Category: 56026-36-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H9NO3

Dess-Martin reagent (207 mg, 0.49 mmol) was added to a stirring solution of 6- hydroxymethyl-nicotinic acid methyl ester (55 mg, 0.33 mmol) in DCM (17 mL). After stirring for 3 h the solvent was removed in vacuo. The residue was purified by flash chromatography on silica gel (elution with n-hexane/EA 4:1) to give the title compound.GCMS (m/z): 165.2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 56026-36-9, Methyl 6-(hydroxymethyl)nicotinate.

Reference:
Patent; JERINI AG; WO2009/36996; (2009); A2;,
Pyridine – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Methyl 6-(hydroxymethyl)nicotinate

Step 1.; Preparation of methyl 6-((methylsulfonyloxy)methyl)nicotinate; [0121] A Catalytic amount of DMPA (dimethylol propionic acid), triethylamine (2.Og, 19.7mmol) in 20 mL CH2C12, and methanesulfonyl chloride (1.95g, 17.0mmol) are added dropwise to a solution of 6-hydroxymethyl-nicotinic methyl ester 6 (2.2g, 13.1mmol), at -78C under argon. The mixture is stirred for 5 hours at -78C and then quenched with 30 mL saturated aqueous sodium bicarbonate. The organic layer is collected and the water phase extracted with CH2C12 (2x30mL). The organic phases are combined and washed with water. The CH2C12 solution is dried over MgSO4 and concentrated to give compound 7, which is used without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 56026-36-9, Methyl 6-(hydroxymethyl)nicotinate.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WO2006/122011; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56026-36-9, Methyl 6-(hydroxymethyl)nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56026-36-9, blongs to pyridine-derivatives compound. Recommanded Product: Methyl 6-(hydroxymethyl)nicotinate

A solution of compound 9 (2.5 g, 14.96 mmol) in 25 DMF (10 mL) was treated with 26 imidazole (1.527 g, 22.43 mmol) and 27 t-butyldimethylsilyl chloride (TBS-Cl, 2.480 g, 16.45 mmol). After 2 h, LCMS showed completion of reaction. The reaction was washed with sat. aq. NaHCO3 and brine, and the organic layer was dried over Na2SO4. The crude 28 methyl 6-(((tert-butyldimethylsilyl)oxy)methyl)nicotinate (93% yield) was taken to next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56026-36-9, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; POUDEL, Yam B.; He, Liqi; Gangwar, Sanjeev; Posy, Shoshana L.; Sivaprakasam, Prasanna; (38 pag.)US2019/55245; (2019); A1;,
Pyridine – Wikipedia,
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Related Products of 56026-36-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate. A new synthetic method of this compound is introduced below.

To a methanol (16 mL)-acetic acid (20 mL) solution of methyl 6-hydroxymethylnicotinate (1.16 g, 6.94 mmol), 10% palladium/carbon (580 mg) was added. Then, the reaction solution was stirred for 12 hours at room temperature under a 4 atmospheres (0.4 MPa)-hydrogen atmosphere, the reaction solution was filtered with Celite. The solvents of the filtrate were removed under reduced pressure to give desired piperidine derivative. The product was used for the following reaction without further purification. In a 200 mL recovery flask, to an acetonitrile (46 mL) solution of the piperidine derivative obtained in the reaction described above, a 37% formalin aqueous solution (1.24 mL) and sodium triactoborohydride (3.97 g, 18.7 mmol) were added. The reaction mixture was stirred for 30 minutes at room temperature. After adding 20% potassium carbonate aqueous solution 20 mL, the product was extracted with chloroform/methanol solution (9/1, 50 mL) six times. The combined organic layer was dried with sodium sulfate, and the solvents were removed under reduced pressure. The residue was purified with aminosilica gel column chromatography (chloroform/methanol=9/1) to give crystalline methyl 6-hydroxymethyl-1-methypiperidine-3-carboxylate (1.02 g; total yield of two steps, 79%). (0449) LCMS (M+H=188)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56026-36-9, its application will become more common.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; SUMITOMO DAINIPPON PHARMA CO., LTD.; FUSANO, Akira; KOBAYASHI, Tomonori; SAITO, Yasuhiro; KANAI, Toshio; (55 pag.)US2016/221948; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate, molecular formula is C8H9NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of Methyl 6-(hydroxymethyl)nicotinate

A mixture of methyl 6-(hydroxymethyl)nicotinate (7 g , 37 mmol) and Mn02 (32,3 g , 372 mmol) in DCM ( 200 mL ) was stirred at 20 C for 4 hours. The mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography on silica gel (PE/EtOAc = 5/1) to afford methyl 6-formylnicotinate (6 g , 97%).MS-ESI (m/z): 166.2 (M+l) + (LC-MS method C; Ret. time: 0.36 min).

With the rapid development of chemical substances, we look forward to future research findings about 56026-36-9.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Hao; KIM, Ronald M.; LIU, Jian; GAO, Xiaolei; BOGA, Sobhana Babu; GUIADEEN, Deodialsingh; KOZLOWSKI, Joseph; YU, Wensheng; ANAND, Rajan; YU, Younong; SELYUTIN, Oleg B.; GAO, Ying-Duo; LIU, Shilan; YANG, Chundao; WANG, Hongjian; WO2014/114185; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate, the common compound, a new synthetic route is introduced below. Application In Synthesis of Methyl 6-(hydroxymethyl)nicotinate

A mixture of methyl 6-(hydroxymethyl)nicotinate (250 mg, 1.496 mmol) and thionyl chloride (1 mL, 13.70 mmol) in dichloromethane (2 mL) was stirred at 45 C for 3 hrs and concentrated under reduced pressure. The residue was taken up indichloromethane (25 mL), sonicated and concentrated under reduced pressure. This was repeated three times and the residue was dried in high vacuo providing of methyl 6- (chloromethyl)nicotinate (266 mg), which was used in the next reaction without further purification. LCMS (m/z): 186.0 [M+H]+; Rt = 0.63 min.

The synthetic route of 56026-36-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; NG, Simon C.; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James; WO2012/101063; (2012); A1;,
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Pyridine | C5H5N – PubChem

Synthetic Route of 56026-36-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.

Dess-Martin periodinane (3.0 g, 7.2 mmol) was added slowly to the mixture of compound 38 (1.0 g,6.0 mmol) in DCM (10 mL). The resulting mixture continued to stir at room temperature overnight.The reaction was quenched with water. The aqueous phase was extracted with EtOAc. The combinedorganic phases were then processed in the usual way and chromatographed (3:1 petroleum ether/EtOAc)to yield compound 39 (0.85 g, 86%).

The chemical industry reduces the impact on the environment during synthesis 56026-36-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Wang, Wen-Long; Yang, Dong-Lin; Gao, Li-Xin; Tang, Chun-Lan; Ma, Wei-Ping; Ye, Hui-Hua; Zhang, Si-Qi; Zhao, Ya-Nan; Xu, Hao-Jie; Hu, Zhao; Chen, Xia; Fan, Wen-Hua; Chen, Hai-Jun; Li, Jing-Ya; Nan, Fa-Jun; Li, Jia; Feng, Bainian; Molecules; vol. 19; 1; (2014); p. 102 – 121;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 56026-36-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.

Dissolving methyl 6-(hydroxymethyl)nicotinate in DCM (10 mL).Cool to 0 C,Triethylamine (2.43 g, 12 mmol) was added in sequenceAnd methanesulfonyl chloride (2.06 g, 18 mmol),Slowly warm to room temperature and react overnight.TLC monitors the reaction completely,Add saturated aqueous ammonium chloride solution (5 mL),Liquid separation,The aqueous phase was extracted with DCM (3¡Á10 mL).Combine the organic phase,Washed (2 ¡Á 5mL),Dry over anhydrous sodium sulfate,filter,Concentrated6-((((methylsulfonyl)oxy)methyl)methyl nicotinate(3.2g crude).

The chemical industry reduces the impact on the environment during synthesis 56026-36-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56026-36-9, Methyl 6-(hydroxymethyl)nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56026-36-9, blongs to pyridine-derivatives compound. Product Details of 56026-36-9

6-hydroxymethyl nicotinic acid methyl ester (11 ) (10.0 g, 59.8 mmol) was azeotroped with acetonitrile ( 2 x 100 mL) then dissolved in (0261) dichloromethane (alcohol free, 150 mL) and treated with (0262) diisopropylethylamine (12.5 mL, 71 .8 mmol) followed by 2-cyanoethyl-N,N- diisopropylchlorophosphoramidite (13.4g, 56.8 mmol). The reaction mixture was stirred at RT, under argon for 1 .5 hours. TLC (1 : 1 hexane: EtOAc, visualised by PMA/heat) showed reaction completion (SM Rf ~ 0.3, prod Rf ~ 0.5). (0263) The mixture was washed with sat. NaHC03(aq) (100 mL) and the layers were separated. The organic phase was washed with 100 mL sat. then dried over anhydrous sodium sulphate, filtered and concentrated in vacuo to give a brown oil. This was triturated with pentane (2 x 150 mL). (0264) The crude material was purified by flash column chromatography on pre- equilibrated silica gel (1 : 1 EtOAc : pentane + 1 % NEt3) eluting with 1 : 1 EtOAc : pentane, the crude product was loaded in DCM. Product containing fractions were selected by TLC and concentrated in vacuo to give a colourless oil. This was azeotroped with MeCN and dried on the freeze-drier overnight to give 12 (6.55g, 30%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56026-36-9, its application will become more common.

Reference:
Patent; LINK TECHNOLOGIES LIMITED; MCGEOCH, Grant; MCKEEN, Catherine; OSNOWSKI, Andrew; WILSON, Jennifer; WO2015/132577; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 56026-36-9, Adding some certain compound to certain chemical reactions, such as: 56026-36-9, name is Methyl 6-(hydroxymethyl)nicotinate,molecular formula is C8H9NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56026-36-9.

A mixture of methyl 6-(hydroxymethyl)nicotinate (7 g , 37 mmol) and Mn02 (32,3 g , 372 mmol) in DCM ( 200 mL ) was stirred at 20 C for 4 hours. The mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography on silica gel (PE/EtOAc = 5/1) to afford methyl 6-formylnicotinate (6 g , 97%).MS-ESI (m/z): 166.2 (M+l) + (LC-MS method C; Ret. time: 0.36 min).

According to the analysis of related databases, 56026-36-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Hao; KIM, Ronald M.; LIU, Jian; GAO, Xiaolei; BOGA, Sobhana Babu; GUIADEEN, Deodialsingh; KOZLOWSKI, Joseph; YU, Wensheng; ANAND, Rajan; YU, Younong; SELYUTIN, Oleg B.; GAO, Ying-Duo; LIU, Shilan; YANG, Chundao; WANG, Hongjian; WO2014/114185; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem