Category: 581-47-5

Zhou, Xin-Yue; Zhang, Ming; Liu, Zhong; He, Jia-Hao; Wang, Xiao-Chen published the artcile< C3-Selective Trifluoromethylthiolation and Difluoromethylthiolation of Pyridines and Pyridine Drugs via Dihydropyridine Intermediates>, Electric Literature of 581-47-5, the main research area is trifluoromethylthiopyridine preparation one pot regioselective; pyridine trifluoromethylthiolation difluoromethylthiolation hydroboration oxidative aromatization; difluoromethylthiopyridine preparation regioselective one pot.

Herein, authors report a method for unprecedented C3-selective C-H tri- and difluoromethylthiolation of pyridines. The method relies on borane-catalyzed pyridine hydroboration for generation of nucleophilic dihydropyridines; these intermediates react with trifluoromethylthio and difluoromethylthio electrophiles to form functionalized dihydropyridines, which then undergo oxidative aromatization. The method can be used for late-stage functionalization of pyridine drugs for the generation of new drug candidates.

Journal of the American Chemical Society published new progress about Aromatization. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhao, Huaxin; Ma, Guobin; Xie, Xiaojuan; Wang, Yong; Hao, Jian; Wan, Wen published the artcile< Pd(II)-Catalyzed decarboxylative meta-C-H difluoromethylation>, Name: 2,4-Bipyridine, the main research area is difluoroacetic acid arylpyridine decarboxylative meta selective difluoromethylation palladium catalyst.

A palladium(II)-catalyzed decarboxylative meta-selective C-H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a migratory insertion is involved in this meta-C-H functionalization.

Chemical Communications (Cambridge, United Kingdom) published new progress about Fluoromethylation (decarboxylative). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,4-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mochizuki, Yuki; Imai, Hiroaki; Oaki, Yuya published the artcile< A Layered Polydiacetylene Containing Hydrogen-Bonding 4,4'-Bipyridyl Guests: Reversible Color Changes with a Wide-Range Temperature Response>, Application of C10H8N2, the main research area is polydiacetylene bipyridyl host guest intercalation hydrogen bonding; host-guest systems; hydrogen bonding; layered compounds; polydiacetylenes; thermoresponsive materials.

Layered organic polymers have intercalation capabilities and dynamic properties. In classical intercalation chem., the interlayer guests are intercalated in the host layers via electrostatic interaction. The present work shows the organic layered materials with the host-guest interlayer interaction via hydrogen bond. Polydiacetylene (PDA) exhibits color changes from blue to red with the application of external stimuli, such as thermal and mech. stresses. Here we report on a layered PDA containing 4,4′-bipyridyl in the interlayer space as a hydrogen-bonding guest. Whereas the layered PDA without interlayer guest shows the color transition at 65°C, gradual color changes with two-stage reversibility are observed in the temperature range of -20-240°C by the introduction of the hydrogen-bonding guest. The weaker interlayer interaction via the hydrogen bond promotes the dynamic motion directing the thermoresponsive color changes in a wide temperature range.

ChemPlusChem published new progress about Color. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jin-Biao; Wu, Chun; Chen, Feng; Leung, Chung-Hang; Ma, Dik-Lung published the artcile< A simple iridium(III) dimer as a switch-on luminescent chemosensor for carbon disulfide detection in water samples>, Application of C10H8N2, the main research area is iridium dimer luminescent chemosensor carbon disulfide water; Carbon disulfide; Chemosensor; Iridium(III) dimer; Luminescence.

A series of iridium(III) dimers were synthesized and their ability to interact with diethyldithiocarbamate for CS2 sensing was evaluated. Upon the addition of CS2, diethylamine can capture CS2 to form diethyldithiocarbamate, which could chelate with the iridium(III) dimer to form a diethyldithiocarbamate iridium(III) complex, resulting in a yellow luminescence. Dimer 8 exhibited a maximum 18-fold of luminescence enhancement upon the addition of CS2. The luminescence signal of the detection system could be readily distinguished from the highly fluorescent media using time-resolved emission spectroscopy (TRES). The capability of the system to determine CS2 level in water samples was also demonstrated.

Analytica Chimica Acta published new progress about Environmental analysis. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yao, Kun; Yuan, Qianjia; Qu, Xingxin; Liu, Yangang; Liu, Delong; Zhang, Wanbin published the artcile< Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed in situ as nucleophiles>, Related Products of 581-47-5, the main research area is chiral piperidinyl amino acid enantioselective preparation.

Chiral piperidine-containing amino acid derivatives, e.g., I, were synthesized via Pd-catalyzed asym. allylic substitution cascade reaction of cinnamyl carbonates, chloroacetamides and substituted pyridines. In situ generated α-(pyridin-1-yl)-acetamides were used as nucleophiles in this cascade reaction. The products could be easily converted into potential bioactive compounds, unnatural chiral amino acids and dipeptides. Pd-catalyzed asym. allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed in situ as nucleophiles.

Chemical Science published new progress about Amides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pang, Jia Hao; Kaga, Atsushi; Roediger, Sven; Lin, Min Htoo; Chiba, Shunsuke published the artcile< Revisiting the Chichibabin Reaction: C2 Amination of Pyridines with a NaH-Iodide Composite>, COA of Formula: C10H8N2, the main research area is pyridine preparation Chichibabin.

A NaH-iodide composite was found capable of mediating the Chichibabin amination under mild reaction conditions, allowing efficient access to a range of 2-aminopyridines and their derivatives

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chai, Jingchao; Lashgari, Amir; Wang, Xiao; Jiang, Jianbing Jimmy published the artcile< Extending the redox potentials of metal-free anolytes: towards high energy density redox flow batteries>, SDS of cas: 581-47-5, the main research area is phenylpyridine energy density redox flow battery metal free anolyte.

Non-aqueous organic redox flow batteries (NORFBs) have emerged as a promising technol. for renewable energy storage and conversion. High capacity and power d. can be achieved by virtue of high solubility and high operating voltage of the organic anolytes and catholytes in organic media. However, the lack of anolyte materials with high redox potentials and their poor electrochem. stability retard the wider application of NORFBs. Here, we investigated an evolutionary design of a set of bipyridines and their analogs as anolytes and examined their performance in full fl ow batteries. Using combined techniques of repeated voltammetry, lower scan rate cyclic voltammetry, proton NMR, and d. functional theory calculations, we could rapidly evaluate the redox potential, stability, and reversibility of these redox candidates. The promising candidates, 4-pyridylpyridinium bis(trifl uoromethanesulfonyl)imide (monoMebiPy) and 4,4′-bipyridine (4,4′-biPy), were subjected to battery cycling. Extended studies of the post-cycling electrolytes were conducted to analyze the pathway of capacity fading and revealed a reduction-promoted Me group shift mechanism for monoMebiPy. A family of easily accessible anolyte mols. with high redox stability and redox potentials was discovered that can be applied in NORFBs.

Journal of the Electrochemical Society published new progress about Battery electrolytes. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alijevic, Omar; McHugh, Damian; Rufener, Lucien; Mazurov, Anatoly; Hoeng, Julia; Peitsch, Manuel published the artcile< An electrophysiological characterization of naturally occurring tobacco alkaloids and their action on human α4β2 and α7 nicotinic acetylcholine receptors>, Category: pyridine-derivatives, the main research area is Nicotiana solanaceae tobacco alkaloids nAChR nicotine anabasine anatabine; Anabasine; Anatabine; Nicotiana tabacum; Nicotine; Nornicotine; Solanaceae; Tobacco alkaloids; nAChR; α4β2; α7.

Nicotinic acetylcholine receptor (nAChR) subtype-selective pharmacol. profiles of tobacco alkaloids are essential for understanding the physiol. effects of tobacco products. In this study, automated electrophysiol. was used to functionally characterize the effects of distinct groups of tobacco alkaloids on human α4β2 and α7 nAChRs. We found that, in tobacco alkaloids, pyridine as a hydrogen bond acceptor and a basic nitrogen atom at a distance of 4-7 Å are pharmacophoric elements necessary for mol. recognition by α4β2 and α7 nAChRs with various degrees of selectivity, potency, and efficacy. While four alkaloids-nicotine, nornicotine, anabasine and R-anatabine-potently activated α4β2, they were also weak agonists of α7 nAChRs. Nicotine was the most potent agonist of α4β2, while anabasine elicited the highest activation of α7. None of the tobacco alkaloids enhanced nAChR activity elicited by the endogenous ligand acetylcholine; therefore, none was considered to be a pos. allosteric modulator (PAM) of either α4β2 or α7 nAChRs. In contrast, we identified tobacco alkaloids, such as the tryptophan metabolite 6-hydroxykynurenic acid, that decreased the activity of both α4β2 and α7 nAChRs. Our study identified a class of alkaloids with pos. and neg. effects against human α4β2 and α7 nAChRs. It also revealed human α4β2 to be the principal receptor for sensing the most abundant alkaloids in tobacco leaves.

Phytochemistry (Elsevier) published new progress about Alkaloids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (tobacco alkaloids). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Beddoe, Samuel V. F.; Lonergan, Rhona F.; Pitak, Mateusz B.; Price, Jason R.; Coles, Simon J.; Kitchen, Jonathan A.; Keene, Tony D. published the artcile< All about that base: investigating the role of ligand basicity in pyridyl complexes derived from a copper-Schiff base coordination polymer>, Recommanded Product: 2,4-Bipyridine, the main research area is copper hydroxybenzylideneaminophenol pyridine benzimidazole complex preparation; crystal structure copper hydroxybenzylideneaminophenol pyridine benzimidazole complex.

The role of ligand basicity in complex formation was studied using monodentate pyridyls or benzimidazole (mP) in combination with a solution-stable species derived form a coordination polymer, [Cu(L)] (L = 2-(2-hydroxybenzylidene-amino)phenol). The 12 [Cu(L)(mP)n] generated, combined with the {[Cu(L)]2(pP)} complexes from the authors’ previous work (pP is a polypyridyl ligand), allow the authors to gauge the likelihood of complex formation based on the pKa of the conjugate acid of the pyridyl ligands and Hammett parameter, σ. Above pKa ≈ 4.5, complexes are formed where the only ligands are L2- and mP or pP and the packing interactions are predominantly van der Waals. Below this value, complex formation is unlikely unless there are addnl. oxygen ligands in the Jahn-Teller axis of the Cu(II) ion. The structures of two literature [Cu(L)(bP)], where bP is a chelating bidentate pyridyl ligand are also reexamined to resolve the positional disorder in the [Cu(L)] moiety.

Dalton Transactions published new progress about Crystal structure. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,4-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Horan, Alexandra M.; Duong, Vincent K.; McGarrigle, Eoghan M. published the artcile< Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts>, Related Products of 581-47-5, the main research area is bis heteroaryl preparation; halopyridine pyridylsulfonium salt coupling reaction.

Herein ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts I (R = H, Br, Me, trifluoromethyl; R1 = H, OMe, CN, Br, etc.; R2 = H, trifluoromethyl; R3 = H, Me; R2R3 = -(CH=CH-CH=CH)-) and phenyl(pyrimidin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate are reported. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages including 2,4′-bipyridines, 2,3′-bipyridines, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes II (R4 = 2-fluoropyridin-4-yl, pyrazin-2-yl, dimethyl-1,2-oxazol-4-yl, 1-benzothiophen-2-yl, etc.). The methodol. was successfully applied to the synthesis of the natural products caerulomycin A and E.

Organic Letters published new progress about Coupling reaction. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem