Category: 55676-21-6

Related Products of 55676-21-6 ,Some common heterocyclic compound, 55676-21-6, molecular formula is C7H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 1-(2-chloropyridin-3-yl)ethanone (B-2) (6 g, 38.6 mmol) and hydrazine (85%, 9.1 g, 154.4 mmol) in pyridine (80 mL) was stirred under reflux overnight. The mixture was cooled to room temperature, concentrated, diluted with water (80 mL) and then extracted with ethyl acetate (100 mL*3). The combined organic layers were washed with brine, dried over Na2S04, and concentrated under vacuo. The resulting residue was used for the next step without furtuer purification. MS (m/z): 134 (M+1 )+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; WO2011/79804; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55676-21-6, Adding some certain compound to certain chemical reactions, such as: 55676-21-6, name is 1-(2-Chloropyridin-3-yl)ethanone,molecular formula is C7H6ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55676-21-6.

General procedure: 2-chloride pyridine derivatives (5mmol, 1.0eq), K2CO3 (7.5mmol, 1.5eq), 3-amino-1H-pyrazole-4-carbonitrile (5mmol, 1.0eq), CuI (0.5mmol, 0.1eq), ethylenediamine (1.0mmol, 0.2eq) were suspended in DMF. After three cycles of evacuating and backfilling with argon, the reaction tube was sealed and heated to 110°C for 20 hours. After cooling to room temperature, the mixture was diluted with water (100mL), and extracted with ethyl acetate (100mL×3). The organic phase was washed with water, brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified using silica gel chromatography to give the title compounds, yield 37-45percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fang, Zhen; Wang, Tian-qi; Li, Hui; Zhang, Guo; Wu, Xiao-ai; Yang, Li; Peng, Yu-lan; Zou, Jun; Li, Lin-li; Xiang, Rong; Yang, Sheng-yong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 14; (2017); p. 3201 – 3204;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55676-21-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55676-21-6, name is 1-(2-Chloropyridin-3-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 1-(2-chloropyridin-3-yl)ethanone (B-2) (6 g, 38.6 mmol) and hydrazine (85%, 9.1 g, 154.4 mmol) in pyridine (80 mL) was stirred under reflux overnight. The mixture was cooled to room temperature, concentrated, diluted with water (80 mL) and then extracted with ethyl acetate (100 mL*3). The combined organic layers were washed with brine, dried over Na2S04, and concentrated under vacuo. The resulting residue was used for the next step without furtuer purification. MS (m/z): 134 (M+1 )+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; JIA, Hong; DAI, Guangxiu; WO2011/79804; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55676-21-6, name is 1-(2-Chloropyridin-3-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H6ClNO

To a round bottom flask was added 1- (2-chloropyridin-3-yl) ethanone (96 g, 600 mmol)Aniline (72 g, 780 mmol) was dissolved in 1,4-dioxaneAnd then refluxed at 90 DEG C for 20 hours. After completion of the reaction, the residual aniline and the solvent were removed by distillation under reduced pressure.After removing the solvent, column purification (Hexane: MC = 1: 1)And then 88.8 g (yield 70percent) of 1- (2- (phenylamino) pyridin-3-yl) ethanone was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone.

Reference:
Patent; Jinung Industry Co., Ltd.; Kim Dong-hyeon; Lee Eung; Cho Eun-sang; Cho Hye-jin; Lee Ji-hwan; Han Sang-mi; Kim Dae-hwan; (37 pag.)KR2018/65486; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55676-21-6, blongs to pyridine-derivatives compound. Product Details of 55676-21-6

KOH (0.5 N MeOH, 6.0 mL, 3.0 mmol) was added to a solution of the compound 6 (467 mg, 3.0 mmol) prepared in Example 1 and 2-methoxybenzaldehyde (408 mg, 3.0 mmol) in THF The reaction was stopped by adding 0.5 N HCl (6 mL) to the mixed light yellow solution at 0 ° C and mixing at 0 ° C to room temperature for 3 hours. After evaporation of the solvent from this solution, the mixture was taken up in saturated NaHCO3 solution (30 mL) and extracted three times with dichloromethane (20 mL). The concentrated residue was purified by silica gel column chromatography using 30percent EtOAc / n-hexane as the extraction solvent to give compound 7l (673 mg, 82percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55676-21-6, its application will become more common.

Reference:
Patent; Duksung Women’s University Industry-Academic Cooperation Foundation; Jae, In Lee; (15 pag.)KR101766414; (2017); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem