Category: 55279-29-3

Grivas, Spiros; Ronne, Erik published the artcile< Synthesis of four isomeric imidazonaphthyridines; three novel ring systems>, HPLC of Formula: 55279-29-3, the main research area is imidazonaphthyridine; Friedlaender reaction creatinine aminopyridinecarbaldehyde.

The novel 2-amino-1-Me derivatives of imidazo[4,5-b][1,x]naphthyridine, for example, I and II, were prepared via the Friedlaender reaction from the corresponding aminopyridinecarbaldehydes and creatinine in 65-85% yields. The ring systems I, II and their isomers were not reported previously.

Journal of Chemical Research, Synopses published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, HPLC of Formula: 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Song-Lin; Deng, Zhu-Qin published the artcile< Synthesis of quinolines and naphthyridines via catalytic retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes or nicotinaldehydes>, Application In Synthesis of 55279-29-3, the main research area is quinoline naphthyridine preparation copper catalyst retro aldol hydroxyketone aldehyde.

A Cu(I)-catalyzed retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes and nicotinaldehydes is reported that produces a range of quinolines and naphthyridines with high efficiency and selectivity. This reaction uses β-hydroxyketones as a regiospecific ketone-protected enolate source via copper-catalyzed retro-aldol Cα-Cβ bond cleavage. The in situ generated copper enolate undergoes kinetically favorable cyclization with ortho-amino aryl aldehydes to produce quinolines and naphthyridines in a chemo- and regioselective manner. The mild and weakly basic reaction conditions also suppress possible side reactions of benzaldehydes under strongly basic conditions, resulting in improved reaction yields.

Organic & Biomolecular Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (nicotine-). 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Application In Synthesis of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Hongyun; Datta Khanal, Hari; Rok Lee, Yong published the artcile< Iodine-Catalyzed Annulations of 2-Amino Carbonyls for Diverse 1-Azaxanthones, Quinolines, and Naphthyridines>, COA of Formula: C6H6N2O, the main research area is amino formylchromone enamine iodine catalyst tandem cycloaddition green chem; azaxanthone preparation; carbonyl aniline enamine iodine catalyst tandem cycloaddition green chem; quinoline preparation; aminonicotinaldehyde enamine iodine catalyst tandem cycloaddition green chem; naphthyridine preparation.

An efficient and facile iodine-catalyzed reaction of 2-amino carbonyls with β-enamino esters or β-enaminones afforded 1-azaxanthones, quinolines and naphthyridines in good to excellent yields. This novel catalytic [4+2] annulation reaction proceeded through a cascade I2-activation, Michael addition, intramol. aldol reaction and aromatization.

Asian Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, COA of Formula: C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Piao, Ming-Zhu; Imafuku, Kimiaki published the artcile< Friedlaender reaction of 3-acetyltropolones: synthesis of naphthyridinyl- and allied heterocyclic-substituted tropolones>, Application of C6H6N2O, the main research area is acetyltropolone Friedlaender reaction aminopyridinecarboxaldehyde; naphthyridinyl tropolone preparation; pyridopyrazinyl tropolone preparation; tropolone naphthyridinyl pyridopyrazinyl pyrazolopyridinyl preparation; pyrazolopyridinyl tropolone preparation.

The reaction of 3-acetyltropolones I (R1 = H, Me, Br, etc.; R2 = H, Br) with 2-amino-3-pyridinecarbaldehyde gave 3-(1,8-naphthyridin-2-yl)tropolones II (same R1, R2) in excellent yields. In a similar manner, 1,6-naphthyridin-2-yl, 1,7-naphthyridin-2-yl-, 6-pyrido[2,3-b]pyrazinyl-, and 1-methyl-6-pyrazolo[5,4-b]pyridyl-substituted tropolones were prepared Reactivities of amino-substituted heteroarenecarbaldehydes in these reactions and properties of the products were also discussed.

Journal of Heterocyclic Chemistry published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Application of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vikram, Venugopalarao; Amperayani, Karteek rao; Ummidi, Venkata Ravi Sankar; Parimi, Umadevi published the artcile< Synthesis, Anti-Microbial Activity, and Docking Studies of Novel N-Pyridine Substituted 2-Chlorothieno[2,3-d]pyrimidine Derivatives>, HPLC of Formula: 55279-29-3, the main research area is pyridine substituted chloro thienopyrimidinamine preparation antibacterial antifungal docking; acetyl coenzyme carboxylase inhibitor pyridine substituted chloro thienopyrimidinamine preparation.

A series of novel N-pyridine substituted 2-chloro-thieno[2,3-d]pyrimidin-4-amine derivatives I [Ar = 2-pyridyl, (3-methyl-2-pyridyl), (5-chloro-2-pyridyl), etc.] had been synthesized and characterized by 1H and 13C NMR spectrometry. All the compounds had been docked against acetyl-CoA carboxylase enzyme and also tested for their in vitro antimicrobial activity on Gram-pos. (Micrococcus luteus, staphylococcus aureus) and Gram-neg. bacteria (Salmonella typhi, klebsiella pneumoniae) and anti-fungal activity on aspergillus niger and fusarium oxysporum. All synthesized compounds have demonstrated moderate activity and two products have exhibited good antibacterial and antifungal activity.

Russian Journal of General Chemistry published new progress about Acetyl-coenzyme A carboxylase inhibitors. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, HPLC of Formula: 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Song, Jing-Ru; Li, Na; Li, Dian-Peng published the artcile< Synthesis and anti-proliferation activity of Mogrol derivatives bearing quinoline and triazole moieties>, Name: 3-Aminoisonicotinaldehyde, the main research area is Mogrol quinolinyl triazolyl synthesis antitumor agent; Lung cancer; Mogrol; Quinoline; Structural modification; Triazole.

A series of novel derivatives based on Mogrol were designed and synthesized in attempt to improve anti-lung cancer activity. The cytotoxicity against human lung cancer cells including A549 and NCI-H460 were performed by Cell Counting Kit-8 (CCK8) assay in vitro. The screening result showed that compound 8f exhibited the strongest activity with an IC50 value of 4.47μM against A549 cell, and could induce the cell apoptosis in a dose-dependent manner and arrest cell cycle at G0/G1 phase. Besides, compound 8f displayed anti-proliferation effect on A549 cell through inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3). Furthermore, compared with Mogrol, compound 10a significantly improved the cytotoxicity against NCI-H460 with the IC50 value of 17.13μM. The research stimulated the development of potential therapeutic agent for lung cancer from the natural Mogrol.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Name: 3-Aminoisonicotinaldehyde.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55279-29-3, 3-Aminoisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Example 3 [0159] 3-aminonicotinaldehyde (50 mg, 0.41 mmol) and 1 -(2-chloro-5- nitrophenyl)ethanone (82 mg, 0.41 mmol) were put into ethanol (1 ml_), and then added NaOH (0.3 mg, 0.01 mmol) at room temperature. The solution was heated to 70 C and stirred at this temperature for overnight. The reaction mixture was concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to yield the desired product (38 mg, 33 % yield) as a white solid. 1H NMR (400 MHz, DMSO-d6): delta 9.50 (s, 1 H), 8.71 (d, J = 5.2 Hz, 1 H), 8.63 (d, J = 8.4 Hz, 1 H), 8.53 (d, J = 2.8 Hz, 1 H), 8.40-8.37 (m, 1 H), 8.16 (d, J = 8.8 Hz, 1 H), 8.04-8.02 (m, 1 H), 7.99-7.97 (m, 1 H). MS (ESI): Calcd. for Ci4H8CIN3O2: 285, found 286 (M+H)+.

The synthetic route of 55279-29-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NANT HOLDINGS IP, LLC; TAO, Chunlin; YU, Chengzhi; ARP, Forrest; WEINGARTEN, Paul; SOON-SHIONG, Patrick; WO2014/71298; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55279-29-3, name is 3-Aminoisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-Aminoisonicotinaldehyde

tert-Butyl 4-({4-[(3-aminopyridin-4-yl)methyl]morpholin-2-yl}methyl)piperazine-1-carboxylate 3-Amino-pyridine-4-carbaldehyde (584 mg, 4.78 mmol) was dissolved in DCM (10 mL) and tert-butyl 4-(morpholin-2-ylmethyl)piperazine-1-carboxylate (1.50 g, 5.26 mmol) and NaBH(OAc)3 (1.11 g, 5.26 mmol) were added. The reaction mixture was heated in a microwave at 60 C. for 2.5 min, diluted with DCM (20 mL) and quenched with sat aq Na2CO3 (10 mL). The organic fraction was washed with sat aq NH4Cl (10 mL). The combined aq fractions were extracted with DCM (2*20 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the crude title compound as a yellow gum (2.46 g). LCMS (ES+): 392.1 [MH]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55279-29-3, 3-Aminoisonicotinaldehyde.

Reference:
Patent; PROXIMAGEN LIMITED; Carley, Allison; Simpson, Iain; US2014/275063; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55279-29-3, name is 3-Aminoisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 3-Aminoisonicotinaldehyde

tert-Butyl 4-({4-[(3-aminopyridin-4-yl)methyl]morpholin-2-yl}methyl)piperazine-1-carboxylate 3-Amino-pyridine-4-carbaldehyde (584 mg, 4.78 mmol) was dissolved in DCM (10 mL) and tert-butyl 4-(morpholin-2-ylmethyl)piperazine-1-carboxylate (1.50 g, 5.26 mmol) and NaBH(OAc)3 (1.11 g, 5.26 mmol) were added. The reaction mixture was heated in a microwave at 60 C. for 2.5 min, diluted with DCM (20 mL) and quenched with sat aq Na2CO3 (10 mL). The organic fraction was washed with sat aq NH4Cl (10 mL). The combined aq fractions were extracted with DCM (2*20 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the crude title compound as a yellow gum (2.46 g). LCMS (ES+): 392.1 [MH]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55279-29-3, 3-Aminoisonicotinaldehyde.

Reference:
Patent; PROXIMAGEN LIMITED; Carley, Allison; Simpson, Iain; US2014/275063; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55279-29-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55279-29-3, name is 3-Aminoisonicotinaldehyde, molecular formula is C6H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Amino-pyridine-4-carbaldehyde (5.00 g, 40.9 mmol) was dissolved in DCM (60 mL), ethyl 4-piperidinecarboxylate (7.57 mL, 49.1 mmol) and NaBH(OAc)3 (10.4 g, 49.1 mmol) were added and the reaction mixture was heated in a microwave reactor at 60 C. for 5 min. The reaction mixture was diluted with DCM (100 mL) and quenched with sat aq Na2CO3 (50 mL). The organic fraction was washed with sat aq NH4Cl (30 mL). The combined aq fractions were extracted with DCM (2*50 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the crude title compound as a yellow gum (11.3 g). LCMS (ES+): 264.1 [MH]+.

According to the analysis of related databases, 55279-29-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PROXIMAGEN LIMITED; Evans, David; Carley, Allison; Stewart, Alison; Higginbottom, Michael; Savory, Edward; Simpson, Iain; Nilsson, Marianne; Haraldsson, Martin; Nordling, Erik; Koolmeister, Tobias; US2014/357623; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem