Category: 585-48-8

Application of 585-48-8 ,Some common heterocyclic compound, 585-48-8, molecular formula is C13H21N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 197 (R)-N-(2-Chloro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide Oxalyl chloride (1.07 ml) was added dropwise to a stirred suspension of (R)-(+)-2-hydroxy-2-methyl-3,3,3-trifluoropropanoic acid (Method 9) (1.95 g) in DCM (42 ml) and DMF (0.8 ml). The mixture was stirred at ambient temperature for 2 hours and was then added over 35 minutes to a solution of 2-chloro-4-iodoaniline (2.5 g) and 2,6-di-t-butylpyridine (2.94 ml) in DCM (40 ml) and stirred a further 18 hours. Volatile material was removed by evaporation and the residue was purified by flash chromatography on silica gel eluding with DCM to give the title compound (2.85 g) as a solid. NMR: 1.6 (s, 3H), 7.7 (m, 2H), 7.8 (d, 1H), 7.9 (brs, 1H); MS (ESP-): 392.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 585-48-8, 2,6-Di-tert-butylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AstraZeneca AB; US6498275; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 585-48-8, name is 2,6-Di-tert-butylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 585-48-8

Example 26 5-(S)-Acetamidomethyl-3-[4′-formamido-3′-fluorophenyl]oxazolidine-2-one A solution of 5-(S)-acetamidomethyl-3-[4′-amino-3′-fluorophenyl]-oxazolidine-2-one (0.200 g, 0.748 mmol), p-nitrophenyl formate (0.188 g, 1.12 mmol), and 2,6-di-(tert-butyl)pyridine (0.336 mL, 1.50 mmol) in THF (4 mL) was stirred at 65 C. overnight. Solvent was removed under vacuum and the residue purified by PTLC (30% acetone in DCM) to give product as a white solid (0.188 g, 85%). M.p. 196-8 C.; MS (m/z): [M+H]+=296.

With the rapid development of chemical substances, we look forward to future research findings about 585-48-8.

Reference:
Patent; Pharmacia & Upjohn Company; US6441005; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 585-48-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 585-48-8, name is 2,6-Di-tert-butylpyridine. A new synthetic method of this compound is introduced below.

c Trifluoromethanesulfonic acid 2-amino-5-fluoro-6-furan-2-yl-pyrimidin-4-yl ester To a stirred suspension of 0.5 g (2.58 mmol) 2-amino-5-fluoro-6-furan-2-yl-3H-pyrimidin-4-one in 5 ml dichloromethane was added 1.16 ml (5.17 mmol) 2,6-di-tert-butylpyridine and the mixture was ultrasonicated for 30 minutes. 0.42 ml (2.55 mmol) triflic anhydride was then added dropwise at 0 C. with stirring and stirring continued at room temperature for 16 hours. The reaction mixture was then partitioned between water and dichloromethane and the organic phase was dried over sodium sulfate and concentrated in vacuo. The residue was recrystallized from ether/hexane and the resulting crystals (2,6-di-tert-butylpyridinium triflate) were removed by filtration. The mother liquor was concentrated in vacuo to afford 0.84 g (99%) trifluoromethanesulfonic acid 2-amino-5-fluoro-6-furan-2-yl-pyrimidin-4-yl ester as a brown crystalline solid. ES-MS m/e (%): 326 ([M-H]-, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,585-48-8, its application will become more common.

Reference:
Patent; Borroni, Edilio Maurizio; Huber-Trottmann, Gerda; Kilpatrick, Gavin John; Norcross, Roger David; US2001/27196; (2001); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

585-48-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 585-48-8, name is 2,6-Di-tert-butylpyridine, molecular formula is C13H21N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 16 1-(1-Naphthoyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S,R)-(ethoxymethyl)pyrrolidine To a solution of 0.033 g (0.074 mmol) of 1-(1-naphthoyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-hydroxymethylpyrrolidine and 0.057 g (0.22 mmol) of AgOTf in 2 mL of CH2Cl2 was added 0.058 mL (0.26 mmol) of 2,6-di-t-butylpyridine and 0.019 mL (0.24 mmol) of ethyl iodide and the reaction mixture was stirred at rt for 1.5 h. The reaction mixture was diluted with CH2Cl2 and filtered through a thin pad of Celite eluding with acetone:hexanes (1:2). The filtrate was concentrated and the residue was purified by chromatography (silica, acetone:hexanes, 1:3 to 1:2) to give the title compound. 1H NMR (CDCl3) delta (key peaks) 7.88-7.91 (M, 3H), 7.47-7.57 (M, 4H), 7.09-7.12 and 7.18-7.21 (M, 2H, 7.01 and 6.96 (t, 2H, J=8.5 Hz), 1.25 and 1.09 (t, 3H, J=7.0 Hz); Mass Spectrum (ESI) m/e=475 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 585-48-8, 2,6-Di-tert-butylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck & Co., Inc.; US6372764; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem