Category: 58584-94-4

Related Products of 58584-94-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58584-94-4, name is 2,6-Dichloro-3-methylpyridine, molecular formula is C6H5Cl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(2d) 2,6-Dichloro-3-methyl-5-nitropyridine [Formula 21]; Anhydrous trifluoromethanesulfonic acid (21.9 ml, 129 mmol) was dropped into a mixture of tetramethyl ammonium nitrate (17.3 g, 127 mmol) and dichloromethane (60 ml) at 0C under nitrogen flow, and the reaction mixture was stirred for 1.5 hours while elevating to room temperature. After a 10: 1.5 mixture (13.7 g) of 2,6-dichloro-3-methylpyridine and 2,4-dichloro-5- methylpyridine in dichloromethane (20 ml) was added and stirred for 30 minutes at room temperature, the reaction mixture was stirred under reflux for 48 hours. The reaction mixture was poured into a saturated sodium bicarbonate solution, and extracted with dichloromethane (200 ml), and after washed with water, dried over magnesium sulfate. The residue obtained by evaporating the solvent was triturated with heptane, thereby yielding the title compound (6.55 g, 31.6 mmol) as a pale brown solid. ¹H NMR (400MHz, DMSO-d6)8 ppm; 2.42(3H, s), 8.70(1H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58584-94-4, 2,6-Dichloro-3-methylpyridine.

Reference:
Patent; EISAI CO., LTD.; WO2005/103049; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58584-94-4, name is 2,6-Dichloro-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

Step 2. To 3-(tributylstannyl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine (1.1 g, 2.31 mmol) was added the obtained product, dioxane (6 mL), QPhos (49 mg, 0.07 mmol) and Pd2dba3 (21 mg, 0.023 mmol). The mixture was heated at 110 C for one hour, then at 90 C for 15 hours. The product was concentrated and purified by chromatography on silica gel (gradient ethyl acetate :hexane 1:10 to 1:1) to provide a mixture of crude isomers: 3-(6- chloro-5-methylpyridin-2-yl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine as a pink solid (58 mg, 8 ) and 3-(6-chloro-3-methylpyridin-2-yl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine (more polar) (130 mg).

With the rapid development of chemical substances, we look forward to future research findings about 58584-94-4.

Reference:
Patent; PTC THERAPEUTICS, INC.; BAIAZITOV, Ramil; CHOI, Soongyu; DU, Wu; HWANG, Seongwoo; LEE, Chang-Sun; LIU, Ronggang; MOON, Young-Choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald; WO2015/76800; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem