Category: 55-22-1

Chemistry is an experimental science, Application In Synthesis of Isonicotinic acid, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 55-22-1, Name is Isonicotinic acid, molecular formula is C6H5NO2, belongs to pyridine-derivatives compound. In a document, author is Jana, Kalyanmoy.

A binuclear chloride bridged Cu(II) and a mononuclear Ni(II) complex: Synthesis, crystal structure, photo catalytic and biological studies

In the present paper, one new binuclear chloride bridged Cu(II) complex [Cl2Cu-(mu-Cl)-Cu(L)Cl-2] (1) and one mononuclear Ni(II) complex [Ni(L ‘)(2)](ClO4)(2) (2) where L = N-1-(pyridine-2-ylmethylene)-N-2-(2-(pyridine-2-ylmethyleneamino)ethyl)ethane-1,2-diamine derived from pyridine-2-aldehyde and diethylenetriamine, L’ = Piperidine-2-yl-N-(pyridine-2-ylmethylene)methanamine derived from pyridine-2-aldehyde and 2-aminomethylpiperidine have been synthesized and characterized by single crystal X-ray diffraction studies. The crystal structure of the binuclear Cu(II) complex (1) shows that the two square pyramidal Cu(II) moieties are joined through a single chloride (mu-Cl) bridge and the coordination environment around the two copper atoms are same, whereas the nickel ion in complex (2) has an octahedral geometry. The antibacterial study for metal salts, ligands and complexes were performed using Staphylococcus aureus. The result shows that among the complexes, complex (2) exhibits better antibacterial properties than complex (1). Optical band gaps of 3.3 and 3.1 eV for complexes 1 and 2 respectively reveal that both the complexes have some semiconducting properties. Photo catalytic activity and H2O2 sensing activity for both the complexes were also determined. The photo catalytic test was performed against Rhodamine B (RB), Methylene Blue (MB), Malachite Green (MG) and Bromocressol Green (BG) in presence of sunlight. Results of photo catalytic and H2O2 sensing tests have revealed that both the complexes have degradation ability against each dye but complex 1 have only H2O2 sensing properties. DNA binding ability of the complexes was done by absorption titration, ethidium bromide displacement and viscosity measurement studies. Furthermore, molecular docking studies for complex 2 were also performed with B-DNA model sequence. It has been shown that complex 2 interacts with DNA through partial intercalation as well as minor-groove binding. The cell viable activity of the ligand, copper and nickel complexes were measured in vitro against the Hela cell and it shows that the metal complexes are biocompatible in nature. So the utility of this study is that the complexes under investigation can effectively be used as pharmaceutical components in several antibacterial drugs as they are biocompatible in nature and can also be used in waste dye degradation or separation process from water or to detect H2O2 widely used in food, cosmetic, pharmaceutical and paper industries.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 55-22-1, in my other articles. Application In Synthesis of Isonicotinic acid.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.55-22-1, Name is Isonicotinic acid, SMILES is OC(=O)C1=CC=NC=C1, belongs to pyridine-derivatives compound. In a document, author is Ali, Akbar, introduce the new discover, Application In Synthesis of Isonicotinic acid.

Facile synthesis, crystal growth, characterization and computational study of new pyridine-based halogenated hydrazones: Unveiling the stabilization behavior in terms of noncovalent interactions

The pyridine-based halogenated hydrazone derivatives (E)-N ‘-benzylidene-2-[(6 ”-chloroazin-2 ”-yl)oxy]acetohydrazide (6a), (E)-N ‘-(3 ‘-chlorobenzylidene)-2-[(6 ”-chloroazin-2 ”-yl)oxy]acetohydrazide (6b) and (E)-N ‘-(3 ‘-bromobenzylidene)-2-[(6 ”-chloroazin-2 ”-yl)oxy]acetohydrazide (6c) have been obtained using 6-chloro-2-hydroxypyridine. The structure of the products (6a-c) has been verified using X-ray crystallography and spectroscopic approaches. A single-crystal X-ray diffraction (SC-XRD) investigation showed that the structures are stabilized by intermolecular attractive forces. Additionally, density functional theory (DFT) has been adopted to explore the structural properties, vibrational spectra, noncovalent interactions and frontier molecular orbitals using the B3LYP/6-311 + G(d,p) level. The nonlinear optical properties of the title compounds were calculated using the CAM-B3LYP/6-311 + G(d,p) level. Frequency analysis confirmed the stability of the molecules, and an excellent correlation was observed between the DFT- and SC-XRD-based structural parameters. The SC-XRD analysis confirmed that the dimers of 6a, 6b and 6c are linked by hydrogen-bonding interactions. Natural bond orbital (NBO) analysis also reconfirmed the strength of intermolecular hydrogen-bonding and hyperconjugative interactions. NBO investigation was also utilized to analyze the atomic charges. Moreover, Fourier transform infrared and natural population analyses endorsed that there are significant N bond H… O & dbond;C hydrogen-bonding linkages in dimeric structures of the compounds. The hydrogen-bonding network and different sorts of hyperconjugative interactions are the main reasons for the stability of the products in the solid state. The highest occupied and lowest unoccupied molecular orbital energies and first-order nonlinear optical properties of these molecules are reported. The quantum chemical parameters were derived using frontier molecular orbital energies.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 55-22-1 is helpful to your research. Application In Synthesis of Isonicotinic acid.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55-22-1, Isonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55-22-1, blongs to pyridine-derivatives compound. Safety of Isonicotinic acid

General procedure: A mixture of o-aminobenzenethiol (1 mmol), carboxylic acid (1 mmol), N,N-diisopropylethylamine (1.5 mmol) and propylphosphonic anhydride (1 mmol, 50% w/w in AcOEt) was irradiated for 10 min under microwave at 100 C in a sealed tube. It was diluted with H2O, followed by alkalinization with saturated aqueous NaHCO3 solution. The precipitate was collected by filtration and washed thoroughly with H2O to afford the respective benzothiazole. If necessary, simple recrystallization was carried out in EtOH/H2O.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55-22-1, its application will become more common.

Reference:
Article; Wen, Xiaoan; Bakali, Jamal El; Deprez-Poulain, Rebecca; Deprez, Benoit; Tetrahedron Letters; vol. 53; 19; (2012); p. 2440 – 2443;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 55-22-1 , The common heterocyclic compound, 55-22-1, name is Isonicotinic acid, molecular formula is C6H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(A) 2-(4-Pyridinyl)benzoxazole A mixture of 2-aminophenol (10.9 g), isonicotinic acid (12.3 g) and polyphosphoric acid (250 g) is heated under a nitrogen atmosphere at 210 C. for 3 hours. The mixture is then cooled to 160 C. and slowly poured into 1 liter of water. The mixture is cooled by adding ice and neutralized with 50% sodium hydroxide solution yielding 16.2 g of crude product. Crystallization from hexane yields 14.8 g of the title compound, melting point 129-131 C.

The synthetic route of 55-22-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4169200; (1979); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem