Category: 58483-95-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58483-95-7, name is 5-Amino-2-chloropyridine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

General procedure: A mixture of compound 5-amino-2-chloropyridine-4-carboxylic acid(1000 g, 5.8 mol) was dissolved in 5000 mlEthylene glycol monomethyl ether, AddedFormamidine hydrochloride(1867 g, 23.2 mol), sodium acetate (2360 g, 17.4 mol). The reaction was heated to 120 ° C for 6 hours. After the reaction was complete, the reaction was cooled to room temperature, poured into 4000 ml of water and extracted twice with ethyl acetate. The organic phase was combined, dried and concentrated to afford the crude product which was filtered to give 6-chloropyridine And [3,4-d] pyrimidin-4 (3H) ketone (924 g, 5-1 mol)

With the rapid development of chemical substances, we look forward to future research findings about 58483-95-7.

Reference:
Patent; Bide Pharmatech Ltd.; Li, Jinfei; Li, Xinling; Huang, Liangfu; Ou, Yanghao; (7 pag.)CN104130256; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 58483-95-7 , The common heterocyclic compound, 58483-95-7, name is 5-Amino-2-chloropyridine-4-carboxylic acid, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-Chloro-3H-pyrido[3,4-d]pyrimidin-4-one. A solution of 5-amino-2-chloropyridine-4-carboxylic acid (8.1 g, 4.7 mmol) in formamide (100 mL) is stirred at 140° C. for 12 h. Dilution of the cooled mixture with water gives a precipitate of 6-chloro-3H-pyrido[3,4-d]pyrimidin-4-one (7.3 g, 86percent yield). 1 H NMR (DMSO) delta 12.73 (1H, m), 8.90 (1H, d, J=0.7 Hz), 8.23 (1H, s), 7.97 (1H, d, J=0.7 Hz).

The synthetic route of 58483-95-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Warner-Lambert Company; US5654307; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 58483-95-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58483-95-7, name is 5-Amino-2-chloropyridine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

5-amino-2-chloro isonicotinic acid (30g, 0.1738mol, 1.0eq), was dissolved in N,N-dimethylformamide (300 mL) in added portionwise at 0°C, N,N’-carbonyldiimidazole imidazole (48g, 0.2955mol, 1.7eq), was slowly warmed to room temperature overnight.LC-MS showed the reaction was complete, cooled to room temperature, the next step without treatment.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58483-95-7, 5-Amino-2-chloropyridine-4-carboxylic acid.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Yang Xiaoju; (118 pag.)CN109575016; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 58483-95-7, 5-Amino-2-chloropyridine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H5ClN2O2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H5ClN2O2

The mixture of 5-amino-2-chloroisonicotinic acid (5.00g, 29.07mmol) and formamidine acetate (6.00g, 58.14mmol) was stirred at 160°C for 0.5h, cooled, water (100mL) was added. The mixture was refluxed under vigorous stirring for 20min, cooled again. The precipitate formed was collected, washed with water and dried to give 4.74g intermediate 15 as off-white power. Yield 90.4percent. mp>320°C. MS m/z (ESI) 182.4 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-95-7, 5-Amino-2-chloropyridine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Hao; Wang, Jin; Zhao, Hong-Yi; Yang, Xue-Yan; Lei, Hao; Xin, Minhang; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3619 – 3633;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem