Category: 586-95-8

Related Products of 586-95-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 586-95-8, name is 4-Pyridinemethanol, molecular formula is C6H7NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-pyridylcarbinol (15 g, 137.4 mmol) in DCM (200 ml) was added thionyl chloride (43.6 ml) and the resulting reaction mixture was stirred at room temperature for 4 h. The mixture was cooled to room temperature and the solvent was evaporated in vacuo. The residue was diluted with DCM and washed with a saturated solution Of NaHCO3. The combined organic layers were dried over Na2SO4 and con- centrated in vacuo to yield intermediate compound 29 (17.18 g, 99 %).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 586-95-8, 4-Pyridinemethanol.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; ADDEX PHARMACEUTICALS S.A.; WO2007/104783; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 586-95-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.586-95-8, name is 4-Pyridinemethanol, molecular formula is C6H7NO, molecular weight is 109.13, as common compound, the synthetic route is as follows.

(l-Benzyl-l,2,3,6-tetrahydropyridin-4-yl)methanol. 4-Hydroxymethyl- pyridine (20 g, 183 mmol, 1.0 eq) was dissolved in DMF (80 mL) andbenzylbromide (24.2 mL; 202 mmol) was added and the solution was stirred at 100 C for 2 hours. The solution was allowed to cool to RT and diluted with EtOH (300 mL) and treated portionwise with NaBH4 (8.7 g; 230 mmol) and stirred at reflux for 3 hours. The solution was allowed to cool to RT and concentrated largely. The residue was taken up in EtOAc and water and the organic phase was dried (Na2S04), filtered and concentrated to give 35 g crude oil. The material was purified with a short plug (10 cm) of silica eluting with EtOAc to give the product (23.9 g; 64%) which was isolated as an oil. NMR (300 MHz, CDC13) delta ppm 7.39-7.2 (m, 5H), 5.69-5.63 (m, 1H), 4.03 (s, 2H), 3.58 (s, 2H), 3.0 (m, 2H), 2.6 (t, J= 6 Hz, 2H), 2.21-2.11 (m, 2H).

Statistics shows that 586-95-8 is playing an increasingly important role. we look forward to future research findings about 4-Pyridinemethanol.

Reference:
Patent; ABBOTT HEALTHCARE PRODUCTS B.V.; STOIT, Axel; IWEMA BAKKER, Wouter, I.; COOLEN, Hein K.A.C.; VAN DONGEN, Maria J.P.; LEFLEMME, Nicolas J.-L.D.; WO2012/4378; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 586-95-8 ,Some common heterocyclic compound, 586-95-8, molecular formula is C6H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(IV) 4-Chloromethylpyridine hydrochloride (19) STR16 4-Hydroxymethylpyridine (18) 54.4 g (0.50 mol) was dissolved in acetonitrile 202 ml. The solution was added dropwise to the mixture of thionyl chloride 65.3 g (0.55 mol) and acetonitrile 109 ml under 50 C. The mixture was stirred at the same temperature for 1 hour, then cooled to room temperature to yield the slurry (quantitative) of the objective (19). 1 H-NMR (DMSO-TMS) delta ppm: 5.09 (s, 2H), 8.09 (d, J=6.6 Hz, 2H), 8.94 (d, J=6.6 Hz, 2H),

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,586-95-8, its application will become more common.

Reference:
Patent; Shionogi & Co., Ltd.; US6057448; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 586-95-8, name is 4-Pyridinemethanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H7NO

(i) Reaction of 4-(hydroxymethyl)pyridine with thionyl chloride gives 4-(chloromethyl)pyridine which is reacted with

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 586-95-8, 4-Pyridinemethanol.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4385058; (1983); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In an article, author is Mala, Ramanjaneyulu, once mentioned the application of 586-95-8, Name is 4-Pyridinemethanol, molecular formula is C6H7NO, molecular weight is 109.13, MDL number is MFCD00006442, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 586-95-8.

An Imidazo[1,2-a]pyridine Derivative That Enables Selective and Sequential Sensing of Cu2(+) and CN- Ions in Aqueous and Biological Samples

We report a triazole appended imidazopyridine based chemosensor (probe 1) for sequential detection of Cu2+ and CN- ions using fluorometry. Probe 1 is fluorescent in aqueous acetonitrile (H2O-CH3CN, 1:1, v/v) when common metal ions are present, but the fluorescence is quenched when Cu2+ is present. The binding mechanism, quantitative determination and the mode of interaction of Cu2+ with probe 1 are explained using fluorescence spectroscopy, electrospray ionization mass spectrometry and Density Functional Theory (DFT) calculations. The observed detection limit for Cu2+ is found to be (18.17 x 10(-6) M) and it is comparable with those reported for other Cu2+ chemosensors. Further, the 1-Cu2+ complex formation is found to be reversible, and this property has been successfully exploited for the quantitative determination of CN- ions in aqueous acetonitrile. Addition of CN- leads to a complete recovery of fluorescence from 1-Cu2+ complex, permitting the real time detection with the lower limit of detection of CN being 33.57 x 10(-6) M. The observed experimental results are supported by DFT calculations. A possible application of 1-Cu2+ in fluorescence imaging of Rhizoctonia solani mycelia cells, contaminated with CN ions, is also represented.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 586-95-8, Recommanded Product: 586-95-8.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is an experimental science, Category: pyridine-derivatives, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 586-95-8, Name is 4-Pyridinemethanol, molecular formula is C6H7NO, belongs to pyridine-derivatives compound. In a document, author is Mahernia, Shabnam.

The possible effect of microRNA-155 (miR-155) and BACE1 inhibitors in the memory of patients with down syndrome and Alzheimer’s disease: Design, synthesis, virtual screening, molecular modeling and biological evaluations

MiR-155 plays main roles in several physiological and pathological mechanisms, such as Down syndrome (DS), immunity and inflammation and potential anti-AD therapeutic target. The miR-155 is one of the overexpressed miRNAs in DS patients that contribute directly and indirectly to the onset or progression of the DS. Since the miR-155 can simultaneously reduce the translation of several genes at post-transcriptional levels, targeting the miR-155 might set the stage for the treatment of DS. One of the rational strategies in providing therapeutic interventions in this respect is to design and develop novel small molecules inhibiting the miR-155 function or biogenesis or maturation. In the present study, we aim to introduce small molecule compounds with the potential to inhibit the generation of the selectively miR-155 processing by employing computational drug design approaches, as well as in vitro studies. We designed and synthesized a novel series of imidazo[1,2-a]pyridines derivatives as new nonpeptic candidates for the treatment of DS with AD. The designed compounds were investigated for their BACE1 and miR-155 binder inhibitory potential in vitro and in cell. In addition, we present a systematic computational approach that includes 3 D modeling, docking-based virtual screening, and molecular dynamics simulation to identify Small – molecule inhibitors of pre-miR-155 maturation. To confirm the inhibitory potential of compound 8k on miR-155 maturation, qRT- PCR was performed. All our results confirm that compound 8k, in addition to being a good inhibitor of BACE1, can also be a good inhibitor of miR-155. Communicated by Ramaswamy H. Sarma

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 586-95-8. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 586-95-8, Name is 4-Pyridinemethanol. In a document, author is Khalaj, M., introducing its new discovery. HPLC of Formula: C6H7NO.

Synthesis, Crystal Structure, and Antibacterial Activity of Di-mu-chlorido-bis({2-[(4-methoxyphenyl)-iminomethyl]pyridine-kappa N-2,N’] Mercury(II)

A coordination polymer [Hg(L)Cl-2](n) consisting of HgCl2 and Schiff base bidentate ligand (4-methoxyphenyl) pyridine-2yl methyleneamine (L) was prepared and structurally characterized. Coordination compound has been characterized by infrared spectroscopy, UV-visible spectroscopy, elemental analysis, and single-crystal X-ray diffraction. The compound crystallizes in the monoclinic sp. gr. P2(1)/c with a = 9.3053(17), b = 7.1125(13), c = 20.708(4) angstrom, and beta = 80.208(4)degrees. In the 1D network structure, the mercury(II) ion adopts a HgN2Cl3 distorted square pyramid geometry. In this complex, one chlorine atom acts as bridging ligand connecting two adjacent mercury(II) ions, while the L ligand is coordinated to mercury(II) ion in a cyclic-bidentate fashion forming a five-membered metallocyclic ring. Antibacterial activity of the complex, ligand, and metal salt was tested against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 586-95-8 help many people in the next few years. HPLC of Formula: C6H7NO.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 586-95-8, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 586-95-8, Name is 4-Pyridinemethanol, SMILES is OCC1=CC=NC=C1, belongs to pyridine-derivatives compound. In a article, author is Volkov, P. A., introduce new discover of the category.

Chemoselective Vinylation of the Quinine Hydroxy Group with the System Electron-Deficient Acetylene/Diphenylphosphine Oxide: an Alternative to (SNAr)-Ar-H Reaction

Three-component (SNAr)-Ar-H reaction of quinine, diphenylphosphine oxide, and furoylacetylene chemoselectively afforded the corresponding quinine vinyl ether and 2 : 1 adduct of diphenylphosphine oxide to the triple bond of furoylacetylene instead of the expected cross-coupling product at the pyridine ring.

Reference of 586-95-8, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 586-95-8 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 586-95-8, Name is 4-Pyridinemethanol, molecular formula is C6H7NO, belongs to pyridine-derivatives compound. In a document, author is Bera, Pradip, introduce the new discover, Formula: C6H7NO.

Synthesis, structure elucidation and dft study of a new thiazole-pyridine anchored nnn donor and it’s cobalt(II) complex: In-vitro antitumor activity against U937 cancer cells, dna binding property and molecular docking study

The reaction between 4-(2-bromoacetyl)benzonitrile and 2-benzoylpyridine thiosemicarbazone produces a tridentate NNN ligand, 4-(2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)thiazole-4-yl)benzonitrile (ppytbH). The ligand constructs an octahedral complex with composition [Co(ppytbH)(2)](ClO4)(2)center dot 3(H2O) (1) when reacted with cobalt(II) perchlorate salt in acetonitrile methanol (1:1) solution. The structures of ppytbH and 1 have been established by single X-ray crystallography, spectroscopic (H-1 NMR, IR, UVVisible and fluorescence), thermal and electrochemical methods. The chemical reactivity and HOMO- LUMO energy of the compounds have been calculated using Density Functional Theory (DFT). The compounds ppytbH and 1 exhibit potential anticancer activity against U937 human monocytic cells and IC50 values are found 12.76 +/- 0.75 and 12.83 +/- 1.37 mu M, respectively. The fluorescence and molecular docking study interpret the intercalative DNA binding mode with the titled molecules. (C) 2020 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 586-95-8. Formula: C6H7NO.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 586-95-8, Name is 4-Pyridinemethanol, molecular formula is C6H7NO. In an article, author is Park, Dongseong,once mentioned of 586-95-8, Computed Properties of C6H7NO.

Enantioselective C(sp(2))-H borylation of diarylmethylsilanes catalyzed by chiral pyridine-dihydroisoquinoline iridium complexes

Enantioselective C(sp(2))-H borylations of diarylmethylsilanes were catalyzed using iridium complexes with chiral pyridine-dihydroisoquinoline (PyDHIQ) ligands. High enantioselectivities (up to >99% ee) were observed for various substrates. A gram-scale synthesis was achieved using 1 mol% of the catalyst to afford a 91% yield of the desired chiral borylated organosilane product with >99% ee. (C) 2020 Elsevier Ltd. All rights reserved.

Interested yet? Keep reading other articles of 586-95-8, you can contact me at any time and look forward to more communication. Computed Properties of C6H7NO.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem