Category: 58483-98-0

Related Products of 58483-98-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, molecular weight is 216.04, as common compound, the synthetic route is as follows.

A mixture of 2-amino-5-bromonicotinamide (100 mg, 0.46 mmol), 3-fluorobenzaldehyde (69 mg, 0.56 mmol), NaHSO3 (40 mg, 0.38 mmol), 4-methylbenzene sulfonicacid (15 mg, 0.05 mmol) in DMAc (3 mL) was stirred at 115C for 1.5 h, then additional NaHSO3(40 mg, 0.38 mmol) was added to the mixture. After 1.5 h, the third portion of NaHSO3 (40 mg,0.38 mmol) was added to the mixture. After being stirred overnight at 115C, the reaction mixturewas concentrated in vacuo, suspended in water and filtered to give the product of 6-bromo-2-(3-fluorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one (70 mg, yield: 47%), which was used for the nextstep without further purification. ?H-NMR (DMSO-d6, 400 MHz) 13.04 (br s, 1H), 9.07 (d, J2.8 Hz, 1H), 8.65 (d, J= 2.8 Hz, 1H), 8.08 (d, J= 8.0 Hz, 1H), 8.02 (dd, J= 9.6, 1.6 Hz, 1H), 7.607.68 (m, 1H), 7.457.54 (m, 1H). MS (M+H): 320/322.

Statistics shows that 58483-98-0 is playing an increasingly important role. we look forward to future research findings about 2-Amino-5-bromonicotinamide.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 58483-98-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, molecular weight is 216.04, as common compound, the synthetic route is as follows.

To a mixture of 2-amino-5-bromonicotinamide (200 mg, 0.93 mmol), thiophene-2- carbaldehyde (125 mg, 1.11 mmol) in MeOH (15 mL) was added 4-methylbenzenesulfonic acid (16mg, 0.09 mmol). The mixture was stirred at 60C overnight. Then the resulting solid was filtered to give the product of 6-bromo-2-(thiophen-2-yl)-2,3 -dihydropyrido [2 ,3-d]pyrimidin-4( 1 H)-one (180 mg, yield: 63%), which was used for the next step without further purification. ?H NMR (DMSO-d6, 400 MHz) 8.93 (d, J= 2.4 Hz, 1H), 8.42 (s, 1H), 8.28 (d, J= 2.4 Hz, 1H), 7.98 (d, J= 2.4 Hz, 1H),7.45 (dd, J= 4.8 Hz, 1.2 Hz, 1H), 7.08 (d, J= 3.2 Hz, 1H), 6.98 (dd, J= 4.8 Hz, 3.2 Hz, 1H), 6.10 (t,J= 2.4 Hz, 1H). MS (M+H): 310 / 312.

The chemical industry reduces the impact on the environment during synthesis 58483-98-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/205593; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 58483-98-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 58483-98-0, name is 2-Amino-5-bromonicotinamide. A new synthetic method of this compound is introduced below.

Oxalyl chloride (100 mL, 1.16 mmol) was added dropwise to a suspension of 2- amino-5-bromo-nicotinamide (500 mg, 2.31 mmol) in toluene (5 mL) and the resulting mixture was heated to reflux for 4 h. The reaction mixture was cooled and the mustard- colored solid which had formed was collected by filtration. The solid was washed with a small amount of water, MEOH, and then dried under high vacuum (40 C) overnight to give the title compound (435 mg, 77%) :’H NMR (300 MHz, DMSO-D6) 8 11.86 (s, 1H), 11.60 (s, 1H), 8.72 (d, J = 2.5 Hz, 1H), 8. 35 (d, J = 2.5 Hz, 1 H) ; 13C NMR (126 MHz, DMSO-d6) 8 161.4, 154.8, 151.2, 150.17, 137.8, 112.6, 111.6.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-98-0, 2-Amino-5-bromonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2004/52890; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 58483-98-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 58483-98-0, name is 2-Amino-5-bromonicotinamide. A new synthetic method of this compound is introduced below.

Oxalyl chloride (100 mL, 1.16 mmol) was added dropwise to a suspension of 2- amino-5-bromo-nicotinamide (500 mg, 2.31 mmol) in toluene (5 mL) and the resulting mixture was heated to reflux for 4 h. The reaction mixture was cooled and the mustard- colored solid which had formed was collected by filtration. The solid was washed with a small amount of water, MEOH, and then dried under high vacuum (40 C) overnight to give the title compound (435 mg, 77%) :’H NMR (300 MHz, DMSO-D6) 8 11.86 (s, 1H), 11.60 (s, 1H), 8.72 (d, J = 2.5 Hz, 1H), 8. 35 (d, J = 2.5 Hz, 1 H) ; 13C NMR (126 MHz, DMSO-d6) 8 161.4, 154.8, 151.2, 150.17, 137.8, 112.6, 111.6.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-98-0, 2-Amino-5-bromonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2004/52890; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, molecular weight is 216.04, as common compound, the synthetic route is as follows.Computed Properties of C6H6BrN3O

To a mixture of 2-amino-5-bromonicotinamide (200 mg, 0.93 mmol), thiophene- 2-carbaldehyde (125 mg, 1.11 mmol) in MeOH (15 mL) was added 4-methylbenzenesulfonic acid (16 mg, 0.09 mmol). The mixture was stirred at 60C overnight. Then the resulting solid was filtered to give the product of 6-bromo-2-(thiophen-2-yl)-2,3-dihydropyrido[2,3- d]pyrimidin-4(lH)-one (180 mg, yield: 63%), which was used for the next step without further purification. NMR (DMSO-ifc, 400 MHz) delta 8.93 (d, J= 2.4 Hz, 1H), 8.42 (s, 1H), 8.28 (d, J = 2.4 Hz, 1H), 7.98 (d, J= 2.4 Hz, 1H), 7.45 (dd, J= 4.8 Hz, 1.2 Hz, 1H), 7.08 (d, J= 3.2 Hz, 1H), 6.98 (dd, J= 4.8 Hz, 3.2 Hz, 1H), 6.10 (t, J= 2.4 Hz, 1H). MS (M+H)+: 310 / 312.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-98-0, 2-Amino-5-bromonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, molecular weight is 216.04, as common compound, the synthetic route is as follows.Computed Properties of C6H6BrN3O

To a mixture of 2-amino-5-bromonicotinamide (200 mg, 0.93 mmol), thiophene- 2-carbaldehyde (125 mg, 1.11 mmol) in MeOH (15 mL) was added 4-methylbenzenesulfonic acid (16 mg, 0.09 mmol). The mixture was stirred at 60C overnight. Then the resulting solid was filtered to give the product of 6-bromo-2-(thiophen-2-yl)-2,3-dihydropyrido[2,3- d]pyrimidin-4(lH)-one (180 mg, yield: 63%), which was used for the next step without further purification. NMR (DMSO-ifc, 400 MHz) delta 8.93 (d, J= 2.4 Hz, 1H), 8.42 (s, 1H), 8.28 (d, J = 2.4 Hz, 1H), 7.98 (d, J= 2.4 Hz, 1H), 7.45 (dd, J= 4.8 Hz, 1.2 Hz, 1H), 7.08 (d, J= 3.2 Hz, 1H), 6.98 (dd, J= 4.8 Hz, 3.2 Hz, 1H), 6.10 (t, J= 2.4 Hz, 1H). MS (M+H)+: 310 / 312.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-98-0, 2-Amino-5-bromonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, molecular weight is 216.04, as common compound, the synthetic route is as follows.Computed Properties of C6H6BrN3O

To a mixture of 2-amino-5-bromonicotinamide (200 mg, 0.93 mmol), thiophene- 2-carbaldehyde (125 mg, 1.11 mmol) in MeOH (15 mL) was added 4-methylbenzenesulfonic acid (16 mg, 0.09 mmol). The mixture was stirred at 60C overnight. Then the resulting solid was filtered to give the product of 6-bromo-2-(thiophen-2-yl)-2,3-dihydropyrido[2,3- d]pyrimidin-4(lH)-one (180 mg, yield: 63%), which was used for the next step without further purification. NMR (DMSO-ifc, 400 MHz) delta 8.93 (d, J= 2.4 Hz, 1H), 8.42 (s, 1H), 8.28 (d, J = 2.4 Hz, 1H), 7.98 (d, J= 2.4 Hz, 1H), 7.45 (dd, J= 4.8 Hz, 1.2 Hz, 1H), 7.08 (d, J= 3.2 Hz, 1H), 6.98 (dd, J= 4.8 Hz, 3.2 Hz, 1H), 6.10 (t, J= 2.4 Hz, 1H). MS (M+H)+: 310 / 312.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-98-0, 2-Amino-5-bromonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 58483-98-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-amino-5-bromonicotinamide (100 mg, 0.46 mmol), 3- fluorobenzaldehyde (69 mg, 0.56 mmol), NaHSC>3 (40 mg, 0.38 mmol), 4-methylbenzene sulfonic acid (15 mg, 0.05 mmol) in DMAc (3 mL) was stirred at 115C for 1.5 h, then additional NaHSC>3 (40 mg, 0.38 mmol) was added to the mixture. After 1.5 h, the third portion of NaHSC>3 (40 mg, 0.38 mmol) was added to the mixture. After being stirred overnight at 115C, the reaction mixture was concentrated in vacuo, suspended in water and filtered to give the product of 6-bromo-2-(3-fluorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one (70 mg, yield: 47%), which was used for the next step without further purification. XH-NMR (DMSO-i, 400 MHz) delta 13.04 (br s, 1H), 9.07 (d, J= 2.8 Hz, 1H), 8.65 (d, J= 2.8 Hz, 1H), 8.08 (d, J= 8.0 Hz, 1H), 8.02 (dd, J= 9.6, 1.6 Hz, 1H), 7.60-7.68 (m, 1H), 7.45-7.54 (m, 1H). MS (M+H)+: 320/322.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58483-98-0, 2-Amino-5-bromonicotinamide.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem