Category: 5654-95-5

Synthetic Route of 5654-95-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5654-95-5, name is 1H-Pyrrolo[2,3-b]pyridine-2,3-dione, molecular formula is C7H4N2O2, molecular weight is 148.1189, as common compound, the synthetic route is as follows.

To a THF solution of E1 and RI-Br (R1 = alpha-methyl-p-fluorobenzyl) will be added NaH (1.1 eq) and the solution will be heated until the starting material disappears. After removal of volatiles, the residue will be chromatographed to give compound E2.

Statistics shows that 5654-95-5 is playing an increasingly important role. we look forward to future research findings about 1H-Pyrrolo[2,3-b]pyridine-2,3-dione.

Reference:
Patent; SCHERING CORPORATION; WO2009/20580; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 5654-95-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5654-95-5, name is 1H-Pyrrolo[2,3-b]pyridine-2,3-dione. This compound has unique chemical properties. The synthetic route is as follows.

Method 1: Under argon atmosphere at 90 C, a solution of thallium(III) acetate (1.91 g, 5 mmol) in glacial acetic acid (25 mL) was added dropwise within 2 h to a solution of 1 (1.075 g, 9.1 mmol) in glacial acetic acid (7.5 mL). The mixture was stirred overnight at 90 C, cooled with ice and the solvent was removed by evaporation. The residue was extracted with ethyl acetate, filtered and the product was purified by repeated crystallization from ethyl acetate (red violet crystals, yield: 130 mg, 10.9%).Method 2: Acid condensation. 7-Azaisatin (67.1 mg, 0.45 mmol) and 7-azaindoxyl-3-acetate (70 mg, 0.4 mmol) were suspended under argon atmosphere in acetic acid (4 mL) and conc. HCl (340 muL). The mixture was stirred at room temperature for overnight and diluted with water (30 ml). The precipitate was filtrated and purified by recrystallization from 1 N HCl/EtOH (75 mg, 0.28 mmol, 62.2%).1H NMR (400 MHz, DMSO-d6, delta = 2.49 ppm): 11.58 (s, 1H), 10,74 (s, 1H), 8.84 (dd, 1H, 3JH,H = 7.9 Hz, 4JH,H = 1.7 Hz), 8.50 (dd, 1H, 3JH,H = 4.8 Hz, 4JH,H = 1.7 Hz), 8.15-8.11 (m, 2H), 7.15-7.07 (m, 2H). 13C-{1H} NMR (150 MHz, DMSO-d6, delta = 39.5 ppm): 186.3, 170.5, 163.4, 155.8, 155.4, 147.8, 138.7, 133.8, 131.5, 118.2, 117.9, 115.5, 112.9, 105.7. C14H8N4O2¡¤0.67 H2O. Found: C 60.89, H 3.35, N 19.85; requires: C 60.87, H 3.41, N 20.28.

According to the analysis of related databases, 5654-95-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cheng, Xinlai; Merz, Karl-Heinz; Vatter, Sandra; Christ, Jochen; Woelfl, Stefan; Eisenbrand, Gerhard; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 247 – 255;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem