Category: 571189-49-6

Reference of 571189-49-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 571189-49-6, name is 5-(4-Methylpiperazin-1-yl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

5-(6-[[5-(4-methylpiperazin-l-yl)pyridin-2-yl]amino]pyrimidin-4-yl)-2-(oxan-4- yloxy)benzonitrile: 5-(6-[[5-(4-methylpiperazin- l-yl)pyridin-2-yl]amino]pyrimidin-4-yl)-2- (oxan-4-yloxy)benzonitrile was prepared from 5-(6-chloropyrimidin-4-yl)-2-(oxan-4- yloxy)benzonitrile and 5-(4-methylpiperazin-l-yl)pyridin-2-amine using Method 28. The final product was purified by prep-HPLC under the following conditions: column, XB ridge Prep C18 OBD Column, 150 x 19 mm, 5 um; mobile phase, acetonitrile in water (with 0.05% NH3.H20), 30% to 60% gradient in 8 min; detector, UV 254 nm. 5-(6-[[5-(4-methylpiperazin- l-yl)pyridin- 2-yl]amino]pyrimidin-4-yl)-2-(oxan-4-yloxy)benzonitrile was obtained as light yellow solid (59 mg, 44% for 2 steps). HPLC: 98.1% purity, RT = 2.51 min. MS: m/z = 472.3 [M+H]+. lH NMR (400 MHz, DMSO-/delta) delta 10.01 (s, 1 H), 8.69 (s, 1 H), 8.34-8.21 (m, 2 H), 8.04-8.01 (m, 2 H), 7.99 (s, 1 H), 7.70-7.63 (m, 1 H), 7.55-7.48 (m, 1 H), 7.48-7.40 (m, 1 H), 4.96-4.85 (m, 1 H), 3.91-3.81 (m, 2 H), 3.59-3.48 (m, 2 H), 3.15-3.08 (m, 4 H), 2.49-2.41 (m, 4 H), 2.21 (s, 3 H), 2.10- 1.95 (m, 2 H), 1.74- 1.61 (m, 2 H). Example 30: 6-([6-[3-cyano-4-(oxan-4-yloxy)phenyl]pyrimidin-4-yl]amino)-N,N- dimethylpyridine-3-carboxamide

According to the analysis of related databases, 571189-49-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; KARRA, Srinivasa R.; XIAO, YuFang; SHERER, Brian A.; CHEKLER, Eugene; (163 pag.)WO2019/79375; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 571189-49-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 571189-49-6, name is 5-(4-Methylpiperazin-1-yl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The mixture of intermediate 18 (or 24a-h or 27a-g, 0.50mmol), intermediate 19 (or 28, 0.55mmol), Pd(OAc)2 (0.05mmol), X-phos (or Xantphos, 0.15mmol), Cs2CO3 (1.25mmol) and 1,4-dioxane (or 1,2-dimethoxyethane, DME) were refluxed under argon atmosphere for 1h-4h. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography to produce title compounds 20a-d, 25a-h and 29a-g.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 571189-49-6, 5-(4-Methylpiperazin-1-yl)pyridin-2-amine.

Reference:
Article; Zhang, Hao; Wang, Jin; Zhao, Hong-Yi; Yang, Xue-Yan; Lei, Hao; Xin, Minhang; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3619 – 3633;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 571189-49-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 571189-49-6, name is 5-(4-Methylpiperazin-1-yl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-chloro-6-(2-(4-fluorophenyl)pyrrolidin-1-yl)pyrimidine compound 6 (200 mg, 0.720 mmol), 5-(4-methylpiperazin-1-yl)pyridin-2-amine compound 15 (152.30 mg, 0.792 mmol), xantphos (4,5-diphenylphosphanyl-9,9?-dimethyl-9-H-xanthene, 104.17 mg, 0.180 mmol), K2CO3 (497.63 mg, 3.60 mmol) and palladium(II) acetate (24.25 mg, 0.108 mmol) in 1,4-dioxane (10 ml) was purged with argon for 1 hour. The mixture was heated in an oil bath for overnight at 105 C. TLC was checked and the starting material was consumed. After cooling to room temperature, the reaction mixture was passed through a pad of celite using 10% MeOH/DCM and was concentrated. The crude product was purified by column chromatography (silica gel, 0-10% MeOH in DCM) to obtain compound 61 as brown solids (244 mg, 78% yield). 1H NMR (400 MHz, DMSO-d6) deltadelta 9.28 (s, 1H), 8.07 (s, 1H), 7.82 (s, 1H), 7.34 (m, 2H), 7.23 (m, 2H), 7.14 (m, 2H), 6.72 (br, 1H), 5.02 (br, 1H), 3.74 (m, 2H), 3.17 (m, 4H), 2.47-2.44 (m, 4H), 2.38 (s, 3H), 2.00-1.75 (m, 4H); ESI-MS: calcd for (C24H28FN7) 433, found 434 (MH+).

According to the analysis of related databases, 571189-49-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NantBio, Inc.; Tao, Chunlin; Wang, Qinwei; Asad, Sharif; Weingarten, Paul; Ci, Sherry; US2018/346451; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem