Adding a certain compound to certain chemical reactions, such as: 55934-01-5, 2,4,5-Trichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2,4,5-Trichloropyridine, blongs to pyridine-derivatives compound. Application In Synthesis of 2,4,5-Trichloropyridine
To a solution of 2,4,5-trichloropyridine (5 g, 27.4 mmol) in 150 ml of THF was added LDA (2 M in heptane, 20.56 ml, 41.1 mmol) at -78 C. The mixture was stirred at -78 C. for 1 hour. Then methyl formate (8.23 g, 137 mmol) in THF (20 mL) was added quickly into the reaction mixture followed by stirring at -78 C. for 1 hour. The reaction mixture was quenched with aqueous saturated NH4Cl solution and extracted with EtOAc three times. The combined organic layers were dried over anhydrous Na2SO4 and, volatiles were removed under reduced pressure. The residue was purified with silica-gel chromatography (10-100% EtOAc in heptane) to afford the desired compound as a solid (4.2 g, 73%). ESI-MS m/z: 211.8 [M+H]+ (Rt=0.86 min, LC-method 1), 1H NMR (400 MHz, DCM-d2) delta ppm=10.43 (s, 1H), 8.61 (s, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55934-01-5, 2,4,5-Trichloropyridine, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; BARBE, Guillaume; BEBERNITZ, Gregory Raymond; GENG, Sicong; GULGEZE EFTHYMIOU, Hatice Belgin; LIAO, Lv; MA, Fupeng; MO, Ruowei; PARKER, David Thomas; PENG, Yunshan; PEUKERT, Stefan; YAMADA, Ken; YASOSHIMA, Kayo; (78 pag.)US2018/111932; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem