56809-84-8 | Pyridine-derivatives

Delarge, J. et al. published their research in Pharmaceutica Acta Helvetiae in 1975 | CAS: 56809-84-8

3,4-Dichloro-5-nitropyridine (cas: 56809-84-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C5H2Cl2N2O2

Syntheses using 4-hydroxy-3-nitropyridine. Antimicrobial and antiviral activity was written by Delarge, J.;Lapiere, C. L.. And the article was included in Pharmaceutica Acta Helvetiae in 1975.Computed Properties of C5H2Cl2N2O2 This article mentions the following:

Anilinopyridines I (R = H, Cl; R1 = H, halo, CF3, NO2, OH, Me, OMe, SH; R2 = H, Cl, F, NO2, OH, SO3H, SO2NH2, Me; R3 = H, Me, Cl) (42 compounds) were prepared by treating 4-chloropyridines with dianilines. I had slight bactericidal and virucidal activity. In the experiment, the researchers used many compounds, for example, 3,4-Dichloro-5-nitropyridine (cas: 56809-84-8Computed Properties of C5H2Cl2N2O2).

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sep-21 News Analyzing the synthesis route of 56809-84-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56809-84-8, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 56809-84-8, 3,4-Dichloro-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56809-84-8, blongs to pyridine-derivatives compound. Formula: C5H2Cl2N2O2

To a solution of intermediate 18-b (25 g 125.94 mmol) in ethanol (250 mL) was added cyclopropylamine (11.10 g, 194.31 mmol). The solution was warmed to 80C for 1 hour. The solvent was evaporated and water was added. The resulting mixture was extracted with dichloromethane (3×50 mL). The organic layer was washed with brine, dried with MgSC^ and concentrated. The intermediate 18-c was obtained (26 g, 94%>).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56809-84-8, its application will become more common.

Reference:
Patent; JANSSEN R&D IRELAND; TAHRI, Abdellah; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; VENDEVILLE, Sandrine Marie Helene; HU, Lili; WO2013/186335; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: 56809-84-8

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56809-84-8, 3,4-Dichloro-5-nitropyridine, and friends who are interested can also refer to it.

Application of 56809-84-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56809-84-8, name is 3,4-Dichloro-5-nitropyridine. A new synthetic method of this compound is introduced below.

To a solution of NaH (60% in mineral oil, 1.33 g, 33.42 mmol) in DMF (40 mL) at 0 C was added dropwise tert-butyl methyl malonate (5.65 mL, 33.42 mmol) in DMF (10 mL). The mixture was stirred at ft for 30 mm., then 3,4-dichloro-5-nitropyridmne (commercial, 4.3 g, 22.28 mmol) in DMF (10 mL) was added dropwise at 0 C. The reaction mixture was stirred at rt for 6 h, then acidified to pH 3 with a 2N aqueous solution of HCI. The reaction mixture was poured onto ice water and the compound was extracted in Et20. The organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure. The residue waspurified by column chromatography using 20% EtOAc in hexanes to afford 3.83 g of tertbutyl methyl (3-chloro-5-nitropyridin-4-yl)propanedioate a4 as pale yellow solid.Yield: 52%.1H NMR (400 MHz, CDCI3) 6 9.15 (s, 1H), 8.88 (s, 1H), 5.37 – 5.51 (m, 1H), 3.79 (s, 3H),1.46 (s, 9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56809-84-8, 3,4-Dichloro-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; UCB BIOPHARMA SPRL; SKOLC, David; ATES, Ali; JNOFF, Eric; VALADE, Anne; (99 pag.)WO2016/55482; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: Synthetic Route of 56809-84-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56809-84-8, 3,4-Dichloro-5-nitropyridine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 56809-84-8 ,Some common heterocyclic compound, 56809-84-8, molecular formula is C5H2Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of tert-butyl 4-aminopiperidine-1-carboxylate (4.47 g, 22.39 mmol) in DMF (60 mL) were added DIPEA (4.68 mL, 26.87 mmol) and 3,4-dichloro-5-nitropyridine (4.3 g, 22.39 mmol) and the resulting reaction mixture was stirred at 80 C for 16 h. The reaction mixture was cooled to room temperature and diluted with chilled water and the organic components were extracted in EtOAc. The organic layer was washed water, brine and dried over anhyd. Na2504. The organic layer was then concentrated in vacuo to obtain crude product as dark brown oil. The crude material was purified by silica gel (100-200 mesh) column chromatography using 20% EtOAc/Hexane as eluent to afford the title compound (2 g, 25%) as a solid.

Reference:
Patent; MEDIVIR AB; AYESA, Susana; ERSMARK, Karolina; KALAYANOV, Gennadiy; LEIJONMARCK, Marie; SALVADOR ODEN, Lourdes; WESTERLIND, Hans; WAeHLING, Horst; BERTRAND, Megan; BROCHU, Christian; GHIRO, Elise; KUHN, Cyrille; STURINO, Claudio; BYLUND, Johan; SEHGELMEBLE, Fernando; (215 pag.)WO2017/18924; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem