Category: 58539-77-8

Synthetic Route of 58539-77-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 58539-77-8, name is 3-(Chloromethyl)-2-methylpyridine hydrochloride. A new synthetic method of this compound is introduced below.

A mixture of the compound of Example 42 (0.20 g, 0.57 [MMOL),] cesium carbonate (2.0 g, 5.7 [MMOL)] and 3-chloromethyl-2-methyl-pyridine hydrochloride (0.16 g, 0.91 [MMOL)] in a 2: 1 THF/DMF mixture was heated at [80C] for 15 hours. The cooled mixture was filtered and concentrated, and then water (30 mL) was added and the mixture extracted with ethyl acetate (3 x 30 mL). The combined organic layers were washed with brine, dried [(MGS04),] filtered and concentrated to a foam (0.31 [G).] The residue was purified by flash chromatography using a 30% to 70% ethyl acetate/hexanes eluant to afford 122 mg (47%) of the title compound as an oil. Mass spectrum: (m/e) 458 (M++1, +ion).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,58539-77-8, its application will become more common.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/5229; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58539-77-8, name is 3-(Chloromethyl)-2-methylpyridine hydrochloride, molecular formula is C7H9Cl2N, molecular weight is 178.06, as common compound, the synthetic route is as follows.Product Details of 58539-77-8

To the mixture of methyl 2-(4-aminopiperidin-1-yl)acetate hydrochloride (190 mg, 0.78 mmol) and 3-(chloromethyl)-2-methylpyridine hydrochloride (151 mg, 0.85 mmol) in DMF (3 mL) was added K2CO3 (428 mg, 3.1 mmol) and potassium iodide (64.3 mg, 0.38 mmol), then the mixture was heated at 60 C overnight under argon protection. The reaction mixture was cooled to rt and poured into water (10 mL), and extracted with EtOAc. The combined organic layers were washed with brine, and dried over Na2SO4. The organic solvents were removed under vacuum, and the residue was purified by silica gel column chromatography (0-100% ethyl acetate/hexanes) to give the title compound as a colorless oil (100 mg, 46.3%) MS: 278 [M+H]+;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58539-77-8, 3-(Chloromethyl)-2-methylpyridine hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19621; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem