Category: 55717-45-8

Synthetic Route of 55717-45-8, Adding some certain compound to certain chemical reactions, such as: 55717-45-8, name is 6-Bromopyridin-3-ol,molecular formula is C5H4BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55717-45-8.

2-Bromo-5-hydroxypyridine (5 mmol) is dissolved in DMF (10 ml) and NaH (1.4 eq., 60% suspension in liquid paraffin) is added. After 30 min iodomethane (2 eq.) is added and the reaction solution is stirred 3 days. The reaction solution is pored into water and extracted with methyl-tert-15 butyl ether. The combined organic layers are dried over MgSO4 and the solvent is removed in vacuo. 2-Bromo-5-methoxy-pyridine is obtained as yellow oil in a yield of 79 %; HPLC (method C): 1.49 min; LC-MS (method A): 1.16 min, 187.95 (M+H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55717-45-8, 6-Bromopyridin-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; WO2009/46784; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55717-45-8, name is 6-Bromopyridin-3-ol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C5H4BrNO

Reference Example 65 5-(benzyloxy)pyridine-2-carbaldehyde [Show Image] A solution of 6-bromopyridin-3-ol (4.20 g) in N,N-dimethylformamide (100 mL) was purged with nitrogen, sodium hydride (60%, oil, 1.06 g) was added under ice-cooling, and the mixture was stirred at 0C for 15 min. Benzyl bromide (3.15 mL) was added to the reaction mixture, and the mixture was warmed to room temperature, and stirred at room temperature for 16 hr. A saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane = 10:90 – 50:50, volume ratio) to give a colorless oil. A solution of the obtained oil in toluene (10 mL) was added to a solution of tributylmagnesium ate complex in toluene-tetrahydrofuran-hexane prepared from a 1.6M n-butyllithium hexane solution (8.4 mL) and a 2.0M butylmagnesium chloride tetrahydrofuran solution (3.4 mL) in at -10C, and the mixture was stirred at – 10C for 2.5 hr. N,N-dimethylformamide (1.59 mL) was added to the reaction mixture, and the mixture was warmed to room temperature and stirred at room temperature for 2 hr. 10% Aqueous citric acid solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane = 5:95 – 50:50, volume ratio) to give the title compound (1.00 g, yield 17%) as a colorless oil. MS:214(MH+).

The synthetic route of 55717-45-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2149550; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55717-45-8, name is 6-Bromopyridin-3-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Bromopyridin-3-ol

[000570] Synthesis [000571] A mixture of 2 (579 mg, 3.46 mmol), 1 (500 mg, 2.89 mmol) and K2C03 (1.2 mg, 8.7 mmol) in 5 mL of DMF was stirred at 60 C for 16 hours. The reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (40 mL x 3). The combined organic phases were washed with water (50 mL), brine (50 mL), dried over anhydrous Na2SC>4 and filtered. The filtration was concentrated in vacuo, and the residue was purified by silica gel chromatography (ethyl acetate: petroleum ether = 10: 1) to give 3 as white solid (650 mg, yield: 85.5%). LC-MS m/z: 266.0 [M+H]+. LC-MS Purity (254 nm): > 81%; tR= 1.964 min.

The synthetic route of 55717-45-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; ERB, Michael; QI, Jun; (96 pag.)WO2016/196879; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55717-45-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55717-45-8, name is 6-Bromopyridin-3-ol. A new synthetic method of this compound is introduced below.

Example 14a) 5-Benzyloxy-2-bromo-pyridineJTTo a solution of 10.0 g (57.47 mmol) of 2-bromo-5-hydroxypyridine in 400 mL DMF was added 14.75 g (86.21 mmol) of benzyl bromide and 23.82 g (172.4 mmol) of potassium carbonate. The mixture was stirred for 6 h at 600C and overnight at room temperature. The suspension was filtered off and after evaporation of the solvent the residue was chromatogra- phed on silica gel using a dichloromethane/methanol gradient. Yield: 14.82 g (96.7 %).MS (ESIpos): m/z = 264, 266 [M+H]+ 1H-NMR (300MHz, CHLOROFORM-d): delta [ppm]= 5.10 (s, 2H), 7.16 (dd, 1 H), 7.32 – 7.47 (m, 6H), 8.14 (d, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55717-45-8, its application will become more common.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; SCHMITT-WILLICH, Heribert; ROeHN, Ulrike; FRIEBE, Matthias; LEHMANN, Lutz; FITZNER, Ansgar; KRAUSE, Sabine; BROCKSCHNEIDER, Damian; DYRKS, Thomas; THIELE, Andreas; BOeMER, Ulf; MOeNNING, Ursula; HEINRICH, Tobias; WO2010/28776; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 55717-45-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55717-45-8, name is 6-Bromopyridin-3-ol, molecular formula is C5H4BrNO, molecular weight is 173.9954, as common compound, the synthetic route is as follows.

Compound (II-3) (5.00 g, 28.7 mmol) was dissolved in DMF (30 mL), potassium carbonate (7.94 g, 57.5 mmol),benzyl bromide (4.1 mL, 35 mmol) and TBAI (531 mg, 1.44 mmol) were added under ice-cooling, and the mixture waswarmed to room temperature and stirred for 1 hr. Water was added to the reaction mixture, and the mixture was extractedwith ethyl acetate. The organic layer was washed successively with water and saturated brine, dried over anhydroussodium sulfate, and filtered. The solvent was evaporated under reduced pressure. The residue was purified by silica gelcolumn chromatography (n-hexane:ethyl acetate = 97:3 ?80:20) to give compound (M-16) (yield 6.97 g, 92%) as awhite solid

Statistics shows that 55717-45-8 is playing an increasingly important role. we look forward to future research findings about 6-Bromopyridin-3-ol.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55717-45-8 ,Some common heterocyclic compound, 55717-45-8, molecular formula is C5H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of benzylbromide (3.24g, 18.97mmol), 6-bromopyridin-3-ol (3g, 17.24mmol) and cesium carbonate (8.43 g, 25.90 mmol) in dry acetonitrile (50 mL) was stirred overnight at room temperature. After the completion of the reaction, the reaction mixture was diluted with ethyl acetate (80 mL) and filtered. The filtrate was concentrated under vacuum to afford the title compound (4.05 g). Yield: 89% JH NMR (300 MHz, CDCI3): delta 8.15 (s, 1H), 7.42-7.37 (m, 5H), 7.19-7.15 (m, 1H), 5.11 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55717-45-8, 6-Bromopyridin-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; KUMAR, Sanjay; SHARMA, Rajiv; DEORE, Vijaykumar, Bhagwan; YEWALKAR, Nilambari Nilkanth; (119 pag.)WO2016/12965; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem