Category: 573762-62-6

Related Products of 573762-62-6 ,Some common heterocyclic compound, 573762-62-6, molecular formula is C7H4F3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of compound 5 (50mg, 0.26mmol) and compound 11 (66mg, 0.26mmol) in DMA (0.5ml) was added thiophosgene (32mg, 0.26mmol) under N2. The reaction mixture was stirred for 16h at 60C. To this mixture were added MeOH (2ml) and 2M HCl (2ml), then the reaction mixture was reflux for 2h. After cooling to room temperature, the reaction mixture was poured into ice water (10ml) and extracted with EtOAc (10ml). The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography on silics gel (EA/PE=1/1) to afford 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide (18) (51.3mg, 41%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Pang, Xuehai; Wang, Yingwei; Chen, Yuanwei; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2803 – 2806;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 573762-62-6, Adding some certain compound to certain chemical reactions, such as: 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile,molecular formula is C7H4F3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 573762-62-6.

Alternative syntheis of A52hr 2 hr [0090] Thiophosgene (1.23 niL, 16.0 mmol) is added dropwise to a solution of 5- amino-2-cyano-3-trifluoromethylpyridine (3.0 g, 16.0 mmol) and N-methyl-4-(l- cyanocyclobutylamino)-2-fluorobenzamide (3.96 g, 16.0 mmol) in dry DMA (35 mL) under Argon. The solution is stirred overnight at 6O0C. To this mixture were added MeOH (60 mL) and aq. 2M HCl (30 mL), then it was brought to reflux temperature for 2 h. After cooling down to the ambiant, the mixture was poured into ice water (100 mL) and extracted with EtOAc (3 x 60 mL). The organic layer was dried over Mg2SO4, filtered over celite, and concentrated under reduced pressure. Silica gel chromatography using DCM/-acetone 19-1 (v-v) yielded the desired product (5.78 g, 76%).Scale up.[0091] Thiophosgene (5.48 mL, 1.05 eq, 70.9 mmol) is added dropwise to a solution of 5-amino-2-cyano-3-trifluoromethylpyridine (13.27 g, 1.05 eq, 70.9 mmol) and N-methyl- 4-(l-cyanocyclobutylamino)-2-fluorobenzamide (16.7 g, 67.5 mmol) in dry DMA (110 mL) under Argon at 0 0C. After 10 min, the solution was heated up to 60 0C and allowed to stir at that temperature for an overnight period. This was then diluted with MeOH (200 mL) and treated with aq. 2M HCl (140 mL), then the mixture was refluxed for 2 h. After cooling down to RT, the mixture was poured into ice water (500 mL), and filtered over buchner. The solid was recrystallized from DCM/EtOH to get desired product (20.6g, 64%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; WO2008/119015; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 573762-62-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 573762-62-6 as follows.

0.8 g of 2-cyano-3-trifluoromethyl-5-aminopyridine was added to 20 ml of water.Stir vigorously,0.5 ml of thiophosgene was added dropwise over 30 minutes.After the addition, stirring was continued for 2 hours. The reaction mixture was extracted with chloroform (3×150 mL).The solid was filtered off, and the filtrate was evaporated to dryness under reduced pressure.I got ii-2 0.7 grams.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,573762-62-6, its application will become more common.

Reference:
Patent; Beijing Mei Bei Ta Pharmaceutical Co., Ltd.; Zhong Bohua; Fu Renfang; (10 pag.)CN109422725; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile, molecular formula is C7H4F3N3, molecular weight is 187.12, as common compound, the synthetic route is as follows.HPLC of Formula: C7H4F3N3

Add 99mg (0.25mmol, 1.0eq) JD1001-002-22 to a 25mL round bottom flask under nitrogen protection., 3.2 mL THF, 63 mg (0.75 mmol, 3.0 eq) NaHCO3, 140 mg (0.75 mmol, 3.0 eq)5-Amino-3-trifluoromethyl-2-cyanopyridine, stirred at 60 C for 3 hours with heating, TLC detection reaction was completed (developing agent: PE: EA = 1:1), added5 ml of water was quenched and EA was extracted to give an organic phase.Concentrating the organic phase to give a solid,Separated by HPLC (CH3CN/H2O=60:40)purification,After lyophilization, about 16 mg of product JD1001-2139 is obtained.The yield was 13%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Kunming Jida Pharmaceutical Co., Ltd.; Xiao Xuzhi; Zhang Poyong; Lu Faguan; Wang Zhipeng; Chen Mengran; Guo Kun; Zhou Rui; Zhang Yun; (28 pag.)CN109593061; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. name: 5-Amino-3-(trifluoromethyl)picolinonitrile

To a heterogeneous mixture of 2-cyano-3- (trifluoromethyl)-5-nitropyridine, A 11 (0.075 g, 0.4 mmol) in water (2 ml), thiophosgene (50 mu l) wasadded. This mixture was stirred for 2 hours, then washed with water, andextracted with chloroform. The organic layer was dried over MgSO4,concentrated to give a compound A12 (0.087g, 0.38mmol, 95%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrile.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; JUNG, MICHAEL E; SAWYERS, CHARLES L; OUK, SAMEDY; TRAN, CHRIS; WONGVIPAT, JOHN; (40 pag.)JP2016/11315; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 573762-62-6, Adding some certain compound to certain chemical reactions, such as: 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile,molecular formula is C7H4F3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 573762-62-6.

Compound 3 (0.50 g, 2.0 mmol) was added to a 25 mL two-necked flask. 3-trifluoromethyl-4 cyanoaniline (0.448 g, 2.40 mmol) and 6.5 mL N,N-dimethylacetamide, thiophosgene (0.28 ml, 3.20 mmol) was added dropwise to the solution, and the mixture was heated to 70 C for 24 h. After cooling to room temperature, 2 mL of methanol, 0.5 mL of concentrated hydrochloric acid and 2 mL of water were added, and the mixture was stirred under reflux for 2 h. After cooling to room temperature, ethyl acetate (10¡Á3 mL) was evaporated.The residue is purified by column chromatography to give compound 5, 0.286 g, pale yellow solid, yield 29.9%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 573762-62-6, 5-Amino-3-(trifluoromethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Changsha Zeda Pharmaceutical Technology Co., Ltd.; Chen Yongheng; Xu Guangyu; Zhou Wenqiang; (23 pag.)CN108976171; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 573762-62-6

SM3 (20 g) and MeCN (300 mL) were added into a four-necked round bottom flask equipped with a mechanical stirrer and a thermometer at 20-30 C. under nitrogen followed by cooling to 0-10 C. Thiophosgene (13.7 mL) was added and the mixture was warmed to 20-30 C. After the reaction was completed, the reaction mixture was cooled to 0-10 C. and added saturated NaHCO3 to adjust the pH value to 6-7. The organic layer was separated and concentrated to dryness. The compound of Formula III was obtained (24.93 g) in 100% yield as the brown oil.

With the rapid development of chemical substances, we look forward to future research findings about 573762-62-6.

Reference:
Patent; ScinoPharm Taiwan, Ltd.; Chen, Shang-Hong; Guo, Jiunn-Cheh; Shih, Wen-Li; (12 pag.)US2018/201601; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem