Category: 56673-34-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 56673-34-8, name is 3-Bromo-6-mercaptopyridine. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Bromo-6-mercaptopyridine

General procedure: To a mixture of thiol (0.35mmol) in iPrOH in a 10mL vial, Rose Bengal (0.05equiv) were added and the reaction mixture was stirred at room temperature under white LED irradiation. The reaction mixture was quenched by addition of saturated aqueous NaOH (10mL), extracted with Et2O (3×10mL), dried over Na2SO4 and evaporated under reduced pressure to give the desired product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 56673-34-8, 3-Bromo-6-mercaptopyridine.

Reference:
Article; Tankam, Theeranon; Poochampa, Kamolrut; Vilaivan, Tirayut; Sukwattanasinitt, Mongkol; Wacharasindhu, Sumrit; Tetrahedron; vol. 72; 6; (2016); p. 788 – 793;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56673-34-8, 3-Bromo-6-mercaptopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Bromo-6-mercaptopyridine, blongs to pyridine-derivatives compound. name: 3-Bromo-6-mercaptopyridine

To a solution of NaOH (7.67 g, 192 mmol) in water (600 mL) was added Example 739A (32 g, 167 mmol) at 20 C under N2, and the mixture was stirred for 30 minutes. A solution of potassium hexacyanoferrate (III) (63.1 g, 192 mmol) in water (500 mL) was added dropwise to the mixture. The resulting reaction mixture was stirred for 14 hours at 20 C. The precipitate was collected by filtration, washed by water and dried by high vacuum to provide the title compound (29 g, yield 88%).JH NMR: (400 MHz, DMSO-

The synthetic route of 56673-34-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; BROWN, Brian, S.; MURAUSKI, Kathleen; (673 pag.)WO2019/90069; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 56673-34-8, Adding some certain compound to certain chemical reactions, such as: 56673-34-8, name is 3-Bromo-6-mercaptopyridine,molecular formula is C5H4BrNS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56673-34-8.

To a solution of 5-bromopyridine-2-thiol (3.9 g) in THF (100 ml_) was added NaH (1 .24 g) at 0C and the mixture was stirred at 0C for 0.5 h. Then (bromomethyl)cyclopropane (2.79 g) was added. The mixture was allowed to warm to r.t. and stirred for 6 hours. Themixture was poured into ice water (200 ml_) and extracted with EA (100 ml_ x 3). The combined organic phases were washed with brine (50 ml_) and then dried over Na2SO4. After filtration and evaporation of the solvent, the residue was purified by SGC (eluent: PE) to provide the subtitle compound. MS ESI+: m/z = 244 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56673-34-8, 3-Bromo-6-mercaptopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; WO2014/56938; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56673-34-8, 3-Bromo-6-mercaptopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Bromo-6-mercaptopyridine, blongs to pyridine-derivatives compound. name: 3-Bromo-6-mercaptopyridine

To a solution of NaOH (7.67 g, 192 mmol) in water (600 mL) was added Example 739A (32 g, 167 mmol) at 20 C under N2, and the mixture was stirred for 30 minutes. A solution of potassium hexacyanoferrate (III) (63.1 g, 192 mmol) in water (500 mL) was added dropwise to the mixture. The resulting reaction mixture was stirred for 14 hours at 20 C. The precipitate was collected by filtration, washed by water and dried by high vacuum to provide the title compound (29 g, yield 88%).JH NMR: (400 MHz, DMSO-

The synthetic route of 56673-34-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; PLIUSHCHEV, Marina, A.; FROST, Jennifer, M.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; XIONG, Zhaoming; SWEIS, Ramzi, Farah; DART, Michael, J.; BROWN, Brian, S.; MURAUSKI, Kathleen; (673 pag.)WO2019/90069; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 56673-34-8, Adding some certain compound to certain chemical reactions, such as: 56673-34-8, name is 3-Bromo-6-mercaptopyridine,molecular formula is C5H4BrNS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56673-34-8.

To a solution of 5-bromopyridine-2-thiol (3.9 g) in THF (100 ml_) was added NaH (1 .24 g) at 0C and the mixture was stirred at 0C for 0.5 h. Then (bromomethyl)cyclopropane (2.79 g) was added. The mixture was allowed to warm to r.t. and stirred for 6 hours. Themixture was poured into ice water (200 ml_) and extracted with EA (100 ml_ x 3). The combined organic phases were washed with brine (50 ml_) and then dried over Na2SO4. After filtration and evaporation of the solvent, the residue was purified by SGC (eluent: PE) to provide the subtitle compound. MS ESI+: m/z = 244 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56673-34-8, 3-Bromo-6-mercaptopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried; WO2014/56938; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56673-34-8, 3-Bromo-6-mercaptopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 56673-34-8, blongs to pyridine-derivatives compound. SDS of cas: 56673-34-8

2.0 g of 5-Bromo-pyridine-2-thiol (compound C1 ) are dissolved in 40 ml of carbon tetrachloride and 8 ml of water. Subsequently, the suspension is cooled in an ice bath and chlorine gas is passed into the reaction mixture for 20 min (flow: 35 ml/min). Thereafter, nitrogen is passed into the yellow solution to remove excess chlorine. Subsequently, the mixture is diluted with 150 ml of dichloromethane and extracted with 50 ml of brine. The organic layer is separated, dried using Na2SO4, filtered with suction, and evaporated to dryness to afford 2.70 g of the title compound as light yellow needles. M. p. 8O0C. GC-MS: 254.8/256.8/258.8 (77:100:25; M+). TLC: Rf = 0.84 (dichloromethane/ethanol 20:1 parts by volume).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56673-34-8, 3-Bromo-6-mercaptopyridine, and friends who are interested can also refer to it.

Reference:
Patent; ALTANA PHARMA AG; WO2007/39580; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56673-34-8, name is 3-Bromo-6-mercaptopyridine, molecular formula is C5H4BrNS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C5H4BrNS

A suspension of 5-bromo-pyridine-2-thiol (which may be prepared as described for Intermediate 1.05; 2 g, 10.5 mmol) in carbon tetrachloride (40 mL) and water (8 mL) was cooled to 0 C. using an ice-bath. Chlorine gas was bubbled through the reaction mixture for 20 min and then CH2Cl2 (100 mL) was added. The mixture was washed with brine. The organic layer was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure to give 5-bromo-pyridine-2-sulfonyl chloride (1.92 g, 71%) as a light yellow solid which was used directly in the next step without further purification. NMR (400 MHz, DMSO-d6) delta: 8.63 (d, J=1.5 Hz, 3H), 8.07 (dd, J=8.3, 2.2 Hz, 3H), 7.68 (d, J=8.3 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 56673-34-8.

Reference:
Patent; Firooznia, Fariborz; Gillespie, Paul; Lin, Tai-An; So, Sung-Sau; US2012/309796; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56673-34-8, 3-Bromo-6-mercaptopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Bromo-6-mercaptopyridine, blongs to pyridine-derivatives compound. name: 3-Bromo-6-mercaptopyridine

Powdered sodium methoxide (1.08 g, 19.95 mmol) and 1-bromo-3-chloropropane (2.87 mL, 28.7 mmol) were added to a stirred suspension of 5-bromopyridine-2-thiol (3.16 g, 16.63 mmol) in anhydrous methanol (80 mL). The mixture was heated at 60C and stirred under N2 for 1.5 h. After cooling to room temperature, the mixture wasquenched with water-brine (1:1, 100 mL) and extracted with EtOAc (2 x 100 mL). The combined organic fraction was washed with brine (50 mL), then dried (MgSO4) and reduced in vacuo, to give the title compound (3.92 g, 88%) as a yellow solid. H (500 MHz, CDC13) 8.50-8.44 (m, 1H), 7.58 (dd,J8.5, 2.4 Hz, 1H), 7.07 (dd,J8.5, 0.6 Hz, 1H), 3.67 (t,J6.4 Hz, 2H), 3.29 (t,J6.9 Hz, 2H), 2.17 (p,J6.6 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56673-34-8, 3-Bromo-6-mercaptopyridine, and friends who are interested can also refer to it.

Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; BENTLEY, Jonathan Mark; BRACE, Gareth Neil; BROOKINGS, Daniel Christopher; CHOVATIA, Praful Tulshi; DEBOVES, Herve Jean Claude; JOHNSTONE, Craig; JONES, Elizabeth Pearl; KROEPLIEN, Boris; LECOMTE, Fabien Claude; MADDEN, James; MILLER, Craig Adrian; PORTER, John Robert; SELBY, Matthew Duncan; SHAW, Michael Alan; VAIDYA, Darshan Gunvant; YULE, Ian Andrew; WO2015/86506; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 56673-34-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56673-34-8, name is 3-Bromo-6-mercaptopyridine, molecular formula is C5H4BrNS, molecular weight is 190.06, as common compound, the synthetic route is as follows.

Weigh 0.591 g of Nd (OTf) 3, 0.33 g of tetraacetylated fucose,0.19 g of 5-bromo-2-mercaptopyridine in a parallel reaction tube. Nitrogen atmosphere were added 10mL1,2-dichloroethane, ionic liquid PFIL-2 [R1, R2, R3 = phenyl,n = 4, X = (CF3SO2) 2N] 0.5mL, the reaction tube was sealed, the reaction was stirred,Microwave irradiation using intermittent, power 500W,Each irradiation for 5 minutes, stop irradiation for 1 minute. Reaction for 5 hours,Temperature control at 80 degrees Celsius. The reaction was terminated by adding water.Separation by silica gel column gave 0.336 g of glycoside 1 in 73% yield.Ionic liquids can be reused, no significant change in yield.

Statistics shows that 56673-34-8 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-6-mercaptopyridine.

Reference:
Patent; Ningbo University; Chen Weiting; (9 pag.)CN106397507; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56673-34-8, name is 3-Bromo-6-mercaptopyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 3-Bromo-6-mercaptopyridine

B8. 5-Bromo-pyridine-2-sulfonyl chloride; 2.0 g of 5-bromo-pyridine-2-thiol (compound C2) are dissolved in 40 ml of carbon tetrachloride and 8 ml of water. Subsequently, the suspension is cooled in an ice bath and chlorine gas is passed into the reaction mixture for 20 min (flow: 35 ml/min). Thereafter, nitrogen is passed into the yellow solution to remove excess chlorine. Subsequently, the mixture is diluted with 150 ml of dichloromethane and extracted with 50 ml of brine. The organic layer is separated, dried using Na2SO4, filtered with suction, and evaporated to dryness to afford 2.70 g of the title compound as light yellow needles. M. p. 8O0C. GC-MS: 254.8/256.8/258.8 (77:100:25; M+). TLC: Rf = 0.84 (dichloromethane/ethanol 20:1 parts by volume).

The synthetic route of 56673-34-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALTANA Pharma AG; WO2007/39578; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem