Category: 55279-29-3

Wang, Ze-Kun; Lin, Jia-Le; Zhang, Yun-Chang; Yang, Chen-Wu; Zhao, Ya-Kun; Leng, Zheng-Wei; Wang, Hui; Zhang, Dan-Wei; Zhu, Jiang; Li, Zhan-Ting published the artcile< Synthesis and short DNA in situ loading and delivery of 4 nm-aperture flexible organic frameworks>, Related Products of 55279-29-3, the main research area is flexible organic framework short DNA loading delivery synthesis.

Five water-soluble flexible organic frameworks have been synthesized from a pyridinium-derived tetracationic tetraaldehyde and five diacylhydrazines (1 : 2) through the quant. formation of a hydrazone bond in water at ambient temperature Dynamic light scattering experiments reveal that the homogeneous frameworks display hydrodynamic diameters ranging from 68 nm to 167 nm, which can be tuned by changing the concentration of the components. Mol. modeling shows that, when adopting an ideal, extended conformation, the frameworks form an aperture of 4 nm diameter The new flexible frameworks are generally of low cytotoxicity. Fluorescence imaging and flow cytometric anal. demonstrate that the new flexible porous frameworks can quickly include single and double stranded DNA of 21 nucleotides and deliver the included DNA into both normal and cancer cells, with the percentage of delivered cells reaching up to 99.5%.

Materials Chemistry Frontiers published new progress about Bioconcentration. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Related Products of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phuan, P.-W.; Kozlowski, M. C. published the artcile< Product class 8: naphthyridines>, Product Details of C6H6N2O, the main research area is review naphthyridine cyclization ring transformation.

A review of synthetic methods to prepare naphthyridines which include cyclization and ring transformations.

Science of Synthesis published new progress about 55279-29-3. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Product Details of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Qingping; Deady, Leslie W. published the artcile< Synthesis of some benzo[b][1,6]naphthyridines and benzo[b][1,7]naphthyridines>, Reference of 55279-29-3, the main research area is benzonaphthyridine methyl; naphthyridine benzo.

Pfitzinger (1-benzylpiperidin-4-one with 7-methylisatin) and Friedlaender (3-aminopyridine-4-carbaldehyde with 2-methylcyclohexanone) syntheses, resp., were used to prepare the title azaacridines I and II containing a Me substituent peri to the central nitrogen. Oxidation of this group gave the corresponding aldehyde and carboxylic acid. In the [1,6] case, especially, the 10-position was also easily oxidized to give acridone analogs. Nitration occurred exclusively in the benzenoid rings.

Australian Journal of Chemistry published new progress about 55279-29-3. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Reference of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duplantier, Allen J.; Becker, Stacey L.; Bohanon, Michael J.; Borzilleri, Kris A.; Chrunyk, Boris A.; Downs, James T.; Hu, Lain-Yen; El-Kattan, Ayman; James, Larry C.; Liu, Shenping; Lu, Jiemin; Maklad, Noha; Mansour, Mahmoud N.; Mente, Scot; Piotrowski, Mary A.; Sakya, Subas M.; Sheehan, Susan; Steyn, Stefanus J.; Strick, Christine A.; Williams, Victoria A.; Zhang, Lei published the artcile< Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent D-Amino Acid Oxidase (DAAO) Inhibitors>, COA of Formula: C6H6N2O, the main research area is amino acid oxidase inhibitor hydroxyquinolinone preparation SAR.

3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding affinity was confirmed in a Biacore assay. Cocrystn. of 2 with the human DAAO enzyme defined the binding site and guided the design of new analogs. The SAR, pharmacokinetics, brain exposure, and effects on cerebellum D-serine are described. Subsequent evaluation against the rat DAAO enzyme revealed a divergent SAR vs. the human enzyme and may explain the high exposures of drug necessary to achieve significant changes in rat or mouse cerebellum D-serine.

Journal of Medicinal Chemistry published new progress about Cerebellum. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, COA of Formula: C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grivas, Spiros; Schuisky, Peter published the artcile< Synthesis of imidazonaphthyridines and -quinolines>, Application of C6H6N2O, the main research area is imidazonaphthyridine imidazoquinoline preparation; cyclocondensation aromatic aldehyde aminoimidazolinone.

Four 2-amino-3-methylimidazo[4,5-b][1,x]naphthyridines (x = 5-8), e.g., I, have been obtained from aromatic aldehydes and 2-amino-1-methyl-2-imidazolin-5-one in one step. The N1- and N3-Me isomes of 2-aminoimidazo[4,5-b]quinoline (II and III) were prepared from 2-nitrobenzaldehyde via the isolated E-isomers of imidazolin-5-ones.

Heterocycles published new progress about Cyclocondensation reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Application of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stockmann, Vegar; Fiksdahl, Anne published the artcile< Synthesis of novel 1,7-naphthyridines by Friedlaender condensation of pyridine substrates>, Recommanded Product: 3-Aminoisonicotinaldehyde, the main research area is naphthyridine pyridinyl aryl preparation Friedlaender.

The general ability of appropriate pyridyl compounds (aldehyde or ketone) to undergo Friedlaender condensation to give different 1,7-naphthyridines has been demonstrated. 2-(4-Pyridinyl)-4-methyl-1,7-naphthyridine was prepared from 3-amino-4-acetylpyridine (I) and 4-acetylpyridine (82%). The Friedlaender self-condensation of I is also reported. 2-(3-Aminopyridin-4-yl)-4-methyl-1,7-naphthyridine was obtained in 97% yield. 2-Aryl- and 2,3-diaryl-1,7-naphthyridines were prepared from 3-aminoisonicotinaldehyde (II) and aryl ketones (28-71%). The key substrates I and II are readily available via the improved pyridine nitration method.

Journal of Heterocyclic Chemistry published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Recommanded Product: 3-Aminoisonicotinaldehyde.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nivoliers, F.; Decormeille, A.; Godard, A.; Queguiner, G. published the artcile< 6H-indolo[3,2-b]naphthyridines. Aza-analogs of ellipticine>, Reference of 55279-29-3, the main research area is indolonaphthyridine; cyclocondensation indole aminopyridinecarboxaldehyde.

The indolonaphthyridines I (X = N, X1 = X2 = CH; X = X2 = CH, X1 = N; X = X1 = CH, X2 = N) were prepared by cyclocondensation of the indole II with the corresponding pyridines. E.g., II reacted with 1 mol equiv 3-aminopyridine-2-carboxaldehyde in MeOH/KOH at room temperature for 3 days gave I (X = N, X1 = X2 = CH). Quaternization of I with MeI occurred at the terminal pyridine ring.

Tetrahedron Letters published new progress about Cyclocondensation reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Reference of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheng, Chia-Chung; Yan, Shou-Jen published the artcile< The Friedlander synthesis of quinolines>, Electric Literature of 55279-29-3, the main research area is review Friedlander synthesis quinoline.

A review of the article The Friedlander synthesis of quinolines.

Organic Reactions (Hoboken, NJ, United States) published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Electric Literature of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bregman, Howard; Simard, Jeffrey R.; Andrews, Kristin L.; Ayube, Shawn; Chen, Hao; Gunaydin, Hakan; Guzman-Perez, Angel; Hu, Jiali; Huang, Liyue; Huang, Xin; Krolikowski, Paul H.; Lehto, Sonya G.; Lewis, Richard T.; Michelsen, Klaus; Pegman, Pamela; Plant, Matthew H.; Shaffer, Paul L.; Teffera, Yohannes; Yi, Shuyan; Zhang, Maosheng; Gingras, Jacinthe; DiMauro, Erin F. published the artcile< The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors>, HPLC of Formula: 55279-29-3, the main research area is sulfonamide glycine receptor analgesic pain.

Current pain therapeutics suffer from undesirable psychotropic and sedative side-effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activation is believed to reduce transmission of painful stimuli. Herein, the authors describe the identification and hit-to-lead optimization of a novel class of tricyclic sulfonamides as allosteric GlyR potentiators. Initial optimization of high-throughput screening (HTS) hit led to the identification of a compound, which demonstrated ex vivo potentiation of glycine-activated current in mouse dorsal horn neurons from spinal cord slices. Further improvement of potency and pharmacokinetics produced in vivo proof-of-concept tool mol. I (AM-1488) which reversed tactile allodynia in a mouse spared-nerve injury (SNI) model. Addnl. structural optimization provided highly potent potentiator II (AM-3607), which was cocrystd. with human GlyRα3cryst to afford the first described potentiator-bound x-ray cocrystal structure within this class of ligand-gated ion channels (LGICs).

Journal of Medicinal Chemistry published new progress about Analgesics. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, HPLC of Formula: 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anantoju, Kishore Kumar; Tharikoppula, Giri; Eppakayala, Laxminarayana; Maringanti, Thirumala Chary published the artcile< A facile synthesis of methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates>, Product Details of C6H6N2O, the main research area is pyridinecarboxaldehyde amino malonamide Friedlander condensation heterocyclization; naphthyridine carboxylic acid preparation esterification; phenylamino naphthyridine carboxylate preparation.

An efficient protocol for the synthesis of Me 2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates I (X = N, Y = Z = CH; Y = N, X = Z = CH; Z = N, X = Y = CH) was developed. The methodol. is cost effective and provided an efficient alternative to existing methods for the synthesis of 2-substituted naphthyridine-3-carboxylic acids.

International Journal of Chemical and Analytical Science published new progress about Aminals Role: RCT (Reactant), RACT (Reactant or Reagent). 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Product Details of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem