Category: 573675-27-1

Reference of 573675-27-1 , The common heterocyclic compound, 573675-27-1, name is 3-Amino-5-bromopicolinonitrile, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 2A mixture of compound K2 (1 g, 5.05 mmol) and sodium acetate (829 mg, 10.1 mmol) in formic acid (50 mL) was stirred at reflux overnight, and then concentrated. Sodium hydroxide (3M) was added to the residue; the mixture was stirred for 10 min and filtered. The solid was washed with water and resuspended in hydrochloride (3M), stirred for another 10 min. The solid was collected and dried to give compound K3 (0.8 g). MS for K3: m/e = 226 and 228 (M+l).

The synthetic route of 573675-27-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Wen-Lian; HE, Shuwen; WALSH, Shawn, P.; CUMMING, Jared, N.; (70 pag.)WO2016/118404; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 573675-27-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.573675-27-1, name is 3-Amino-5-bromopicolinonitrile, molecular formula is C6H4BrN3, molecular weight is 198.02, as common compound, the synthetic route is as follows.

To a solution of 3-amino-5-bromopicolinonitrile (300 mg, 1.51 mmol) in 1,2-dichloroethane (5 mL) was added w-CPBA (1.23 g, 6.06 mmol) at 0 C. The reaction mixture was stirred 0 C for 1 h and then 80 C for 20 h. The reaction quenched with saturated aqueous Na2S203 (10 mL) and then extracted with DCM (10 mL x 3). The combined organics were dried over anhydrous Na2S04 and concentrated. The residue was purified by silica gel chromatography (20%-80% EtOAc /petroleum ether) to give the title compound. MS: 214, 216 (M+l).

Statistics shows that 573675-27-1 is playing an increasingly important role. we look forward to future research findings about 3-Amino-5-bromopicolinonitrile.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; ACTON, John, J., III; BAO, Jianming; DENG, Qiaolin; EGBERTSON, Melissa; FERGUSON, Ronald, III; GAO, Xiaolei; HARRISON, Scott Timothy; KNOWLES, Sandra, L.; LI, Chunsing; LO, Michael Man-Chu; MAZZOLA, Robert, D., Jr.; MENG, Zhaoyang; NA, Meng; RUDD, Michael, T.; SELYUTIN, Oleg, B.; TELLERS, David, M.; TONG, Ling; ZHANG, Fengqi; (195 pag.)WO2019/5587; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem