Category: 57266-69-0

Adding a certain compound to certain chemical reactions, such as: 57266-69-0, 3-Chloropicolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 57266-69-0, blongs to pyridine-derivatives compound. Quality Control of 3-Chloropicolinic acid

To a solution of 3-chloropyridine-2-carboxylic acid (2.1 g, 13.33 mmol, 1.00 equiv) in THF (40 mL) was added Et3N (2.7 g, 26.68 mmol, 2.00 equiv), followed by the addition of chloro(propan-2-yloxy)methanone (2.45 g, 19.99 mmol, 1.50 equiv) dropwise with stirring at 0 C. The solution was strried for 1 h at room temperture. The solid was removed by filtration. To the filtrate was added NaBH4 (1.53 g, 40.44 mmol, 3.00 equiv). The resulting solution was stirred for 2 h at rt, then diluted with 50 mL of H2O and extracted with 2*100 mL of EtOAc. The combined organic layers were washed with 50 mL of saturated Nacl, dried over Na2SO4, concentrated under vacuum, and purified with silica gel chromatography using with EtOAc/petroleum ether (1:6) to afford 0.9 g (47%) of the title compound as a colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,57266-69-0, its application will become more common.

Reference:
Patent; Vettore, LLC; PARNELL, Kenneth Mark; MCCALL, John; ROMERO, Donna; (172 pag.)US2018/162822; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 57266-69-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57266-69-0, name is 3-Chloropicolinic acid. A new synthetic method of this compound is introduced below.

To a solution of 3-chloropicolinic acid (20.006 g, 126.98 mmol) in toluene (200 mL) was added thionyl chloride (23.2 mL, 37.8 g, 317 mmol, 2.5 equiv.) and a catalytic amount of DMF (10 drops) and the mixture was heated at reflux for 1 h. After cessation of the gas evolution, the mixture was cooled and all volatiles were removed in vacuum to obtain to obtain the title compound (24.38 g, quant.) as a crude product, which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,57266-69-0, 3-Chloropicolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; DESHMUKH, Prashant; KOeRBER, Karsten; KAISER, Florian; KORDES, Markus; DICKHAUT, Joachim; NARINE, Arun; BANDUR, Nina Gertrud; VEITCH, Gemma; CULBERTSON, Deborah L.; NEESE, Paul; GUNJIMA, Koshi; WO2013/24006; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 57266-69-0 ,Some common heterocyclic compound, 57266-69-0, molecular formula is C6H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Chloro-2-picolinic acid (47.3 mg, 0.3 mmol), styrene (33 muL, 0.3 mmol), tert-butyl hypochlorite (68 muL, 0.6 mmol) was weighed into a 25 mL Schlenk reaction flask.Then THF (1 mL) was added and placed in a 25 C oil bath for 6 h. After the reaction,The solvent was removed under reduced pressure, using petroleum ether / ethyl acetate as eluent,The yield of the product was 63%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,57266-69-0, its application will become more common.

Reference:
Patent; Dalian University of Technology; Feng Xiujuan; Zhang Xitao; Bao Ming; Yu Xiaoqiang; Zhang Sheng; (24 pag.)CN110105270; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 57266-69-0, Adding some certain compound to certain chemical reactions, such as: 57266-69-0, name is 3-Chloropicolinic acid,molecular formula is C6H4ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57266-69-0.

Production example 21 (3) A mixture of 4-iodo-N1-methyl-benzene-1,2-diamine 850 mg, 3-chloro-pyridine-2-carboxylic acid 590 mg, EDC hydrochloride 790 mg, HOBt 46 mg, and pyridine 10 mL at 100C for 12 hr was stirred. To the reaction mixture was added water, and the resulting mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and then concentrated under reduced pressure. The resultant residue was treated with silica gel column chromatography to give 2-(3-chloro-pyridin-2-yl)-5-iodo-1-methyl-1H-benzimidazole (hereinafter referred to as Intermediate compound (M6-21)) 930 mg.

According to the analysis of related databases, 57266-69-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sumitomo Chemical Company, Limited; SHIMIZU, Chie; KAMEZAKI, Masashi; NOKURA, Yoshihiko; EP2952097; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem