Category: 581-45-3

Adding a certain compound to certain chemical reactions, such as: 581-45-3, 4-(Piperidin-4-yl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 581-45-3, blongs to pyridine-derivatives compound. Recommanded Product: 4-(Piperidin-4-yl)pyridine

A mixture of 29 (0.252 g; 0.555 mmol), 4- (4-piperidinyl) pyridine (0.090 g, 0.555 mmol), [K2CO3] (0.092 g; 0.66 mmol) in acetonitrile (2 ml) was heated at [85C] under argon atmosphere for 2 hours. The crude mixture was evaporated and purified by flash chromatography eluting with a gradient 5-7% of 3.5 N [NH3] in [MEOH/METHYLENE] chloride to give after trituration in ether/pentane Example 20 as a solid. Yield: 34% [‘H NMR (CDC13)] : 1.2-1. 45 (m, 4H); 1.65 (s, 6H); 1.5-1. 8 (m, 4H); 1.8-1. 95 (m, 4H); 2.18 (t, 2H); 2.38 (s, 6H); 2.5-2. 6 (m, 1H) ; 2.7-2. 8 (m, 2H); 2.95-3. 05 (m, 2H); 3.15-3. 25 (m, 2H); 4- 4.2 (m, br, 1H) ; 4.65-4. 85 (m, br, 1H) ; 6.78 (s, 1H); 6.98 (s, 1H); 7.10 (s, 2H); 7.18 (d, 2H); 8.22 (s, 1H); 8.53 (d, 2H). MS-ESI: 581 [M+H] [+]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,581-45-3, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/18480; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 581-45-3, name is 4-(Piperidin-4-yl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 581-45-3

General procedure: The cis epoxide precursor (±)-2 was synthesized as already described [27]. In brief, elimination of water from cyclohexane-1,4-diol gave cyclohex-3-enol [40] which was epoxidized diasterioselectively by using tert-butyl hydroperoxide and Mo(CO)6 [41] to obtain the racemic epoxy alcohol. Subsequent O-p-fluorobenzylation resulted in the cis-epoxide (±)-2. To synthesize the 4-O-p-fluorobenzyl ether vesamicol derivatives (±)-3a -(±)-3m, the amine (1.41 mmol) and (±)-2 (1.12 mmol) were dissolved in 5 mL EtOH and stirred at 65-70 C for 5 days. The crude product was purified by column chromatography (silica gel 60) or by crystallization (details described for each compound). To synthesize the 5-O-p-fluorobenzyl ether vesamicol derivatives (±)-4a -(±)-4m, the cis-epoxide (±)-2 (1.12 mmol) and LiClO4 (1.97 mmol) were dissolved in 3 mL CH3CN and stirred for 10 min. Subsequently, the amine (1.41 mmol) was added and the reaction mixture was stirred at rt for 24 h. Products were purifiedby column chromatography (silica gel 60) or by crystallization (details described for each compound). The regioisomeric purity was checked by HPLC. (±)-4m (±)-5-(4-fluorobenzyloxy)-2-(4-(pyridin-4-yl)piperidin-1-yl)cyclohexanol: The crude product was purified by column chromatography using CHCl3/MeOH/NH3 (10/1/0.1). Adding of n-hexaneto a concentrated CHCl3 solution of (±)-4m and keeping afew days at 4 C resulted in the formation of 263 mg (61%) of a colorless solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 581-45-3, 4-(Piperidin-4-yl)pyridine.

Reference:
Article; Barthel, Claudia; Sorger, Dietlind; Deuther-Conrad, Winnie; Scheunemann, Matthias; Schweiger, Stephanie; Jaeckel, Petra; Roghani, Ali; Steinbach, Joerg; Schueuermann, Gerrit; Sabri, Osama; Brust, Peter; Wenzel, Barbara; European Journal of Medicinal Chemistry; vol. 100; (2015); p. 50 – 67;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 581-45-3, name is 4-(Piperidin-4-yl)pyridine. A new synthetic method of this compound is introduced below., Product Details of 581-45-3

Following the procedure of Example 74 using 5,5-Dioxo-2-(4-nitrobenzoxy-carbonylamino)dibenzothiophene (Example 24) and the appropriate amine the following compounds were prepared.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 581-45-3, 4-(Piperidin-4-yl)pyridine.

Reference:
Patent; Block, Michael Howard; Donald, Craig Samuel; Brittain, David Robert; Foote, Kevin Michael; US2003/225097; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

581-45-3, Adding a certain compound to certain chemical reactions, such as: 581-45-3, 4-(Piperidin-4-yl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 581-45-3, blongs to pyridine-derivatives compound.

4-Nitrophenyl chlorofonnate (183 mg; 0.91 mmol) was added under an argon atmosphere, at 0C, to a solution of F2 (370 mg; 0.82 mmol) and DIPEA (287 ul ; 1.65 mmol) in CH2C12 (10 ml). The mixture was stirred at 0C for 30 minutes. 4-Piperidin-4-yl pyridine (186 mg ; 1.15 mmol) was added. The mixture was stirred for 16 hours and was purified by flash chromatography with increasingly polar solutions of EtOAc/CH2C12 (0-100% EtOAc) and then MeOH/CH2Cl2 (0-15% MeOH) to give RIO as a pale yellow solid (190 mg). Yield: 36 %

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,581-45-3, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/79805; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem