Category: 5832-43-9

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5832-43-9, name is 4-Methyl-5-nitropicolinic acid, molecular formula is C7H6N2O4, molecular weight is 182.13, as common compound, the synthetic route is as follows.Formula: C7H6N2O4

To a solution of 4-methyl-5-nitro-2-pyridinecarboxylic acid (1.0 g, 5.5 mmol) in methanol (50 mL) was added concentrated HQ (8 mL, 97 mmol) at room temperature. The mixture was heated at reflux for 18h, then cooled to room temperature. The crude mixture was partitioned between EtOAc and saturated NaHCO3 and the aqueous layer was extracted with EtOAc (twice). The combined organic phase was washed with brine, dried over anhydrous MgS0 , filtered and concentrated to provide methyl 4-methyl-5-nitropicolinate. -NMR (CDC13, 500 MHz), delta 9.23 (s, 1H), 8.16 (s, 1H), 4.06 (s, 3H), 2.77 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5832-43-9, 4-Methyl-5-nitropicolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn, P.; CATO, Brian; FRIE, Jessica, L.; KIM, Dooseop; PASTERNAK, Alexander; SHI, Zhi-Cai; WO2014/85210; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5832-43-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5832-43-9, name is 4-Methyl-5-nitropicolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Methyl 4-methyl -5-nitropicol i nateTo a solution of 4-methyl-5-nitropicolinic acid (5.0 g, 27.5 mmol) in methanol (60 mL) was slowly added concentrated sulfuric acid (4.39 mL, 82 mmol) and the mixture was refluxed under argon for 18 h. The volatiles were evaporated and a sat. aq. solution of NaHCO3 was added slowly until the aqueous phase showed a pH of 7-8. The resultant mixture was extracted with CH2CI2 (x3), the combined organic extracts were dried (phase separator) and concentrated under vacuum. MS (UPLC-MS): 197.0 [M+H]+, tR (HPLC conditions h): 1.99 mm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5832-43-9, 4-Methyl-5-nitropicolinic acid.

Reference:
Patent; NOVARTIS AG; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; RANDL, Stefan Andreas; VULPETTI, Anna; WO2014/2057; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem