Category: 55676-22-7

Electric Literature of 55676-22-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55676-22-7, name is 3-Acetyl-6-chloropyridine. A new synthetic method of this compound is introduced below.

2 g (11.57 mmol) of 1-(6-chloropyrid-3-yl)ethanone and 70 mL of ammonium hydroxide are placed in a Parr reactor. The solution is heated at 130 C. overnight. The mixture obtained is evaporated to dryness, and the residue is taken up in ethyl acetate and washed with water and with saturated NaCl solution. The organic phase is dried over sodium sulfate and evaporated to dryness to give 1.14 g of 1-(6-aminopyrid-3-yl)ethanone, the characteristics of which are as follows: LC/MS (method G): ESI+ [M+H]+: m/z 137 tr (min)=0.35 1H NMR (300 MHz, delta in ppm, CDCl3): 2.41 (s, 3H), 6.45 (d, 1H), 6.88 (s, 2H), 7.86 (d, 1H), 8.58 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55676-22-7, 3-Acetyl-6-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; El-Ahmad, Youssef; Filoche-Romme, Bruno; Ganzhorm, Axel; Marciniak, Gilbert; Muzet, Nicolas; Ronan, Baptiste; Vivet, Bertrand; Zerr, Veronique; US2015/183804; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55676-22-7, 3-Acetyl-6-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55676-22-7, blongs to pyridine-derivatives compound. HPLC of Formula: C7H6ClNO

To a stirring solution of 1-(6-chloro-pyridin-3-yl)-ethanone (l.Ommol, CAS No. 55676-22-7) and 4-methoxycarbonylphenyl boronic acid (1.2mmol) in dioxane (0.15M), add tetrakis- (triphenylphosphine) (0.044mmol) and 2M aqueous sodium carbonate (5.0mmol). Heat the reaction to 90C for three hours. After this time, remove the heat and concentrate in vacuo. Purify the title compound via radial chromatography eluting with methanol and dichloromethane. MS (m/e): 256.1 (M+l)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55676-22-7, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/97740; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 55676-22-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55676-22-7, name is 3-Acetyl-6-chloropyridine, molecular formula is C7H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Tert-butyl 4-((5-acetylpyridin-2-yl)oxy)piperidine-l-carboxylate (6) Tert-butyl 4- hydroxypiperidine-1-carboxylate (5) (1.4 g, 6.94 mmol) was added to a DMF suspension (10 mL) of 60% sodium hydride (0.25 g, 6.16 mmol) at 0C . The solution was stirred at room temperature for 0.5 h. At 0C, 1-(6-chloropyridin-3-yl)ethan-1-one (4) (0.9 g, 5.78 mmol) was added and the solution was stirred for 1 h. Water was added to the reaction solution, followed by extraction with EtOAc and subsequent sequential washing with water and saline and then the resulting organic layer was dried over Na2SO4. Silica gel column chromatography provided tert-butyl 4-((5-acetylpyridin-2- yl)oxy)piperidine-1-carboxylate (6) as a white solid. MS m/z321 [M+H]+.

According to the analysis of related databases, 55676-22-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ISOCURE BIOSCIENCES INC.; ZHANG, Tinghu; CHE, Jianwei; (96 pag.)WO2018/118793; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55676-22-7, 3-Acetyl-6-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 3-Acetyl-6-chloropyridine, blongs to pyridine-derivatives compound. Safety of 3-Acetyl-6-chloropyridine

To a solution of l-(6-chloropyridin-3-yl)ethanone (4.0 gm, 0.0257 mole) in DMF (15 mL), cesium carbonate (16.8 gm, 0.051 mole) was added followed by addition of methyl 2-hydroxyacetate (8.0 ml, 0.103 mmoles) at 25 C under nitrogen atmosphere and the reaction mixture was stirred at 80-90 C for 18 h. The reaction mixture was poured into ice cold water and extracted with ethyl acetate. The ethyl acetate extract was washed with water & brine, dried over sodium sulphate and evapourated under reduced pressure. The crude product was purified by colunm chromatography (Eluent: 16% ethyl acetate in hexane) to yield 1.25 gm (23%) of product as off white solid. NMR: DMSO-< 6,? 2.55 (s, 3H), 3.67 (s, 3H), 5.02 (s, 2H), 7.04 (dd, J = 8.8 & 0.4 Hz, 1H), 8.20 (dd, J= 8.8 & 2.4 Hz, 1H), 8.78 (d, J= 2.0 Hz, 1H). At the same time, in my other blogs, there are other synthetic methods of this type of compound,55676-22-7, 3-Acetyl-6-chloropyridine, and friends who are interested can also refer to it. Reference:
Patent; CADILA HEALTHCARE LIMITED; DESAI, Ranjit, C.; PINGALI, Harikishor; PANDYA, Vrajesh; MAKADIA, Pankaj; PATEL, Pankaj; WO2014/192023; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55676-22-7, name is 3-Acetyl-6-chloropyridine, molecular formula is C7H6ClNO, molecular weight is 155.5816, as common compound, the synthetic route is as follows.Product Details of 55676-22-7

To a 500 ml flask was added 6-chloro-3-acetylpyridine (18.7 g, 0.12 mol)P-cresol (14.26 g, 0.132 mol) and cesium carbonate (39 g, 0.12 mol)And DMF (300 ml) solvent.Heating reflux,After 1h, stop heating and cooling. The reaction solution was poured into excess water, stirred to precipitate a solid,filter. The crude product was recrystallized from ethyl acetate. Dried, weighed 16g, light yellow crystals, the yield was 58.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55676-22-7, 3-Acetyl-6-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; China Agricultural University; Tan Zhaohai; Yang Dongyan; (19 pag.)CN106946770; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55676-22-7, name is 3-Acetyl-6-chloropyridine, molecular formula is C7H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 3-Acetyl-6-chloropyridine

To a solution of 1-(6-chloropyridin-3-yl)ethanone (4.0 gm, 0.0257 mole) in DMF (15 mL), cesium carbonate (16.8 gm, 0.051 mole) was added followed by addition of methyl 2-hydroxyacetate (8.0 ml, 0.103 mmoles) at 25 C under nitrogen atmosphere and the reaction mixture was stirred at 80-90 C for 18 h. The reaction mixture was poured into ice cold water and extracted with ethyl acetate. The combined ethyl acetate extract was washed with water & brine, dried over sodium sulphate and evapourated under reduced pressure. The crude product was purified by colunm chromatography (Eluent: 16% ethyl acetate in hexane) to yield 1.25 gm (23%) of product as off white solid. 1H NMR: DMSO-d6, delta2.55 (s, 3H), 3.67 (s, 3H), 5.02 (s, 2H), 7.04 (dd, J = 8.8 & 0.4 Hz, 1H), 8.20 (dd, J = 8.8 & 2.4 Hz, 1H), 8.78 (d, J = 2.0 Hz, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 55676-22-7.

Reference:
Patent; Cadila Healthcare Limited; PINGALI, Harikishore; MAKADIA, Pankaj; PANDYA, Vrajesh; KALAPATAPU, V. V. M. Sairam; JAIN, Mukul R.; EP2658851; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 55676-22-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55676-22-7, name is 3-Acetyl-6-chloropyridine, molecular formula is C7H6ClNO, molecular weight is 155.5816, as common compound, the synthetic route is as follows.

To a mixture of 1-(6-chloro-pyridin-3-yl)-ethanone (0.50 g, 3.2 mmol), ferrocenecarboxaldehyde (0.69 g, 3.2 mmol), and lithium hydroxide (0.08 g, 3.2 mmol), in a 10 mL solution of water and ethanol (1/1), at room temperature, was applied an ultrasonic agitation for 10 seconds (amplitude = 0.3; ti = 29C, tf = 29C; E = 366 J). The tries of crystallization of the mixture did not provide any pure compound, thus, it was purified by flash chromatography (silica column, CH2Cl2:MeOH = 1:0 to 9:1) to give pure 1i (0.37 g, 1.1 mmol, 32.9% yield) as a dark red/purple solid. 1i: mp 209-211 C (EtOH); Rf (CH2Cl2:MeOH = 99:1) = 0.5; 1H NMR (DMSO[d6], 400 MHz) delta ppm 4.21 (s, 5H, ferrocenyl-H), 4.60 (s, 2H, ferrocenyl-H), 4.89 (s, 2H, ferrocenyl-H), 7.44 (d, J = 15.2 Hz, 1H, CHCHCO), 7.71 (d, J = 8.3 Hz, 1H, ArH), 7.74 (d, J = 15.2 Hz, 1H, CHCHCO), 8.43 (dd, J = 8.3, 2.6 Hz, 1H, ArH), 9.08 (d, J = 2.6 Hz, 1H, ArH); 13C NMR (CDCl3, 100 MHz) delta ppm 69.3 (2 CH ferrocenyl), 70.0 (5 CH ferrocenyl), 72.0 (2 CH ferrocenyl), 78.5 (C ferrocenyl), 117.9 (CH), 124.5 (CH), 132.8 (C), 138.5 (CH), 149.1 (CH), 149.7 (CH), 154.8 (C), 186.8 (C); IR nu (cm-1): 1652, 1584, 1363, 1312, 1095, 1015, 977, 748; Anal. Calcd for C18H14ClFeNO: C, 61.49; H, 4.01; N, 3.98. Found: C, 61.90; H, 4.12; N, 4.18%.

Statistics shows that 55676-22-7 is playing an increasingly important role. we look forward to future research findings about 3-Acetyl-6-chloropyridine.

Reference:
Article; Dubois, Joelle; Farce, Amaury; Ghinet, Alina; Homerin, Germain; Nica, Adrian Sorin; Bioorganic and medicinal chemistry letters; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem