582303-10-4 | Page 2 of 2 | Pyridine-derivatives

Introduction of a new synthetic route about (2,6-Dimethylpyridin-3-yl)methanol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol.

Synthetic Route of 582303-10-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of methyl ( 6-hydroxy-4-vinyl-l- benzothiophen-3-yl) acetate (351 mg) and THF (dry) (3 mL) were added (2, 6-dimethylpyridin-3-yl) methanol (233 mg) , ADDP (535 mg) and tri-n-butylphosphine (0.523 mL) at room temperature. The precipitate was removed by filtration, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane ) to give the title compound (459 mg) . XH NMR (300 MHz, CDC13) delta 2.54 (3H, s) , 2.58 (3H, s) , 3.68-3.72 (3H, m) , 3.98 (2H, s) , 5.07 (2H, s) , 5.35-5.43 (1H, m) , 5.51- 5.61 (1H, m) , 6.99-7.06 (2H,m) , 7.12 (1H, s) , 7.28-7.41 (2H, m) , 7.61 (1H, d, J = 7.9 Hz) .

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei; WO2013/125732; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of (2,6-Dimethylpyridin-3-yl)methanol

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

To a mixture of tri-n-butylphosphine (0.240 mL) , (2,6- dimethylpyridin-3-yl) methanol (92 mg) , methyl ( 6-hydroxy-4 , 7- dimethyl-l-benzofuran-3-yl) acetate (150 mg) and THF (6.0 mL) was added ADDP (242 mg) at room temperature. The mixture was stirred at room temperature overnight under nitrogen atmosphere. The mixture was concentrated. To the residue was added IPE and the precipitate was filtered off and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (163.9 mg) . XK NMR (300 MHz, CDC13) delta 2.33 (3H, s) , 2.54 (3H, s) , 2.55 (3H, s), 2.58 (3H, s), 3.73 (3H, s) , 3.80 (2H, d, J = 1.1 Hz), 5.04 (2H, s), 6.68 (1H, s) , 7.02 (1H, d, J = 7.6 Hz), 7.51 (1H, s) , 1.63 (1H, d, J = 7.9 Hz)

Extracurricular laboratory: Synthetic route of 582303-10-4

Statistics shows that 582303-10-4 is playing an increasingly important role. we look forward to future research findings about (2,6-Dimethylpyridin-3-yl)methanol.

Related Products of 582303-10-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.

A mixture of lambda/-[(2S)-5-hydroxy-2,3-dihydro-1 H-inden-2-yl]-2-propanesulfonamide (149 mg, 0.583 mmol, Description 3) and (2,6-dimethyl-3-pyridinyl)methanol (80 mg, 0.583 mmol) in dichloromethane (10 ml) was stirred under argon at room temperature. Triphenylphosphine (153 mg, 0.583 mmol) and DIAD (0.113 ml, 0.583 mmol) were then successively added. The resulting mixture was stirred at room temperature under argon for 16 hours. Then the reaction mixture was washed with water, dried over sodium sulphate, filtered and evaporated. The desired product was isolated by MDAP, concentrated to a small volume, and partitioned between dichloromethane and aqueous sodium hydrogen carbonate solution. The organic phase was dried over sodium sulphate, filtered and evaporated in vacuo to afford the desired compound as a free base. This was treated with ethereal hydrochloride / methanol to give the title compound as a white solid (92 mg).LC/MS (ES): Found 375 (ES+), retention time 1.67mins. C20H26N2O3S requires 374. 1 H-NMR (400MHz, DMSOd6): delta 8.34 (1 H, bs), 7.69 (1 H, bs), 7.46 (1 H, d, J=8.0Hz), 7.14 (1 H, d, J=8.0Hz), 6.94 (1 H, s), 6.84 (1 H, m), 5.19 (2H, s), 4.06 (1 H, m), 3.24-3.06 (3H, m), 2.87-2.74 (2H, m), 2.69 (3H, s), 2.60 (3H, s), 1.25 (6H, d, J=6.8Hz).

Statistics shows that 582303-10-4 is playing an increasingly important role. we look forward to future research findings about (2,6-Dimethylpyridin-3-yl)methanol.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/80637; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of (2,6-Dimethylpyridin-3-yl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol, and friends who are interested can also refer to it.

Related Products of 582303-10-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol. A new synthetic method of this compound is introduced below.

To a mixture of methyl ( 4-chloro-6-hydroxy-l- benzothiophen-3-yl) acetate (110 mg) and THF (dry) (5 mL) were added (2 , 6-dimethylpyridin-3-yl) methanol (58.8 mg) , tri-n- butylphosphine (0.159 mL) and ADDP (130 mg) at room temperature. The mixture was stirred at room temperature for 12 h. The insoluble material was removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (139 mg) . XH NMR (300 MHz, CDC13) delta 2.54 (3H, s) , 2.57 (3H, s) , 3.73 (3H, s), 4.11 (2H, s), 5.05 (2H, s) , 7.02 (1H, d, J = 7.9 Hz), 7.06- 7.09 (1H, m) , 7.13 (1H, s) , 7.29 (1H, s) , 7.58 (1H, d, J = 7.9 Hz) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol, and friends who are interested can also refer to it.