Adding a certain compound to certain chemical reactions, such as: 58481-04-2, 2-Chloroisonicotinohydrazide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloroisonicotinohydrazide, blongs to pyridine-derivatives compound. Safety of 2-Chloroisonicotinohydrazide
EXAMPLE 3; This Example illustrates the preparation of compound ni. 3,2-chloroisonicotinic acid [1′- [trans-3- (4-chlorophenyl) allyl] spiro [indan-1-ylidene-3, 4′-piperidine]] hydrazide; To a solution of l’- [trayzs-3- (4-chlorophenyl) allyl] spiro [indan-1-one-3, 4′-piperidine] (example 1, step B) (20 mg) in ethanol (3 ml) was added 2-chloro-isonicotinic acid hydrazide (15 mg) and one drop of sulphuric acid. The reaction mixture was refluxed for 12 hours and concentrated in vacuo. The residue was dissolved in dichloromethane, washed with saturated aqueous sodium bicarbonate, dried (sodium sulphate) and concentrated in vacuo. The solid residue was purified by preparative HPLC to give 22 mg of 2- chloroisonicotinic acid [1′- [trans-3- (4-chlorophenyl) allyl] spiro [indan-1-ylidene-3, 4′- piperidine] ] hydrazide; M. p. 240C. IH NMR (400 MHz, CDCl3) 1.5 (m, 2H), 2.15 (m, 4H), 2.70 (s, 2H), 3.03 (m, 2H), 3.21 (m, 2H), 6.26 (dt, J = 15.8 Hz, 5.8 Hz, 1H), 6.45 (d, J = 15.8Hz, 1H), 7.1-7. 9 (m, 10H) ; 8.50 (d, J = 4.7 Hz, 1H), 9.42 (br s, 1H) ; MS (ES+) 505/507 (M+H+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,58481-04-2, 2-Chloroisonicotinohydrazide, and friends who are interested can also refer to it.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2005/58836; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem