 5470-70-2.

Reference:
Patent; Mochida Pharmaceutical Co., Ltd.; US6018046; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding some certain compound to certain chemical reactions, such as: 5470-70-2, name is Methyl 6-methylnicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5470-70-2. 5470-70-2

Compound 1 (3g, 19.85mmol) was dissolved in MeOH (15ml) and NH2NH2-H2O (5.46g, 109.2mmol) was added. The mixture was stirred and raised to 900C for 2 hours. The mixture was concentrated and purified by chromatography to give desired product 2 as a white solid (2.Ig). Yield: 67percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5470-70-2.

Reference:
Patent; OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Dan; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; GOLDING, Louise; WO2010/139966; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5470-70-2, name is Methyl 6-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of methyl 6-methylnicotinate (2 g, 13.2 mmol, 1.0 eq), NBS (2.4 g, 13.2 mmol, 1.0 eq) and BPO (319 mg, 1.32 mmol, 0.1 eq) in CCI4 (40 mL) was stirred at 95 C under N2 overnight. Then the reaction was quenched with water (10 mL), extracted with DCM (50 mLx3). The combined organic layers were washed with brine (20 mL), dried over anhydrous Na2S04 and concentrated. The residue was purified on silica gel column (PE/EtOAc = 20/1) to afford a yellow solid (780 mg, 26%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5470-70-2, Methyl 6-methylnicotinate.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-70-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5470-70-2 as follows.

A solution of methyl 6-.methylnicolinate (15 g, 9934 n:imoi) and m-CPBA (18,8 g, 109.3mmol) in DCM (100 rnL) was stirred at room temperature for 4 hours. The reaction mixture wasquenched with 200 mL of saturated aqueous Na2SO3 and 100 mL of saturated aqueous NaHCO3. The resulting mixture was extracted with EA (20() mLx3), The combined EA layer was washed with brine and dried over Na2SO4. Filtered and the filtrate was concentrated. The residue was purified by colunm chromatography on silica gel (PE/EtOAc = 5/i) to afford 5-(methoxycarbonyi)-2-methylpyridine 1-oxide as a solid. MS-ESI (m/z): 168.2 (M+1) (LC-MSmethod 1); Ret. time: 0.32 mm).

The chemical industry reduces the impact on the environment during synthesis 5470-70-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph A.; BOGA, Sobhana Babu; GAO, Xiaolei; GUIADEEN, Deodialsingh; CAI, Jiaqiang; LIU, Shilan; WANG, Dahai; WU, Hao; YANG, Chundao; (261 pag.)WO2016/106628; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5470-70-2, Methyl 6-methylnicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5470-70-2, blongs to pyridine-derivatives compound. 5470-70-2

To a solution of methyl 6-methylnicotinate (25 g, 0.16 mol) in ethyl ether (620 mL) under nitrogen was added dropwise sodium bis(2-methoxyethoxy)aluminium hydride (Red-Al.(R).) (65wt.percent in toluene, 110 mL, 0.37 mol) at room temperature. The mixture was then heated to reflux for 1.5 hr. After cooling, the reaction mixture was quenched with water (500 mL) at 0 0C and the aqueous layer was extracted with EtOAc. The combined organic layers were dried over anhydrous MgSO4, filtered, and concentrated. The residue was purified by silica gel column to afford the title compound.

With the rapid development of chemical substances, we look forward to future research findings about 5470-70-2.

Reference:
Patent; RENOVIS, INC.; WO2009/110985; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5470-70-2, name is Methyl 6-methylnicotinate. This compound has unique chemical properties. The synthetic route is as follows. 5470-70-2

Intermediate G:; Methyl (2E)-3-r6-(Hvdroxyrnethyl)pyridin-3-yllacrylic acid The title compound was prepared by the following methodology:LiAIH4, Et2O MnO2, DCM Stage 1 Stage 2 MeO OMe Stage 3K2CO3, H2OTFAA, THF mCPBA, DCM Stage 5 Stage 4 Intermediate G; Stage 1 – Preparation of (6-methylpyridin-3-yl)methanol; To a suspension of lithium aluminium hydride (7.24g, 191mmol) in Et2O (400ml) at -780C was added via cannula over a period of one hour a solution of methyl 6-methylnicotinate (19.62g, 130mmol) in Et2O (20OmL). Once addition was completed, the mixture was stirred for a further 3h. Excess lithium aluminium hydride was quenched by dropwise addition of EtOAc (40 ml). The mixture was then warmed using a water-ice bath, and further quenched with sat NH4CI (50OmL). The ethereal layer was decanted, and EtOAc was added (50OmL). The mixture was stirred vigorously, and the organic layer was again decanted. The extraction procedure was repeated twice (50OmL EtOAc). The combined organic extracts were dried (MgSO4) and concentrated to yield the desired product (13.6g, 85percent). 1H NMR (300MHz, CDCI3) delta: 8.39 (1 H, s), 7.62 (1 H, dd, J=2.1 , 8.1 Hz), 7.14 (1 H, d, J=7.8Hz), 4.68 (2H, s), 2.54 (3H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5470-70-2, Methyl 6-methylnicotinate.

Reference:
Patent; CHROMA THERAPEUTICS LTD.; WO2008/40934; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem